https://doi.org/10.4081/reumatismo.2014.788

Vitamin D and rheumatic diseases

Vol. 66 No. 2 (2014)
Submitted: 28 July 2014
Accepted: 28 July 2014
Published: 28 July 2014
Vitamin D, Rheumatic diseases.
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Authors

M. Rossini
maurizio.rossini@univr.it
Rheumatology Unit, University of Verona, Italy.
D. Gatti
Rheumatology Unit, University of Verona, Italy.
O. Viapiana
Rheumatology Unit, University of Verona, Italy.
C. Caimmi
Rheumatology Unit, University of Verona, Italy.
L. Idolazzi
Rheumatology Unit, University of Verona, Italy.
E. Fracassi
Rheumatology Unit, University of Verona, Italy.
S. Adami
Rheumatology Unit, University of Verona, Italy.
Vitamin D has some well-known effects on calcium, phosphate and bone metabolism, but it has recently shown to have many other effects, which may potentially be relevant to patients with extra-skeletal rheumatic diseases. Such effects may be justified by: 1) the presence of the vitamin D receptors also on extra-osseous cells, such as cartilage cells, sinoviocytes, muscle cells; 2) the proven role of vitamin D in the control of the transcription of genes involved in rheumatic diseases; 3) the evidence that vitamin D has multiple endocrine effects not only on calcium homeostasis; 4) the activation of vitamin D not only in the kidneys, but also in monocyte-macrophage and lymphocytic cell lines and in some epithelial cells with additional intracrine and paracrine effects. Vitamin D deficiency has been reported in numerous metabolic, degenerative, inflammatory and autoimmune rheumatic diseases. In some cases this association was also related to the risk of developing a rheumatic disease or the degree of disease activity. However there is no conclusive evidence of the efficacy of a preventive or therapeutic strategy based on vitamin D supplementation in extra-skeletal rheumatic diseases. This review aims to provide an overview of the latest evidence concerning the relationship between vitamin D and the most relevant rheumatic diseases.

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How to Cite

Rossini, M., Gatti, D., Viapiana, O., Caimmi, C., Idolazzi, L., Fracassi, E., & Adami, S. (2014). Vitamin D and rheumatic diseases. Reumatismo, 66(2), 153–170. https://doi.org/10.4081/reumatismo.2014.788

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