https://doi.org/10.4081/reumatismo.2013.97

Bradykinin and its role in osteoarthritis

Vol. 65 No. 3 (2013)
Submitted: 15 May 2013
Accepted: 11 July 2013
Published: 23 July 2013
Bradykinin B2 receptor antagonists, Bradykinin, Fasitibant, Icatibant, osteoarthritis.
Abstract Views: 3015
PDF: 1794
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

L. De Falco
Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Italy.
A. Fioravanti
fioravanti7@virgilio.it
Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Italy.
M. Galeazzi
Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Italy.
S. Tenti
Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Italy.
Osteoarthritis (OA), the most common joint disorder, is a disease involving all the articular structures. It presents both degenerative and inflammatory aspects. Recently, the important role of Bradykinin (BK), a phlogistic mediator, has been proposed in the pathophysiology of OA. In our review, we summarized the currently available information on the mechanisms of action of BK in OA by linking its B2 receptors. Then, we analyzed the data about the effects of BK in synoviocytes and chondrocytes cultures. Furthermore, we described the action of B2 receptor antagonists (Icatibant and Fasitibant), presenting them as new promising symptom-anddisease- modifying agents in the treatment of OA. However, more in vitro, animal model and clinical studies, are needed to better understand the mechanisms of action as well as the efficacy and tolerability of the B2 receptor antagonists in OA.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

De Falco, L., Fioravanti, A., Galeazzi, M., & Tenti, S. (2013). Bradykinin and its role in osteoarthritis. Reumatismo, 65(3), 97–104. https://doi.org/10.4081/reumatismo.2013.97

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Similar Articles

<< < 1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.