https://doi.org/10.4081/reumatismo.2013.720

Acute colchicine overdose: report of three cases

Vol. 65 No. 6 (2013)
Submitted: 23 September 2013
Accepted: 17 December 2013
Published: 17 March 2014
Colchicine, Acute toxicity, Fulminant aplasia, Disseminated intravascular coagulopathy, Outcome, Treatment, Acute respiratory distress syndrome.
Abstract Views: 3687
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Authors

A. Aghabiklooei
Department of Forensic Medicine, Iran University of Medical Sciences, Tehran; Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.
N. Zamani
Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.
H. Hassanian-Moghaddam
hassanian@sbmu.ac.ir
Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.
S. Nasouhi
Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.
M. Mashayekhian
Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.
Intentional acute toxicity by colchicine is not common but accompanies a high rate of complications and mortality. It is generally assumed to be an emergency in clinical toxicology. Rapid diagnosis and treatment can prevent death. The most common causes of death in this toxicity are acute cardiac failure, shock, and dysrhythmias with hematopoietic complications occurring in later stages. We report three cases of acute colchicine toxicity, two of which expired, with different presenting and ongoing signs and symptoms. We aimed to define the different possible clinical manifestations of the toxicity and review the probable treatments available for these patients.

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How to Cite

Aghabiklooei, A., Zamani, N., Hassanian-Moghaddam, H., Nasouhi, S., & Mashayekhian, M. (2014). Acute colchicine overdose: report of three cases. Reumatismo, 65(6), 307–311. https://doi.org/10.4081/reumatismo.2013.720

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