https://doi.org/10.4081/reumatismo.2013.55

Childhood versus adulthood-onset autoinflammatory disorders: myths and truths intertwined

Vol. 65 No. 2 (2013)
Submitted: 23 February 2013
Accepted: 31 May 2013
Published: 12 June 2013
Autoinflammatory disorders, Child, Adult, Interleukin-1β.
Abstract Views: 6152
PDF: 1021
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Authors

L. Cantarini
cantariniluca@hotmail.com
Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy.
A. Vitale
Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy.
O.M. Lucherini
Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy.
I. Muscari
Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy.
F. Magnotti
Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy.
G. Brizi
Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy.
B. Frediani
Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy.
G.D. Sebastiani
U.O.C. di Reumatologia, Azienda Ospedaliera San Camillo-Forlanini, Roma, Italy.
M. Galeazzi
Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy.
D. Rigante
Institute of Pediatrics, Università Cattolica Sacro Cuore, Roma, Italy.
Autoinflammatory disorders are characterized by spontaneous episodes of systemic inflammation deriving from inherited defects of the innate immune system. Childhood is usually the lifetime involved in most inherited autoinflammatory disorders, but a moderate number of patients may experience disease onset during adulthood. Herein we report our experience in the clinical and genetic approach to the diagnosis of autoinflammatory disorders in regard of the first 500 pediatric and adult patients evaluated during the period 2007-2012 in our Center, due to histories of periodically-recurring inflammatory attacks, giving emphasis to the differences observed according to patients’age and to the most relevant data differentiating child and adult-onset autoinflammatory disorders in the medical literature.

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How to Cite

Cantarini, L., Vitale, A., Lucherini, O., Muscari, I., Magnotti, F., Brizi, G., … Rigante, D. (2013). Childhood versus adulthood-onset autoinflammatory disorders: myths and truths intertwined. Reumatismo, 65(2), 55–62. https://doi.org/10.4081/reumatismo.2013.55

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