https://doi.org/10.4081/reumatismo.2013.253

Secondary hemophagocytic lymphohistiocytosis possibly induced by interferon beta-1a therapy.

Vol. 65 No. 5 (2013)
Submitted: 9 September 2013
Accepted: 7 November 2013
Published: 18 December 2013
Interferon, Hemophagocytosis, Macrophage activation syndrome, Hemophagocytic lymphohistiocytosis, Multiple sclerosis.
Abstract Views: 2880
PDF: 743
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

C. Cosso
claudio.cosso86@gmail.com
Clinica Reumatologica, Dipartimento di Medicina Interna, Università di Genova, Italy.
R. Cosso
Divisione di Medicina Generale, Ospedale A. Gallino, Genova, Italy.
M.A. Cimmino
Clinica Reumatologica, Dipartimento di Medicina Interna, Università di Genova, Italy.
A 57-year old woman with a history of multiple sclerosis, treated with interferon beta-1a in the last 5 months, was referred for hyperpyrexia (>40°C) that persisted for 15 days. At admission, there was elevation of transaminases, anemia (hemoglobin 8.9 g/dL), thrombocytopenia (platelet 135,000/mm3), and hypofibrinogenemia (fibrinogen 1.26 g/L). C-reactive protein was 10.7 mg/dL, lactate dehydrogenase 1270 U/L and ferritin 2380 ng/ mL, with hepatosplenomegaly and linfoadenomegaly. Hemophagocytic lymphohistiocytosis induced by direct stimulation of macrophages by interferon (IFN) was suspected. IFN was withdrawn as only measure and onemonth later signs and symptoms disappeared, with complete normalization of laboratory examinations.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

Cosso, C., Cosso, R., & Cimmino, M. (2013). Secondary hemophagocytic lymphohistiocytosis possibly induced by interferon beta-1a therapy. Reumatismo, 65(5), 253–255. https://doi.org/10.4081/reumatismo.2013.253

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Similar Articles

<< < 4 5 6 7 8 9 10 11 12 13 > >> 

You may also start an advanced similarity search for this article.