https://doi.org/10.4081/reumatismo.2012.7
MicroRNAs in autoimmune rheumatic diseases
Submitted: 18 October 2011
Accepted: 29 November 2011
Published: 16 March 2012
Accepted: 29 November 2011
Abstract Views: 822
PDF: 800
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The etiology of autoimmune diseases remains largely unknown. In recent years, besides genetic factors, several studies proposed that the epigenome may hold the key to a better understanding of autoimmunity initiation and perpetuation. More specifically epigenetic regulatory mechanisms comprise DNA methylation, a variety of histone modifications, and microRNA (miRNA) activity, all of which act upon gene and protein expression levels. In particular it is well known that epigenetic mechanisms are important for controlling the pattern of gene expression during development, the cell cycle, and the response to biological or environmental changes. In the present review a description of the most frequent epigenetic deregulations, in particular the role of miRNA, in rheumatic autoimmune disorders will be analyzed.
Supporting Agencies
FIRA (Fondazione Italiana per la Ricerca sull'Artrite)How to Cite
Galeazzi, M., Balistreri, E., Giannitti, C., & Sebastiani, G. (2012). MicroRNAs in autoimmune rheumatic diseases. Reumatismo, 64(1), 7–17. https://doi.org/10.4081/reumatismo.2012.7
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