https://doi.org/10.4081/reumatismo.2012.7
MicroRNAs in autoimmune rheumatic diseases
Accepted: 29 November 2011
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The etiology of autoimmune diseases remains largely unknown. In recent years, besides genetic factors, several studies proposed that the epigenome may hold the key to a better understanding of autoimmunity initiation and perpetuation. More specifically epigenetic regulatory mechanisms comprise DNA methylation, a variety of histone modifications, and microRNA (miRNA) activity, all of which act upon gene and protein expression levels. In particular it is well known that epigenetic mechanisms are important for controlling the pattern of gene expression during development, the cell cycle, and the response to biological or environmental changes. In the present review a description of the most frequent epigenetic deregulations, in particular the role of miRNA, in rheumatic autoimmune disorders will be analyzed.
Supporting Agencies
FIRA (Fondazione Italiana per la Ricerca sull'Artrite)How to Cite
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- C. Cervini, G. Leardini, A. Mathieu, L. Punzi, R. Scarpa, Psoriatic arthritis: epidemiological and clinical aspects in a cohort of 1.306 italian patients , Reumatismo: Vol. 57 No. 4 (2005)
- R. Scrivo, A. Spadaro, V. Riccieri, M. Bombardieri, M. Di Franco, D. Celestino, G. Valesini, Soluble P-selectin levels in synovial fluid and serum from patients with psoriatic arthritis , Reumatismo: Vol. 57 No. 4 (2005)
- D. Malesci, G. La Montagna, G. Valentini, The arthropathy of systemic sclerosis , Reumatismo: Vol. 57 No. 4 (2005)
- V.F. Azevedo, C.F. Pietrovski, M. de Almeida Santos Jr, Acute toxoplasmosis infection in a patient with ankylosing spondylitis treated with adalimumab: a case report , Reumatismo: Vol. 62 No. 4 (2010)
- M. Fabris, L. Quartuccio, S. Lombardi, M. Benucci, M. Manfredi, M. Saracco, F. Atzeni, P. Morassi, M.A. Cimmino, E. Pontarini, C. Fabro, R. Pellerito, P. Sarzi-Puttini, M. Cutolo, A. Carletto, L.M. Bambara, F. Fischetti, F. Curcio, E. Tonutti, S. De VIta, Study on the possible role of the -174G>C IL-6 promoter polymorphism in predicting response to rituximab in rheumatoid arthritis , Reumatismo: Vol. 62 No. 4 (2010)
- M. Cutolo, C. Pizzorni, M. Meroni, G. Zampogna, C. Ferrone, E. Alessandri, F. Ravera, A. Sulli, The role of nailfold videocapillaroscopy in Raynaud’s phenomenon monitoring and early diagnosis of systemic sclerosis , Reumatismo: Vol. 62 No. 4 (2010)
- P. Ostuni, M.E.C. Battista, A. Furlan, Efficacy of Carbopol 974P (Siccafluid) in the treatment of severe to moderate keratoconjunctivitis sicca (KCS) in patients with primary Sjögren’s syndrome (SS) not responding to standard treatment with artificial tears , Reumatismo: Vol. 57 No. 2 (2005)
- R. Gualtierotti, L. Scalone, F. Ingegnoli, P. Cortesi, C. Lubatti, S. Zeni, P.L. Meroni, Health related quality of life assessment in patients with systemic sclerosis , Reumatismo: Vol. 62 No. 3 (2010)
- M. Benucci, F. Li Gobbi, A. Del Rosso, M. Manfredi, Systemic lupus erythematosus: the first italian prevalence study , Reumatismo: Vol. 57 No. 2 (2005)
- F. Schiavon, C. Circhetta, L. Dani, The diabetic hand , Reumatismo: Vol. 56 No. 3 (2004)
<< < 43 44 45 46 47 48 49 50 51 52 > >>
You may also start an advanced similarity search for this article.
