https://doi.org/10.4081/reumatismo.2011.185

A short history of anti-rheumatic therapy - VII. Biological agents

Vol. 63 No. 3 (2011)
Submitted: 9 November 2011
Accepted: 9 November 2011
Published: 9 November 2011
History of rheumatology, biological agents, monoclonal antibodies, cytokines
Abstract Views: 1286
PDF: 1190
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

G. Pasero
Università di Pisa, Italy.
P. Marson
piero.marson@sanita.padova.it
Unità di Aferesi Terapeutica, U.O.C. Immunotrasfusionale, Azienda Ospedale Università di Padova, Italy.
B. Gatto
Dipartimento di Scienze Farmaceutiche, Università di Padova, Italy.
The introduction of biological agents has been a major turning-point in the treatment of rheumatic diseases, particularly in rheumatoid arthritis. This review describes the principle milestones that have led, through the knowledge of the structure and functions of nucleic acids, to the development of production techniques of the three major families of biological agents: proteins, monoclonal antibodies and fusion proteins. A brief history has also been traced of the cytokines most involved in the pathogenesis of inflammatory rheumatic diseases (IL-1 and TNF) and the steps which have led to the use of the main biological drugs in rheumatology: anakinra, infliximab, adalimumab, etanercept and rituximab.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

Pasero, G., Marson, P., & Gatto, B. (2011). A short history of anti-rheumatic therapy - VII. Biological agents. Reumatismo, 63(3), 185–194. https://doi.org/10.4081/reumatismo.2011.185

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Similar Articles

<< < 51 52 53 54 55 56 57 58 59 60 > >> 

You may also start an advanced similarity search for this article.