https://doi.org/10.4081/reumatismo.2011.185

A short history of anti-rheumatic therapy - VII. Biological agents

Vol. 63 No. 3 (2011)
Submitted: 9 November 2011
Accepted: 9 November 2011
Published: 9 November 2011
History of rheumatology, biological agents, monoclonal antibodies, cytokines
Abstract Views: 1286
PDF: 1190
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Authors

G. Pasero
Università di Pisa, Italy.
P. Marson
piero.marson@sanita.padova.it
Unità di Aferesi Terapeutica, U.O.C. Immunotrasfusionale, Azienda Ospedale Università di Padova, Italy.
B. Gatto
Dipartimento di Scienze Farmaceutiche, Università di Padova, Italy.
The introduction of biological agents has been a major turning-point in the treatment of rheumatic diseases, particularly in rheumatoid arthritis. This review describes the principle milestones that have led, through the knowledge of the structure and functions of nucleic acids, to the development of production techniques of the three major families of biological agents: proteins, monoclonal antibodies and fusion proteins. A brief history has also been traced of the cytokines most involved in the pathogenesis of inflammatory rheumatic diseases (IL-1 and TNF) and the steps which have led to the use of the main biological drugs in rheumatology: anakinra, infliximab, adalimumab, etanercept and rituximab.

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How to Cite

Pasero, G., Marson, P., & Gatto, B. (2011). A short history of anti-rheumatic therapy - VII. Biological agents. Reumatismo, 63(3), 185–194. https://doi.org/10.4081/reumatismo.2011.185

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