https://doi.org/10.4081/reumatismo.2004.247

Peripheral nervous system in limited systemic sclerosis

Vol. 56 No. 4 (2004)
Abstract Views: 840
PDF: 969
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

A. Del Rosso
office@pagepress.org
L. Ibba Manneschi
A. Tani
D. Nosi
A. Franca Milia
S. Generini
S. Guiducci
D. Melchiorre
A. Pignone
M. Matucci Cerinic
Objectives. PNS is involved in Systemic Sclerosis (SSc) since the earliest phases. Our aim is to perform an ultrastructural study on skin PNS fibers in SSc. Methods. Skin biopsies were taken from forearms of 8 patients affected by limited SSc (lSSc) and 3 controls and processed for transmission electron microscopy (TEM). The semithin sections (2 mm) were observed at light microscope and optical fields were chosen for ultrathin sections (1 mm) preparation and TEM examination. Results. In lSSc skin, in the semithin sections, damaged areas are close to apparently spared areas. At TEM, in early lSSc patients, signs of inflammation and damaged microvessels are visible in derma. PNS fibers are no damaged. In advanced lSSc, fibrosis prevails on inflammation, and slight ultrastructural alterations of PNS fibers are evident in papillar derma. Conclusions. PNS lesions are different in severity in lSSc according to the disease duration, resulting more severe in advanced than in early phase.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

Del Rosso, A., Ibba Manneschi, L., Tani, A., Nosi, D., Franca Milia, A., Generini, S., … Matucci Cerinic, M. (2004). Peripheral nervous system in limited systemic sclerosis. Reumatismo, 56(4), 247–252. https://doi.org/10.4081/reumatismo.2004.247

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.