https://doi.org/10.4081/reumatismo.2016.897

Risk of cytomegalovirus reactivation in patients with immune-mediated inflammatory diseases undergoing biologic treatment: a real matter?

Vol. 68 No. 3 (2016)
Submitted: 7 July 2016
Accepted: 5 October 2016
Published: 16 December 2016
Cytomegalovirus, screening, biological agents, inflammatory diseases.
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Authors

J. Mencarini
Infectious Diseases Unit, University of Florence, Italy.
M. Spinicci
Infectious Diseases Unit, University of Florence, Italy.
F. Bartalesi
bartalesif@aou-careggi.toscana.it
Infectious and Tropical Diseases Division, Careggi Hospital, Florence, Italy.
The use of biological agents has grown exponentially in immune-mediated inflammatory diseases (IMID), often achieving a good control of disease progression and improving patients’ quality of life. However, their use resulted in an increased risk of adverse events, including reactivation of chronic/latent infectious diseases. As for the risk of Cytomegalovirus (CMV) reactivation, very few data are available. We reviewed the literature reporting cases of CMV infection in IMID patients during biological therapy. Although the risk of CMV reactivation cannot be excluded, we concluded that there is no evidence to warrant CMV screening before starting a biological agent.

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How to Cite

Mencarini, J., Spinicci, M., & Bartalesi, F. (2016). Risk of cytomegalovirus reactivation in patients with immune-mediated inflammatory diseases undergoing biologic treatment: a real matter?. Reumatismo, 68(3), 144–147. https://doi.org/10.4081/reumatismo.2016.897

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