https://doi.org/10.4081/reumatismo.2016.885

Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study

Vol. 68 No. 2 (2016)
Submitted: 30 March 2016
Accepted: 16 July 2016
Published: 9 September 2016
Axial spondyloarthritis, early onset spondyloarthritis, disease activity, clinimetric indices spine, sacroiliac joints.
Abstract Views: 2486
PDF: 1655
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

M. Lorenzin
Rheumatology Unit, Department of Medicine, University of Padova, Italy.
A. Ortolan
Rheumatology Unit, Department of Medicine, University of Padova, Italy.
P. Frallonardo
Rheumatology Unit, Department of Medicine, University of Padova, Italy.
S. Vio
Radiology Unit, University of Padova, Italy.
C. Lacognata
Radiology Unit, University of Padova, Italy.
F. Oliviero
Rheumatology Unit, Department of Medicine, University of Padova, Italy.
L. Punzi
Rheumatology Unit, Department of Medicine, University of Padova, Italy.
R. Ramonda
roberta.ramonda@unipd.it
Rheumatology Unit, Department of Medicine, University of Padova, Italy.
Our aim was to determine the prevalence of spine and sacroiliac joint (SIJ) lesions on magnetic resonance imaging (MRI) in patients with early axial spondyloarthritis (axSpA) and their correlation with disease activity indices. Sixty patients with low back pain (LBP) (≥3 months, ≤2 years, onset ≤45 years), attending the SpA-clinic of the Unità Operativa Complessa Reumatologia of Padova [SpondyloArthritis-Caught-Early (SPACE) study], were studied following a protocol including physical examination, questionnaires, laboratory tests, X-rays and spine and SIJ MRI. Positive spine and SIJ MRI and X-rays images were scored independently by 2 readers using the SPARCC method, modified Stoke ankylosing spondylitis spine score and New York criteria. The axial pain and localization of MRI-lesions were referred to 4 sites: cervical/thoracic/lumbar spine and SIJ. All patients were classified into three groups: patients with signs of radiographic sacroiliitis (r-axSpA), patients without signs of r-axSpA but with signs of sacroiliitis on MRI (nr-axSpA MRI SIJ+), patients without signs of sacroiliitis on MRI and X-rays (nr-axSpA MRI SIJ-). The median age at LBP onset was 29.05±8.38 years; 51.6% of patients showed bone marrow edema (BME) in spine-MRI and 56.7% of patients in SIJ-MRI. Signs of enthesitis were found in 55% of patients in the thoracic district. Of the 55% of patients with BME on spine-MRI, 15% presented presented a negative SIJMRI. There was a significant difference between these cohorts with regard to the prevalence of radiographic sacroiliitis, active sacroiliitis on MRI and SPARCC SIJ score. The site of pain correlated statistically with BME lesions in thoracic and buttock districts. Since positive spine-MRI images were observed in absence of sacroiliitis, we can hypothesize that this finding could have a diagnostic significance in axSpA suspected axSpA.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
M. Lorenzin, Rheumatology Unit, Department of Medicine, University of Padova
Rheumatologist, MD
A. Ortolan, Rheumatology Unit, Department of Medicine, University of Padova
Rheumatologist, MD
P. Frallonardo, Rheumatology Unit, Department of Medicine, University of Padova
Rheumatologist, MD
S. Vio, Radiology Unit, University of Padova
Radiologist, MD
C. Lacognata, Radiology Unit, University of Padova
Radiologist,MD PhD
F. Oliviero, Rheumatology Unit, Department of Medicine, University of Padova
Researcher PhD
L. Punzi, Rheumatology Unit, Department of Medicine, University of Padova
Rheumatologist, MD PhD
R. Ramonda, Rheumatology Unit, Department of Medicine, University of Padova
Rheumatologist, MD PhD

How to Cite

Lorenzin, M., Ortolan, A., Frallonardo, P., Vio, S., Lacognata, C., Oliviero, F., … Ramonda, R. (2016). Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study. Reumatismo, 68(2), 72–82. https://doi.org/10.4081/reumatismo.2016.885

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Similar Articles

<< < 50 51 52 53 54 55 56 57 58 59 > >> 

You may also start an advanced similarity search for this article.