https://doi.org/10.4081/reumatismo.2016.872

Real-world experiences of folic acid supplementation (5 versus 30 mg/week) with methotrexate in rheumatoid arthritis patients: a comparison study

Vol. 68 No. 2 (2016)
Submitted: 20 February 2016
Accepted: 1 August 2016
Published: 9 September 2016
Folic acid, methotrexate, rheumatoid arthritis, disease activity score 28, treatment regimes.
Abstract Views: 2161
PDF: 1313
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

K.T. Koh
Department of Medicine, Miri Hospital, Sarawak, Malaysia.
C.L. Teh
tehchenglay@yahoo.com
Department of Medicine, Unit of Rheumatology, Sarawak General Hospital, Sarawak, Malaysia.
C.K. Cheah
Department of Medicine, Tuanku Ja’afar Hospital, Seremban, NS, Malaysia.
G.R. Ling
Department of Medicine, Unit of Rheumatology, Sarawak General Hospital, Sarawak, Malaysia.
M.C. Yong
Department of Medicine, Unit of Rheumatology, Sarawak General Hospital, Sarawak, Malaysia.
H.C. Hong
Department of Medicine, Tuanku Ja’afar Hospital, Seremban, NS, Malaysia.
S.C. Gun
Department of Medicine, Tuanku Ja’afar Hospital, Seremban, NS, Malaysia.
The objective of this study was to compare the tolerability of methotrexate in two different regimes of folic acid (FA) supplementation in rheumatoid arthritis (RA). We performed a multicenter, cross-sectional observational cohort study on 240 RA patients with 120 patients each in 5 mg of FA weekly and 30 mg of FA weekly supplementation. There were no significant differences for side effects (14.2 versus 22.5%, P=0.523) and discontinuation of methotrexate (3.6 versus 13.3%, P=0.085). RA patients given 5 mg of FA weekly supplementation had a lower disease activity score 28 compared to 30 mg of FA weekly supplementation [3.44 (1.10) versus 3.85 (1.40), P=0.014]. FA supplementation of 5 mg per week and 30 mg per week was associated with similar tolerability of methotrexate in RA patients.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

Koh, K., Teh, C., Cheah, C., Ling, G., Yong, M., Hong, H., & Gun, S. (2016). Real-world experiences of folic acid supplementation (5 versus 30 mg/week) with methotrexate in rheumatoid arthritis patients: a comparison study. Reumatismo, 68(2), 90–96. https://doi.org/10.4081/reumatismo.2016.872

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.