https://doi.org/10.4081/reumatismo.2015.851

The signal transducer and activator of transcription factors lodge in immunopathogenesis of rheumatoid arthritis

Vol. 67 No. 4 (2015)
Submitted: 22 November 2015
Accepted: 5 April 2016
Published: 23 May 2016
Immunopathogenes, rheumatoid arthritis, STAT proteins.
Abstract Views: 2388
PDF: 1056
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

F. Zare
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
M. Dehghan-Manshadi
Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd; Department of Immunology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of.
A. Mirshafiey
mirshafiey@tums.ac.ir
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
Rheumatoid arthritisis (RA) is a chronic autoimmune disorder that affects ~1-2% of the world’s population and damages synovial joints. RA is characterized by inflammation, autoantibody production, cartilage and bone destruction and synovial hyperplasia. Inflammation induces systemic and articular synthesis of pro-inflammatory cytokines, such as tumor necrosis factor alpha and interleukin-6 that play essential roles in joint and other organ damage in this disease. Considering the role of signal transducer and activator of transcription factors (STATs) in signaling of these cytokines, these proteins may be involved in the pathogenesis of RA. The expression and activity of STATs can contribute to the onset, progression and severity of RA. All STAT family members (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6) have been associated with autoimmune diseases, as highlighted in several studies. In this review we aim to describe the immunobiology of STATs and its family members and the role of these proteins in the immunopathogenesis of RA.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

Zare, F., Dehghan-Manshadi, M., & Mirshafiey, A. (2016). The signal transducer and activator of transcription factors lodge in immunopathogenesis of rheumatoid arthritis. Reumatismo, 67(4), 127–137. https://doi.org/10.4081/reumatismo.2015.851

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Similar Articles

<< < 1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.