After what time interval are we justified to diagnose immune checkpoint inhibitor-mediated polymyalgia rheumatica?

Published: 3 March 2025
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Dear Editor,
the number of cases of cancer patients diagnosed as having immune checkpoint inhibitor-mediated polymyalgia rheumatica has been steadily rising in published reports. However, the lack of a validated scale or algorithm is still a relevant methodological limit in diagnosing this nosologic entity...

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Citations

Hysa E, Casabella A, Gotelli E, Campitiello R, Schenone C, Genova C, et al. Polymyalgia rheumatica and giant cell arteritis induced by immune checkpoint inhibitors: a systematic literature review highlighting differences from the idiopathic forms. Autoimmun Rev 2024; 23: 103589. DOI: https://doi.org/10.1016/j.autrev.2024.103589
Kostine M, Finckh A, Bingham CO, Visser K, Leipe J, SchulzeKoops H, et al. EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors. Ann Rheum Dis 2020; 80: 36-48. DOI: https://doi.org/10.1136/annrheumdis-2020-217139
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reaction. Clin Pharmacol Ther 1981; 30: 239-45. DOI: https://doi.org/10.1038/clpt.1981.154
Manzo C, Natale M, Isetta M, Castagna A. Comment on: immune checkpoint inhibitor-mediated polymyalgia rheumatica versus primary polymyalgia rheumatica: comparison of disease characteristics and treatment requirement. Rheumatology 2025; 64: 900-1. DOI: https://doi.org/10.1093/rheumatology/keae259
Manzo C, Isetta M. Back to the future: identification and classification of polymyalgia rheumatica and polymyalgia rheumatica-like syndromes following cancer immunotherapy with checkpoint inhibitors. Reumatologia 2021; 59: 62-3. DOI: https://doi.org/10.5114/reum.2021.102600

How to Cite

Manzo, C., & Isetta, M. (2025). After what time interval are we justified to diagnose immune checkpoint inhibitor-mediated polymyalgia rheumatica?. Reumatismo. https://doi.org/10.4081/reumatismo.2025.1823

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