https://doi.org/10.4081/reumatismo.2024.1796
Baricitinib in polymyalgia rheumatica and giant cell arteritis: report of six cases
Submitted: 25 August 2024
Accepted: 13 October 2024
Published: 28 October 2024
Accepted: 13 October 2024
Abstract Views: 1016
PDF: 80
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The objective of this case series is to describe the efficacy and safety of baricitinib (BARI) in a group of patients with polymyalgia rheumatica (PMR) and/or giant cell arteritis (GCA). These patients were treated with BARI due to either a refractory disease course or the unavailability of tocilizumab because of the pandemic. A total of six patients (five females and one male, median age 64 years, range 50-83) were treated with BARI. Two of them had isolated PMR, two had PMR with associated large vessel (LV)-GCA, one had LV-GCA presenting as fever of unknown origin, and one had cranial-GCA. All patients reported improvement with BARI. At the time of starting BARI, patients were taking a median prednisone dose of 8.75 mg/day (range 0-25), and the four patients with PMR had a median PMR-activity score of 23.3 (indicating high disease activity), which decreased to 1.58 after 6 months of treatment with BARI. Two of them could stop glucocorticoids (GC) and continue BARI monotherapy. One patient suffered from pneumonia, and BARI was therefore stopped. No other adverse events attributable to BARI were detected. Our case series supports previous reports suggesting the efficacy of Janus kinase inhibitors as a GC-sparing strategy in PMR and GCA.
Camellino D, Matteson EL, Buttgereit F, Dejaco C. Monitoring and long-term management of giant cell arteritis and polymyalgia rheumatica. Nat Rev Rheumatol 2020; 16: 481-95.
Dejaco C, Singh YP, Perel P, Hutchings A, Camellino D, Mackie S, et al. 2015 recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Ann Rheum Dis 2015; 74: 1799-807.
Hellmich B, Agueda A, Monti S, Buttgereit F, De Boysson H, Brouwer E, et al. 2018 Update of the EULAR recommendations for the management of large vessel vasculitis. Ann Rheum Dis 2020; 79: 19-30.
Stone JH, Spotswood H, Unizony SH, Aringer M, Blockmans D, Brouwer E, et al. New-onset versus relapsing giant cell arteritis treated with tocilizumab: 3-year results from a randomized controlled trial and extension. Rheumatology 2022; 61: 2915-22.
Fragoulis GE, McInnes IB, Siebert S. JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis. Rheumatology 2019; 58: i43-54.
Rathore U, Thakare DR, Patro P, Agarwal V, Sharma A, Misra DP. A systematic review of clinical and preclinical evidences for Janus kinase inhibitors in large vessel vasculitis. Clin Rheumatol 2022; 41: 33-44.
Loricera J, Tofade T, Prieto-Peña D, Romero-Yuste S, de Miguel E, Riveros-Frutos A, et al. Effectiveness of janus kinase inhibitors in relapsing giant cell arteritis in real-world clinical practice and review of the literature. Arthritis Res Ther 2024; 26: 116.
Devauchelle-Pensec V, Saraux L, Berthelot JM, De Bandt M, Cornec D, Guellec D, et al. Assessing polymyalgia rheumatica activity when C-reactive protein is unavailable or uninterpretable. Rheumatology 2018; 57: 666-70.
Koster MJ, Crowson CS, Giblon RE, Jaquith JM, Duarte-García A, Matteson EL, et al. Baricitinib for relapsing giant cell arteritis: a prospective open-label 52-week pilot study. Ann Rheum Dis 2022; 81: 861-7.
Blockmans D, Penn SK, Setty A, Schmidt W, Rubbert-Roth A, Hauge EM, et al. LBA0001 efficacy and safety of upadacitinib in patients with giant cell arteritis (select-GCA): a double-blind, randomized controlled phase 3 trial. Ann Rheum Dis 2024; 83: 232-3.
Ma X, Yang F, Wu J, Xu B, Jiang M, Sun Y, et al. Efficacy and safety of tofacitinib in patients with polymyalgia rheumatica (EAST PMR): an open-label randomized controlled trial. PLoS Med 2023; 20: e1004249.
Terrades-Garcia N, Cid MC. Pathogenesis of giant-cell arteritis: how targeted therapies are influencing our understanding of the mechanisms involved. Rheumatology 2018; 57: ii51-62.
Camellino D, Giusti A, Girasole G, Bianchi G, Dejaco C. Pathogenesis, Diagnosis and Management of Polymyalgia Rheumatica. Drugs Aging 2019; 36: 1015-26.
Paroli M, Becciolini A, Lo Gullo A, Parisi S, Bravi E, Andracco R, et al. Influence of safety warnings on the prescribing attitude of JAK inhibitors for rheumatoid arthritis in Italy. J Clin Med 2024; 13: 3929.
Spinelli FR, Conti F, Caporali R, Iannone F, Cacciapaglia F, Steering Committee of the Italian Society of Rheumatology. Janus kinase inhibitors: between prescription authorization and reimbursability. Reumatismo 2023; 75: 1627.
How to Cite
Camellino, D., Dejaco, C., Martini, F., Cosso, R., & Bianchi, G. (2024). Baricitinib in polymyalgia rheumatica and giant cell arteritis: report of six cases. Reumatismo, 77(1). https://doi.org/10.4081/reumatismo.2024.1796
Copyright (c) 2024 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- M. Aouatef, B. Asma, H. Hajer, A. Charfeddine, B. Lamia, K. Taoufik, Work-related carpal tunnel syndrome treatment: a cross-sectional study among 106 patients , Reumatismo: Vol. 69 No. 2 (2017)
- M. Tasso, N. Bertolini, E. Mostacciuolo, S. Passavanti, J.M.E. Luppino, A. Del Puente, R. Peluso, F. Santelli, R. Scarpa, L. Costa, F. Caso, Effectiveness and safety profile of tofacitinib and baricitinib in rheumatoid arthritis patients: results from a 24-month real-life prospective study in Southern-Italy , Reumatismo: Vol. 74 No. 3 (2022)
- C. Pizzorni, A. Sulli, C. Craviotto, M. Tuccio, B. Seriolo, M. Cutolo, Diagnostic perspectives in the reumathological vasculitis: the role of the videocapillaroscopic analysis , Reumatismo: Vol. 54 No. 2 (2002)
- G.D. Sebastiani, Antineutrophil cytoplasmic antibodies , Reumatismo: Vol. 61 No. 1 (2009)
- M.T. Riccardi, A. Chialà, F. Iannone, V. Grattagliano, M. Covelli, G. Lapadula, Treatment of digital ulcers in systemtic sclerosis with endothelin-1 receptor antagonist (bosentan) , Reumatismo: Vol. 59 No. 2 (2007)
- S. Migliaresi, G. Di Iorio, A. Ammendola, L. Ambrosone, G. Sanges, G. Ugolini, S. Sampaolo, F. Bravaccio, G. Tirri, Peripheral nervous system involvement in HCV-related mixed cryoglobulinemia , Reumatismo: Vol. 53 No. 1 (2001)
- N. Ughi, G.D. Sebastiani, R. Gerli, C. Salvarani, S. Parisi, A. Ariani, I. Prevete, M. Manara, F. Rumi, C.A. Scirè, A. Bortoluzzi, Reply to the Letter to the Editor: The Italian Society of Rheumatology clinical practice guidelines for the management of polymyalgia rheumatica , Reumatismo: Vol. 72 No. 2 (2020)
- F.M. Perrotta, S. Scriffignano, M. Fatica, M. Specchia, E. Lubrano, Case report of polymyalgia rheumatica in a male patient with three different neoplasms treated with pembrolizumab , Reumatismo: Vol. 72 No. 3 (2020)
- C. Manzo, Clinical practice guidelines for patients with polymyalgia rheumatica: the need for an active involvement of all stakeholder is still unmet , Reumatismo: Vol. 72 No. 2 (2020)
- F. Atzeni, M. Turiel, L. Boccassini, S. Sitia, L. Tomasoni, M. Battellino, A. Marchesoni, V. De Gennaro Colonna, P. Sarzi-Puttini, Cardiovascular involvement in psoriatic arthritis , Reumatismo: Vol. 63 No. 3 (2011)
<< < 5 6 7 8 9 10 11 12 13 14 > >>
You may also start an advanced similarity search for this article.
