https://doi.org/10.4081/reumatismo.2024.1764
The pink side of spondyloarthritis: a narrative review across pathogenesis and clinical manifestations in women
Published: 11 September 2024
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Objective. The aim of the present review was to highlight gender and sex differences in spondyloarthritis (SpA) to achieve a better awareness of the unmet needs of women with SpA.
Methods. A literature search of PubMed was performed, including manuscripts in English published in the last twenty years, to select and analyze articles related to SpA and sex and gender differences in epidemiology, genetics, immunology, clinical features, and response to treatment.
Results. Women and men with SpA have different disease phenotypes, and this heterogeneity mirrors anatomical, physiological, and hormonal differences, as well as peculiar variability in response to treatment. These underestimated differences, which include several biological factors and intertwined social factors, contribute to diagnostic delay and increased disease burden in women with SpA.
Conclusions. This review elucidates gender differences in SpA and raises awareness about the need for gender-related stratification of SpA patients with the concomitant implementation of SpA gender differences in future research and upcoming clinical trials. A deeper knowledge of SpA in women is indispensable to pave the way for real personalized medicine for SpA patients to reduce misdiagnosis and delay in intercepting the disease.
Baumberger H, Khan M. SAT0417 Gradual progressive change to equal prevalence of ankylosing spondylitis among males and females in Switzerland: data from the Swiss ankylosing spondylitis society (SVMB). Ann Rheum Dis 2017; 76: 929.1-929.
DOI: https://doi.org/10.1136/annrheumdis-2017-eular.3961
Sieper J, Van Der Heijde D. Review: nonradiographic axial spondyloarthritis: new definition of an old disease?. Arthritis Rheum 2013; 65: 543-51.
DOI: https://doi.org/10.1002/art.37803
Boonen A, Sieper J, Van Der Heijde D, Dougados M, Bukowski JF, Valluri S, et al. The burden of non-radiographic axial spondyloarthritis. Semin Arthritis Rheum 2015; 44: 556-62.
DOI: https://doi.org/10.1016/j.semarthrit.2014.10.009
Garrido-Cumbrera M, Poddubnyy D, Gossec L, Mahapatra R, Bundy C, Makri S, et al. Gender differences in patient journey to diagnosis and disease outcomes: results from the European Map of Axial Spondyloarthritis (EMAS). Clin Rheumatol 2021; 40: 2753-61.
DOI: https://doi.org/10.1007/s10067-020-05558-7
Rusman T, Ten Wolde S, Euser SM, van der Ploeg T, van Hall O, van der Horst-Bruinsma IE. Gender differences in retention rate of tumor necrosis factor alpha inhibitor treatment in ankylosing spondylitis: a retrospective cohort study in daily practice. Int J Rheum Dis 2018; 21: 836-42.
DOI: https://doi.org/10.1111/1756-185X.13271
Marzo-Ortega H, Navarro-Compán V, Akar S, Kiltz U, Clark Z, Nikiphorou E. The impact of gender and sex on diagnosis, treatment outcomes and health-related quality of life in patients with axial spondyloarthritis. Clin Rheumatol 2022; 41: 3573-81.
DOI: https://doi.org/10.1007/s10067-022-06228-6
West HF. Aetiology of ankylosing spondylitis. Ann Rheum Dis 1949; 8: 143-8.
DOI: https://doi.org/10.1136/ard.8.2.143
Mease PJ, McLean RR, Dube B, et al. Comparison of Men and Women With Axial Spondyloarthritis in the US-based Corrona Psoriatic Arthritis/Spondyloarthritis Registry. J Rheumatol 2021;48:1528–36.
DOI: https://doi.org/10.3899/jrheum.201549
Mease PJ, Liu M, Rebello S, Kang H, Yi E, Park Y, et al. Comparative disease burden in patients with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis: data from two corrona registries. Rheumatol Ther 2019; 6: 529-42.
DOI: https://doi.org/10.1007/s40744-019-00172-9
Rusman T, Van Vollenhoven RF, Van Der Horst-Bruinsma IE. Gender differences in axial spondyloarthritis: women are not so lucky. Curr Rheumatol Rep 2018; 20: 35.
DOI: https://doi.org/10.1007/s11926-018-0744-2
Lee W, Reveille JD, Davis JC, Learch TJ, Ward MM, Weisman MH. Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort. Ann Rheum Dis 2007; 66: 633-8.
DOI: https://doi.org/10.1136/ard.2006.060293
Tournadre A, Pereira B, Lhoste A, Dubost JJ, Ristori JM, Claudepierre P, et al. Differences between women and men with recent‐onset axial spondyloarthritis: results from a prospective multicenter French cohort. Arthritis Care Res 2013; 65: 1482-9.
DOI: https://doi.org/10.1002/acr.22001
Eder L, Thavaneswaran A, Chandran V, Gladman DD. Gender difference in disease expression, radiographic damage and disability among patients with psoriatic arthritis. Ann Rheum Dis 2013; 72: 578-82.
DOI: https://doi.org/10.1136/annrheumdis-2012-201357
Duruöz MT, Gezer HH, Nas K, Kılıç E, Sargın B, Acer Kasmanet S, al. Gender-related differences in disease activity and clinical features in patients with peripheral psoriatic arthritis: a multi-center study. Joint Bone Spine 2021; 88: 105177.
DOI: https://doi.org/10.1016/j.jbspin.2021.105177
Scotti L, Franchi M, Marchesoni A, Corrao G. Prevalence and incidence of psoriatic arthritis: a systematic review and meta-analysis. Semin Arthritis Rheum 2018; 48: 28-34.
DOI: https://doi.org/10.1016/j.semarthrit.2018.01.003
Reveille JD. The genetic basis of spondyloarthritis. Ann Rheum Dis 2011; 70: i44-50.
DOI: https://doi.org/10.1136/ard.2010.140574
Brown MA. Recurrence risk modelling of the genetic susceptibility to ankylosing spondylitis. Ann Rheum Dis 2000; 59: 883-6.
DOI: https://doi.org/10.1136/ard.59.11.883
Akassou A, Bakri Y. Does HLA-B27 status influence ankylosing spondylitis phenotype?. Clin Med Insights Arthritis Musculoskelet Disord 2018; 11: 117954411775162.
DOI: https://doi.org/10.1177/1179544117751627
Li Z, Van Der Linden SM, Khan MA, Baumberger H, van Zandwijk H, Khan MK, et al. Heterogeneity of axial spondyloarthritis: genetics, sex and structural damage matter. RMD Open 2022; 8: e002302.
DOI: https://doi.org/10.1136/rmdopen-2022-002302
Wang Q, Zhou X. Associations of MICA polymorphisms with inflammatory rheumatic diseases. Open Rheumatol J 2015; 9: 94-100.
DOI: https://doi.org/10.2174/1874312901409010094
Vecellio M, Cohen CJ, Roberts AR, Wordsworth PB, Kenna TJ. RUNX3 and T-Bet in immunopathogenesis of ankylosing spondylitis-novel targets for therapy? Front Immunol 2018; 9: 3132.
DOI: https://doi.org/10.3389/fimmu.2018.03132
Reveille JD. An update on the contribution of the MHC to as susceptibility. Clin Rheumatol 2014; 33: 749-57.
DOI: https://doi.org/10.1007/s10067-014-2662-7
Gracey E, Yao Y, Green B, Qaiyum Z, Baglaenko Y, Lin A, et al. Sexual dimorphism in the Th17 signature of ankylosing spondylitis. Arthritis Rheumatol 2016; 68: 679-89.
DOI: https://doi.org/10.1002/art.39464
Tsui HW, Inman RD, Paterson AD, Reveille JD, Tsui FWL. ANKH variants associated with ankylosing spondylitis: gender differences. Arthritis Res Ther 2005; 7: R513-25.
DOI: https://doi.org/10.1186/ar1701
Tsui HW, Inman RD, Reveille JD, Tsui FWL. Association of a TNAP haplotype with ankylosing spondylitis. Arthritis Rheum 2007; 56: 234-43.
DOI: https://doi.org/10.1002/art.22307
Chimenti MS, Perricone C, D’Antonio A, Ferraioli M, Conigliaro P, Triggianese P, et al. Genetics, epigenetics, and gender impact in axial-spondyloarthritis susceptibility: an update on genetic polymorphisms and their sex related associations. Front Genet 2021; 12: 671976.
DOI: https://doi.org/10.3389/fgene.2021.671976
Oliveira-Toré CF, Moraes AG, Martinez GF, Neves JSF, Macedo LC, Rocha-Loures MA, et al. Genetic polymorphisms of toll-like receptors 2 and 9 as susceptibility factors for the development of ankylosing spondylitis and psoriatic arthritis. J Immunol Res 2019; 2019: 1492092.
DOI: https://doi.org/10.1155/2019/1492092
Cornelius DC. The role of sex differences in inflammation and autoimmune diseases. sex differences in cardiovascular physiology and pathophysiology. Cambridge, MA: Academic Press, 2019: 205-17.
DOI: https://doi.org/10.1016/B978-0-12-813197-8.00013-0
Rahman P, Gladman DD, Schentag CT, Petronis A. Excessive paternal transmission in psoriatic arthritis. Arthritis Rheum 1999; 42: 1228-31.
DOI: https://doi.org/10.1002/1529-0131(199906)42:6<1228::AID-ANR20>3.0.CO;2-3
Pollock RA, Thavaneswaran A, Pellett F, Chandran V, Petronis A, Rahman P, et al. Further evidence supporting a parent-of-origin effect in psoriatic disease. Arthritis Care Res (Hoboken) 2015; 67: 1586-90.
DOI: https://doi.org/10.1002/acr.22625
Karason A, Gudjonsson JE, Upmanyu R, Antonsdottir AA, Hauksson VB, Runasdottir EH, et al. A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting. Am J Hum Genet 2003; 72: 125-31.
DOI: https://doi.org/10.1086/345646
Cherqaoui B, Crémazy F, Hue C, Garchon HJ, Breban M, Costantino F. Epigenetics of spondyloarthritis. Joint Bone Spine 2020; 87: 565-71.
DOI: https://doi.org/10.1016/j.jbspin.2020.06.003
Oertelt-Prigione S. The influence of sex and gender on the immune response. Autoimmunity Rev 2012; 11: A479-85.
DOI: https://doi.org/10.1016/j.autrev.2011.11.022
Fish EN. The X-files in immunity: sex-based differences predispose immune responses. Nat Rev Immunol 2008; 8: 737-44.
DOI: https://doi.org/10.1038/nri2394
Ito A, Bebo BF, Matejuk A, Zamora A, Silverman M, Fyfe-Johnson A, et al. Estrogen treatment down-regulates tnf-α production and reduces the severity of experimental autoimmune encephalomyelitis in cytokine knockout mice. J Immunol 2001; 167: 542-52.
DOI: https://doi.org/10.4049/jimmunol.167.1.542
Jeong H, Bae EK, Kim H, Eun YH, Kim IY, Kim H, et al. Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model. Arthritis Res Ther 2017; 19: 198.
DOI: https://doi.org/10.1186/s13075-017-1407-9
Nair RS, Priyanka HP. Role of estrogen in neuroimmunomodulation in the periphery and onset of autoimmune dysfunction. Arch Autoim Dis 2021; 1. doi: 10.46439/autoimmune.1.007
DOI: https://doi.org/10.46439/autoimmune.1.007
Jimenez-Balderas FJ, Tapia-Serrano R, Madero-Cervera JI, Murrieta S, Mintz G. Ovarian function studies in active ankylosing spondylitis in women. Clinical response to estrogen therapy. J Rheumatol 1990; 17: 497-502.
Mahendira D, Thavaneswaran A, Carty A, Haroon N, Anton A, Passalent L, et al. Analysis of the effect of the oral contraceptive pill on clinical outcomes in women with ankylosing spondylitis. J Rheumatol 2014; 41: 1344-8.
DOI: https://doi.org/10.3899/jrheum.130996
Schinocca C, Rizzo C, Fasano S, Grasso G, La Barbera L, Ciccia F, et al. Role of the IL-23/IL-17 pathway in rheumatic diseases: an overview. Front Immunol 2021; 12: 637829.
DOI: https://doi.org/10.3389/fimmu.2021.637829
Huang WN, Tso TK, Kuo YC, Tsay GJ. Distinct impacts of syndesmophyte formation on male and female patients with ankylosing spondylitis. Int J Rheum Dis 2012; 15: 163-8.
DOI: https://doi.org/10.1111/j.1756-185X.2011.01687.x
Rizzo A, Guggino G, Ferrante A, Ciccia F. Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis. Front Med (Lausanne) 2018; 5: 63.
DOI: https://doi.org/10.3389/fmed.2018.00063
Rizzo C, Camarda F, Donzella D, La Barbera L, Guggino G. Metabolomics: an emerging approach to understand pathogenesis and to assess diagnosis and response to treatment in spondyloarthritis. Cells 2022; 11: 549.
DOI: https://doi.org/10.3390/cells11030549
Ciccia F, Guggino G, Rizzo A, Alessandro R, Luchetti MM, Milling S, et al. Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis. Ann Rheum Dis 2017; 76: 1123-32.
DOI: https://doi.org/10.1136/annrheumdis-2016-210000
Guggino G, Mauro D, Rizzo A, Alessandro R, Raimondo S, Bergot AS, et al. Inflammasome activation in ankylosing spondylitis is associated with gut dysbiosis. Arthritis Rheumatol 2021; 73: 1189-99.
DOI: https://doi.org/10.1002/art.41644
Cutolo M, Straub RH. Sex steroids and autoimmune rheumatic diseases: state of the art. Nat Rev Rheumatol 2020; 16: 628-44.
DOI: https://doi.org/10.1038/s41584-020-0503-4
Molina N, Sola-Leyva A, Saez-Lara M, Plaza-Diaz J, Tubić-Pavlović A, Romero B, et al. New opportunities for endometrial health by modifying uterine microbial composition: present or future?. Biomolecules 2020; 10: 593.
DOI: https://doi.org/10.3390/biom10040593
Agostinis C, Mangogna A, Bossi F, Ricci G, Kishore U, Bulla R, et al. Uterine immunity and microbiota: a shifting paradigm. Front Immunol 2019; 10: 2387.
DOI: https://doi.org/10.3389/fimmu.2019.02387
Romand X, Liu X, Rahman MA, Bhuyan ZA, Douillard C, Arora Kedia R. Mediation of interleukin‐23 and tumor necrosis factor–driven reactive arthritis by chlamydia ‐infected macrophages in SKG mice. Arthritis Rheum 2021; 73: 1200-10.
DOI: https://doi.org/10.1002/art.41653
Kiltz U, Baraliakos X, Karakostas P, Igelmann M, Kalthoff L, Klink C, et al. Do patients with non‐radiographic axial spondylarthritis differ from patients with ankylosing spondylitis?. Arthritis Care Res 2012; 64: 1415-22.
DOI: https://doi.org/10.1002/acr.21688
Ortolan A, Van Lunteren M, Ramiro S, Ramonda R, Landewé RBM, Dagfinrud H, et al. Are gender-specific approaches needed in diagnosing early axial spondyloarthritis? Data from the SPondyloArthritis Caught Early cohort. Arthritis Res Ther 2018; 20: 218.
DOI: https://doi.org/10.1186/s13075-018-1705-x
Deminger A, Klingberg E, Geijer M, Göthlin J, Hedberg M, Rehnberg E, et al. A five-year prospective study of spinal radiographic progression and its predictors in men and women with ankylosing spondylitis. Arthritis Res Ther 2018; 20: 162.
DOI: https://doi.org/10.1186/s13075-018-1665-1
Slobodin G, Reyhan I, Avshovich N, Balbir-Gurman A, Boulman N, Elias M, et al. Recently diagnosed axial spondyloarthritis: gender differences and factors related to delay in diagnosis. Clin Rheumatol 2011; 30: 1075-80.
DOI: https://doi.org/10.1007/s10067-011-1719-0
Wright GC, Kaine J, Deodhar A. Understanding differences between men and women with axial spondyloarthritis. Semin Arthritis Rheum 2020; 50: 687-94.
DOI: https://doi.org/10.1016/j.semarthrit.2020.05.005
Landi M, Maldonado-Ficco H, Perez-Alamino R, Maldonado-Cocco JA, Citera G, Arturi P, et al. Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an Iberoamerican spondyloarthritis cohort. Medicine 2016; 95: e5652.
DOI: https://doi.org/10.1097/MD.0000000000005652
Jovaní V, Blasco-Blasco M, Ruiz-Cantero MT, Pascual E. Understanding how the diagnostic delay of spondyloarthritis differs between women and men: a systematic review and metaanalysis. J Rheumatol 2017; 44: 174-83.
DOI: https://doi.org/10.3899/jrheum.160825
Salaffi F, De Angelis R, Carotti M, Gutierrez M, Sarzi-Puttini P, Atzeni F. Fibromyalgia in patients with axial spondyloarthritis: epidemiological profile and effect on measures of disease activity. Rheumatol Int 2014; 34: 1103-10.
DOI: https://doi.org/10.1007/s00296-014-2955-9
Mease PJ. Fibromyalgia, a missed comorbidity in spondyloarthritis: prevalence and impact on assessment and treatment. Curr Opin Rheumatol 2017; 29: 304-10.
DOI: https://doi.org/10.1097/BOR.0000000000000388
Montilla C, Díaz-Alvarez A, Calero-Paniagua I, Collantes-Estevez E, Font P, Almodovar R, et al. Ankylosing spondylitis without axial progression: analysis of associated factors. J Rheumatol 2014; 41: 2409-12.
DOI: https://doi.org/10.3899/jrheum.140018
Navarini L, Currado D, Marino A, Di Donato S, Biaggi A, Caso F, et al. Persistence of C-reactive protein increased levels and high disease activity are predictors of cardiovascular disease in patients with axial spondyloarthritis. Sci Rep 2022; 12: 7498.
DOI: https://doi.org/10.1038/s41598-022-11640-8
Gladman DD, Brubacher B, Buskila D, Langevitz P, Farewell VT. Psoriatic spondyloarthropathy in men and women: a clinical, radiographic, and HLA study. Clin Invest Med 1992; 15: 371-5.
Coates LC, van der Horst-Bruinsma IE, Lubrano E, Beaver S, Drane E, Ufuktepe B, et al. Sex-specific differences in patients with psoriatic arthritis: a systematic review. J Rheumatol 2023; 50: 488-96.
DOI: https://doi.org/10.3899/jrheum.220386
Turner DE, Hyslop E, Barn R, McInnes IB, Steultjens MPM, Woodburn J, et al. Metatarsophalangeal joint pain in psoriatic arthritis: a cross-sectional study. Rheumatology 2014; 53: 737-40.
DOI: https://doi.org/10.1093/rheumatology/ket435
Tarannum S, Leung Y-Y, Johnson SR, Widdifield J, Strand V, Rochon P, et al. Sex- and gender-related differences in psoriatic arthritis. Nat Rev Rheumatol 2022;18:513-26.
DOI: https://doi.org/10.1038/s41584-022-00810-7
Lubrano E, Scriffignano S, Fatica M, Triggianese P, Conigliaro P, Perrotta FM, et al. Psoriatic arthritis in males and females: differences and similarities. Rheumatol Ther 2023; 10: 589-99.
DOI: https://doi.org/10.1007/s40744-023-00535-3
Paiva ES, Macaluso DC, Edwards A, Rosenbaum JT. Characterisation of uveitis in patients with psoriatic arthritis. Ann Rheum Dis 2000; 59: 67-70.
DOI: https://doi.org/10.1136/ard.59.1.67
Lukas C, Dougados M, Combe B. Factors associated with a bad functional prognosis in early inflammatory back pain: results from the DESIR cohort. RMD Open 2016; 2: e000204.
DOI: https://doi.org/10.1136/rmdopen-2015-000204
Rusman T, van Bentum RE, van der Horst-Bruinsma IE. Sex and gender differences in axial spondyloarthritis: myths and truths. Rheumatology 2020; 59: iv38-46.
DOI: https://doi.org/10.1093/rheumatology/keaa543
Kilic G, Kilic E, Ozgocmen S. Relationship between psychiatric status, self-reported outcome measures, and clinical parameters in axial spondyloarthritis. Medicine 2014; 93: e337.
DOI: https://doi.org/10.1097/MD.0000000000000337
Zhao S, Thong D, Miller N, Duffield SJ, Hughes DM, Chadwick L, et al. The prevalence of depression in axial spondyloarthritis and its association with disease activity: a systematic review and meta-analysis. Arthritis Res Ther 2018; 20: 140.
DOI: https://doi.org/10.1186/s13075-018-1644-6
Ogdie A, Benjamin Nowell W, Reynolds R, Gavigan K, Venkatachalam S, de la Cruz M, et al. Real-world patient experience on the path to diagnosis of ankylosing spondylitis. Rheumatol Ther 2019; 6: 255-67.
DOI: https://doi.org/10.1007/s40744-019-0153-7
Gok K, Cengiz G, Erol K, Ozgocmen S. Neuropathic pain component in axial spondyloarthritis and the influence on disease burden. J Clin Rheumatol 2018; 24: 324-7.
DOI: https://doi.org/10.1097/RHU.0000000000000711
Gossec L, Berenbaum F, Chauvin P, Lamiraud K, Russo-Marie F, Joubert JM, et al. Reporting of patient-perceived impact of rheumatoid arthritis and axial spondyloarthritis over 10 years: a systematic literature review. Rheumatology 2014; 53: 1274-81.
DOI: https://doi.org/10.1093/rheumatology/ket480
Queiro R, Sarasqueta C, Torre JC, Tinturé T, López-Lagunas I. Comparative analysis of psoriatic spondyloarthropathy between men and women. Rheumatol Int 2001; 21: 66-8.
DOI: https://doi.org/10.1007/s002960100135
Wervers K, Luime JJ, Tchetverikov I, Gerards AH, Kok MR, Appels CWY, et al. Influence of disease manifestations on health-related quality of life in early psoriatic arthritis. J Rheumatol 2018; 45: 1526-31.
DOI: https://doi.org/10.3899/jrheum.171406
Orbai A-M, Perin J, Gorlier C, Coates LC, Kiltz U, Leung YY, et al. Determinants of patient-reported psoriatic arthritis impact of disease: an analysis of the association with sex in 458 patients from fourteen countries. Arthritis Care Res 2020; 72: 1772-9.
DOI: https://doi.org/10.1002/acr.24090
Neuenschwander R, Hebeisen M, Micheroli R, Bürki K, Exer P, Niedermann K, et al. Differences between men and women with nonradiographic axial spondyloarthritis: clinical characteristics and treatment effectiveness in a real-life prospective cohort. Arthritis Res Ther 2020; 22: 233.
DOI: https://doi.org/10.1186/s13075-020-02337-2
Gremese E, Bernardi S, Bonazza S, Nowik M, Peluso G, Massara A, et al. Body weight, gender and response to TNF-α blockers in axial spondyloarthritis. Rheumatology 2014; 53: 875-81.
DOI: https://doi.org/10.1093/rheumatology/ket433
Chimenti MS, Alten R, D’Agostino MA, Gremese E, Kiltz U, Lubrano E, et al. Sex-associated and gender-associated differences in the diagnosis and management of axial spondyloarthritis: addressing the unmet needs of female patients. RMD Open 2021; 7: e001681.
DOI: https://doi.org/10.1136/rmdopen-2021-001681
Chimenti MS, Fonti GL, Conigliaro P, Sunzini F, Scrivo R, Navarini L, et al. One-year effectiveness, retention rate, and safety of secukinumab in ankylosing spondylitis and psoriatic arthritis: a real-life multicenter study. Expert Opin Biol Ther 2020; 20: 813-21.
DOI: https://doi.org/10.1080/14712598.2020.1761957
Ramonda R, Lorenzin M, Carriero A, Chimenti MS, Scarpa R, Marchesoni A, et al. Effectiveness and safety of secukinumab in 608 patients with psoriatic arthritis in real life: a 24-month prospective, multicentre study. RMD Open 2021; 7: e001519.
DOI: https://doi.org/10.1136/rmdopen-2020-001519
Manfreda V, Chimenti MS, Canofari C, Esposito M, Perricone R, Bianchi L, et al. Efficacy and safety of ixekizumab in psoriatic arthritis: a retrospective, single-centre, observational study in a real-life clinical setting. Clin Exp Rheumatol 2020; 38: 581-2.
Coates LC, Mahmood F, Freeston J, Emery P, Conaghan PG, Helliwell PS. Long-term follow-up of patients in the TIght COntrol of inflammation in early Psoriatic Arthritis (TICOPA) trial. Rheumatology 2020; 59: 807-10.
DOI: https://doi.org/10.1093/rheumatology/kez369
Theander E, Husmark T, Alenius GM, Larsson PT, Teleman A, Geijer M, et al. Early psoriatic arthritis: short symptom duration, male gender and preserved physical functioning at presentation predict favourable outcome at 5-year follow-up. Results from the Swedish Early Psoriatic Arthritis Register (SwePsA). Ann Rheum Dis 2014; 73: 407-13.
DOI: https://doi.org/10.1136/annrheumdis-2012-201972
Wervers K, Luime JJ, Tchetverikov I, Gerards AH, Kok MR, Appels CWY, et al. Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis. Arthritis Res Ther 2019; 21: 25.
DOI: https://doi.org/10.1186/s13075-019-1811-4
Scriffignano S, Perrotta FM, Conigliaro P, Ferraioli M, Triggianese P, Chimenti MS, et al. Identification of the Minimal Disease Activity Domains Achieved Based on Different Treatments in Psoriatic Arthritis. Rheumatol Ther 2023; 10: 1785-94.
DOI: https://doi.org/10.1007/s40744-023-00588-4
Navarini L, Currado D, Caso F, Chimenti MS, D’Antonio A, Tasso M, et al. Duration of clinical remission and low disease activity impacts on quality of life and its domains in psoriatic arthritis patients: results from an Italian multicentre study. Clin Exp Rheumatol 2022; 40: 1285-92.
DOI: https://doi.org/10.55563/clinexprheumatol/tgdj0p
How to Cite
Rizzo, C., La Barbera, L., D’Antonio, A., Camarda, F., Conigliaro, P., Chimenti, M., & Guggino, G. (2024). The pink side of spondyloarthritis: a narrative review across pathogenesis and clinical manifestations in women. Reumatismo, 76(3). https://doi.org/10.4081/reumatismo.2024.1764
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