https://doi.org/10.4081/reumatismo.2025.1744
Adherence to vaccination against SARS-CoV-2 and vaccine safety in patients with immunoglobulin G4-related disease
Submitted: 13 May 2024
Accepted: 22 July 2024
Published: 22 January 2025
Accepted: 22 July 2024
Abstract Views: 431
PDF: 88
SUPPLEMENTARY MATERIAL: 16
SUPPLEMENTARY MATERIAL: 16
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Objective. To assess the adherence to the vaccination campaign against SARS-CoV-2 in patients with immunoglobulin-G4-related disease (IgG4-RD) and to evaluate the development of local and systemic adverse events (AEs) following vaccination. Additionally, to investigate the rate and outcome of SARS-CoV-2 infection in IgG4-RD patients.
Methods. Patients with IgG4-RD in follow-up before the onset of the SARS-CoV-2 pandemic were contacted by telephone and asked to answer an ad hoc questionnaire regarding their vaccination status against SARS-CoV-2 and related AEs following vaccination. The occurrence and the outcome of SARS-CoV-2 infection were also recorded. The same questionnaire was proposed to healthy controls (HC).
Results. 20 patients and 40 HC were enrolled. In the patient’s cohort, 90% were vaccinated with at least one dose; among them, 9 reported AEs: 44.4% systemic and 22.2% local. Within the HC group, 100% were vaccinated with at least one dose. 13 out of 40 HC had systemic AEs (50%), and 27 (67.5%) reported local AEs. Neither in IgG4-RD nor in HC, serious adverse reactions were observed. Among the patient’s cohort, 60% contracted SARS-CoV-2 infection, and 41.67% were on immunosuppressants at the time of the infection. One patient presented with severe COVID-19. No disease flares following vaccination or infection were reported.
Conclusions. Results from our study indicate a good adherence to the vaccination campaign against SARS-CoV-2 in patients with IgG4-RD and support a relatively good safety profile of this vaccine. Compared to controls, patients with IgG4-RD reported slightly more systemic AEs and fewer local AEs. A similar rate of COVID-19 development was observed between IgG4-RD patients and HC.
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How to Cite
Mastromanno, L., Giardina, F., Gattamelata, A., Colafrancesco, S., Truglia, S., Spinelli, F. R., … Priori, R. (2025). Adherence to vaccination against SARS-CoV-2 and vaccine safety in patients with immunoglobulin G4-related disease. Reumatismo. https://doi.org/10.4081/reumatismo.2025.1744
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