https://doi.org/10.4081/reumatismo.2024.1699
Retrospective evaluation of the efficacy of ultrasound-guided intra-articular hyaluronic-acid- based injections (Hyalubrix®) in patients with glenohumeral osteoarthritis
Submitted: 25 January 2024
Accepted: 14 July 2024
Published: 16 December 2024
Accepted: 14 July 2024
Abstract Views: 498
PDF: 155
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Objective. Intra-articular injections of hyaluronic acid (HA) have been reported to alleviate pain, reduce disability, and improve joint function in glenohumeral osteoarthritis (GH-OA). This retrospective study aimed to evaluate the effectiveness of a HA-based formulation (Hyalubrix®) in reducing the pain of patients with GH-OA and improving both patient's shoulder functions and quality of life (QoL).
Methods. Data collected during the standard clinical practice of the center was retrospectively analyzed. The Simple Shoulder Test (SST) questionnaire reported data on the patient's ability to perform daily activities; the Euro-Quality of Life Health Assessment (EQ-5D) collected evidence on QoL; and changes in pain were evaluated through the Visual Analog Scale (VAS). SST and EQ-5D scores were analyzed comparing baseline values with those at the last follow-up, while VAS was investigated for all the available visits. Continuous values were summarized as mean ± standard deviation, median, and 25-75th percentiles. Shapiro-Wilk test assessed normality, with significance set at p<0.05, and no adjustments for multiple comparisons were made.
Results. All scores showed a significant improvement: VAS decreased from 55.4±13.8 to 16.2±16.3 (p<0.001), the SST increased from 38.0 to 65.5 (p<0.001), as well as the EQ-5D (from 41.7 to 76.7; p<0.001).
Conclusions. GH-OA treatment with Hyalubrix® proved to be highly beneficial, leading to complete pain reduction in more than 50% of patients and a significant reduction in 27.5% of cases. This resulted in improved joint function and QoL.
Issa SN, Sharma L. Epidemiology of osteoarthritis: an update. Curr Rheumatol Rep 2006; 8: 7-15.
DOI: https://doi.org/10.1007/s11926-006-0019-1
Neogi T, Zhang Y. Epidemiology of osteoarthritis. Rheum Dis Clin North Am 2013; 39: 1-19.
DOI: https://doi.org/10.1016/j.rdc.2012.10.004
Chillemi C, Franceschini V. Shoulder osteoarthritis. Arthritis 2013; 2013: 370231.
DOI: https://doi.org/10.1155/2013/370231
Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med 2010; 26: 355-69. Erratum in: Clin Geriatr Med 2013; 29: ix.
DOI: https://doi.org/10.1016/j.cger.2010.03.001
Thomas M, Bidwai A, Rangan A, Rees JL, Brownson P, Tennent D, et al. Glenohumeral osteoarthritis. Shoulder Elbow 2016; 8: 203-14.
DOI: https://doi.org/10.1177/1758573216644183
Kobayashi T, Takagishi K, Shitara H, Ichinose T, Shimoyama D, Yamamoto A, et al. Prevalence of and risk factors for shoulder osteoarthritis in Japanese middle-aged and elderly populations. J Shoulder Elbow Surg 2014; 23: 613-9.
DOI: https://doi.org/10.1016/j.jse.2013.11.031
Oh JH, Chung SW, Oh CH, Kim SH, Park SJ, Kim KW, et al. The prevalence of shoulder osteoarthritis in the elderly Korean population: association with risk factors and function. J Shoulder Elbow Surg 2011; 20: 756-63.
DOI: https://doi.org/10.1016/j.jse.2011.01.021
Kerr R, Resnick D, Pineda C, Haghighi P. Osteoarthritis of the glenohumeral joint: a radiologic-pathologic study. AJR Am J Roentgenol 1985; 144: 967-72.
DOI: https://doi.org/10.2214/ajr.144.5.967
Sperling JW, Hawkins RJ, Walch G, Mahoney AP, Zuckerman JD. Complications in total shoulder arthroplasty. Instr Course Lect 2013; 62: 135-41.
DOI: https://doi.org/10.2106/00004623-201303200-00012
van de Sande MA, Brand R, Rozing PM. Indications, complications, and results of shoulder arthroplasty. Scand J Rheumatol 2006; 35: 426-34.
DOI: https://doi.org/10.1080/03009740600759720
Al-Mohrej OA, Prada C, Leroux T, Shanthanna H, Khan M. Pharmacological treatment in the management of glenohumeral osteoarthritis. Drugs Aging 2022; 39: 119-28.
DOI: https://doi.org/10.1007/s40266-021-00916-9
Costa FR, Costa Marques MR, Costa VC, Santos GS, Martins RA, Santos MDS, et al. Intra-articular hyaluronic acid in osteoarthritis and tendinopathies: molecular and clinical approaches. Biomedicines 2023; 11: 1061.
DOI: https://doi.org/10.3390/biomedicines11041061
Strauss EJ, Hart JA, Miller MD, Altman RD, Rosen JE. Hyaluronic acid viscosupplementation and osteoarthritis: current uses and future directions. Am J Sports Med 2009; 37: 1636-44.
DOI: https://doi.org/10.1177/0363546508326984
Patti AM, Gabriele A, Vulcano A, Ramieri MT, Della Rocca C. Effect of hyaluronic acid on human chondrocyte cell lines from articular cartilage. Tissue Cell 2001; 33: 294-300.
DOI: https://doi.org/10.1054/tice.2001.0178
Dahl LB, Dahl IM, Engström-Laurent A, Granath K. Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies. Ann Rheum Dis 1985; 44: 817-22.
DOI: https://doi.org/10.1136/ard.44.12.817
Blaine T, Moskowitz R, Udell J, Skyhar M, Levin R, Friedlander J, et al. Treatment of persistent shoulder pain with sodium hyaluronate: a randomized, controlled trial. A multicenter study. J Bone Joint Surg Am 2008; 90:970-9.
DOI: https://doi.org/10.2106/JBJS.F.01116
Di Giacomo G, de Gasperis N. Hyaluronic acid intra-articular injections in patients affected by moderate to severe glenohumeral osteoarthritis: a prospective randomized study. Joints 2017; 5: 138-42.
DOI: https://doi.org/10.1055/s-0037-1605389
Di Giacomo G, de Gasperis N. Glenohumeral osteoarthritis treatment with a single hyaluronic acid administration: clinical outcomes. J Biol Regul Homeost Agents 2021; 35: 657-61.
Kwon YW, Eisenberg G, Zuckerman JD. Sodium hyaluronate for the treatment of chronic shoulder pain associated with glenohumeral osteoarthritis: a multicenter, randomized, double-blind, placebo-controlled trial. J Shoulder Elbow Surg 2013; 22: 584-94.
DOI: https://doi.org/10.1016/j.jse.2012.10.040
Merolla G, Bianchi P, Porcellini G. Ultrasound-guided subacromial injections of sodium hyaluronate for the management of rotator cuff tendinopathy: a prospective comparative study with rehabilitation therapy. Musculoskelet Surg 2013; 97: 49-56.
DOI: https://doi.org/10.1007/s12306-013-0259-y
Porcellini G, Merolla G, Giordan N, Paladini P, Burini A, Cesari E, et al. Intra-articular glenohumeral injections of HYADD®4-G for the treatment of painful shoulder osteoarthritis: a prospective multicenter, open-label trial. Joints 2016; 3: 116-21.
DOI: https://doi.org/10.11138/jts/2015.3.3.116
Weil AJ. High molecular weight hyaluronan for treatment of chronic shoulder pain associated with glenohumeral arthritis. Med Devices 2011; 4: 99-105.
DOI: https://doi.org/10.2147/MDER.S22423
Migliore A, Tormenta S, Martin Martin LS, Iannessi F, Massafra U, Carloni E, et al. The symptomatic effects of intra-articular administration of hylan G-F 20 on osteoarthritis of the hip: clinical data of 6 months follow-up. Clin Rheumatol 2006; 25: 389-93.
DOI: https://doi.org/10.1007/s10067-005-0052-x
Phiphobmongkol V, Sudhasaneya V. The effectiveness and safety of intra-articular injection of sodium hyaluronate (500-730 kDa) in the treatment of patients with painful knee osteoarthritis. J Med Assoc Thai 2009; 92: 1287-94.
Stitik TP, Blacksin MF, Stiskal DM, Kim JH, Foye PM, Schoenherr L, et al. Efficacy and safety of hyaluronan treatment in combination therapy with home exercise for knee osteoarthritis pain. Arch Phys Med Rehabil 2007; 88: 135-41.
DOI: https://doi.org/10.1016/j.apmr.2006.11.006
Giarratana LS, Marelli BM, Crapanzano C, De Martinis SE, Gala L, Ferraro M, et al. A randomized double-blind clinical trial on the treatment of knee osteoarthritis: the efficacy of polynucleotides compared to standard hyaluronian viscosupplementation. Knee 2014; 21: 661-8.
DOI: https://doi.org/10.1016/j.knee.2014.02.010
Mauro GL, Sanfilippo A, Scaturro D. The effectiveness of intra-articular injections of Hyalubrix® combined with exercise therapy in the treatment of hip osteoarthritis. Clin Cases Miner Bone Metab 2017; 14: 146-52.
DOI: https://doi.org/10.11138/ccmbm/2017.14.1.146
Migliore A, Massafra U, Frediani B, Bizzi E, Sinelnikov Yzchaki E, et al. HyalOne® in the treatment of symptomatic hip OA - data from the ANTIAGE register: seven years of observation. Eur Rev Med Pharmacol Sci 2017; 21: 1635-44.
Foti C, Cisari C, Carda S, Giordan N, Rocco A, Frizziero A, et al. A prospective observational study of the clinical efficacy and safety of intra-articular sodium hyaluronate in synovial joints with osteoarthritis. Eur J Phys Rehabil Med 2011; 47: 407-15.
Colen S, Geervliet P, Haverkamp D, Van Den Bekerom MP. Intra-articular infiltration therapy for patients with glenohumeral osteoarthritis: a systematic review of the literature. Int J Shoulder Surg 2014; 8: 114-21.
DOI: https://doi.org/10.4103/0973-6042.145252
Zhang B, Thayaparan A, Horner N, Bedi A, Alolabi B, Khan M. Outcomes of hyaluronic acid injections for glenohumeral osteoarthritis: a systematic review and meta-analysis. J Shoulder Elbow Surg 2019; 28: 596-606.
DOI: https://doi.org/10.1016/j.jse.2018.09.011
McKee MD, Litchfield R, Hall JA, Wester T, Jones J, Harrison AJ. NASHA hyaluronic acid for the treatment of shoulder osteoarthritis: a prospective, single-arm clinical trial. Med Devices 2019; 12: 227-34.
DOI: https://doi.org/10.2147/MDER.S189522
How to Cite
Monti, L., Franchi, E., Verde, F., Sgherzi, S., & Anghilieri, F. (2024). Retrospective evaluation of the efficacy of ultrasound-guided intra-articular hyaluronic-acid- based injections (Hyalubrix<sup>®</sup>) in patients with glenohumeral osteoarthritis. Reumatismo. https://doi.org/10.4081/reumatismo.2024.1699
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