https://doi.org/10.4081/reumatismo.2024.1697
Pregnancy in patients affected by axial-spondyloarthritis: a narrative review of disease activity and obstetric outcomes
Published: 11 September 2024
Abstract Views: 474
PDF: 221
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Objective. This review aims to summarize the most recent and updated data on pregnancy in patients with axial spondyloarthritis (axSpA), focusing on the recurrence of pregnancy-related complications, the disease activity throughout gestation and the postpartum, and the latest indications for the treatments of future mothers.
Methods. We have conducted a narrative review with an online literature search on Medline and PubMed. We selected only studies written in English published until January 2024, including observational and retrospective studies, meta-analyses, and systematic reviews.
Results. Proper preconception counseling and maternal-fetal monitoring are necessary to ensure the best outcome for both the mother and her baby. Despite the limited and conflicting evidence about the prevalence of adverse pregnancy outcomes in women with axSpA compared to healthy controls, primary findings demonstrate an increased risk of preterm delivery (PTD), low birth weight (LBW), and elective cesarean section (CS). Concerning disease activity, data suggests that 25-80% of women with ankylosing spondylitis experience disease flares during pregnancy, particularly around 20 weeks of gestation. On the contrary, the data on the postpartum disease flare are heterogeneous. The use of biological drugs in pregnancy is safe and effective in controlling disease activity.
Conclusions. Data on pregnancy outcomes in patients with axSpA are scarce and discordant. Probably the difference in maternal disease classification, the evolution of treatment indications, and the differences emerging from study designs can account for these discrepancies. The main evidence shows an increased risk of PTD, LBW, and elective CS (although the latter may reflect cultural influences rather than medical needs due to axSpA itself). The majority of drugs used to treat axSpA, including TNFi, are safe in pregnancy without harming mothers or fetuses. Further data is needed to clarify many controversial aspects in this area.
Ward MM, Deodhar A, Akl EA, Lui A, Ermann J, Gensler LS, et al. American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 recommendations for the treatment of ankylosing spondylitis and nonradiographic axial spondyloarthritis. Arthritis Rheumatol 2016; 68: 282-98.
DOI: https://doi.org/10.1002/art.39298
Sammaritano LR. Pregnancy in rheumatic disease patients. J Clin Rheumatol 2013; 19: 259-66.
DOI: https://doi.org/10.1097/RHU.0b013e31829ce35f
Lee W, Reveille JD, Weisman MH, et al. Women with ankylosing spondylitis: a review. Arthritis Rheum 2008; 59: 449-54.
DOI: https://doi.org/10.1002/art.23321
Ostensen M, Ostensen H. Ankylosing spondylitis--the female aspect. J Rheumatol 1998; 25: 120-4.
Sieper J, Poddubnyy D. Axial spondyloarthritis. Lancet 2017; 390: 73-84.
DOI: https://doi.org/10.1016/S0140-6736(16)31591-4
Maguire S, Wilson F, Gallagher P, Ms Mohamed M, Maher S, O’Shea F. What to expect when women with axial spondyloarthritis are expecting: prevalence of complications of pregnancies in women with axial spondyloarthritis. Semin Arthritis Rheum 2022; 54: 151993.
DOI: https://doi.org/10.1016/j.semarthrit.2022.151993
Zbinden A, van den Brandt S, Østensen M, Villiger PM, Förger F. Risk for adverse pregnancy outcome in axial spondyloarthritis and rheumatoid arthritis: disease activity matters. Rheumatology 2018; 57: 1235-42.
DOI: https://doi.org/10.1093/rheumatology/key053
Lui NL, Haroon N, Carty A, Shen H, Cook RJ, Shanmugarajah S, et al. Effect of pregnancy on ankylosing spondylitis: a case-control study. J Rheumatol 2011; 38: 2442-4.
DOI: https://doi.org/10.3899/jrheum.101174
Ostensen M, Husby G. Pregnancy and rheumatic disease. A review of recent studies in rheumatoid arthritis and ankylosing spondylitis. Klin Wochenschr 1984; 62: 891-5.
DOI: https://doi.org/10.1007/BF01727437
Giles I, Yee CS, Gordon C. Stratifying management of rheumatic disease for pregnancy and breastfeeding. Nat Rev Rheumatol 2019; 15: 391-402.
DOI: https://doi.org/10.1038/s41584-019-0240-8
Smith CJFF, Bandoli G, Kavanaugh A, Chambers CD. Birth outcomes and disease activity during pregnancy in a prospective cohort of women with psoriatic arthritis and ankylosing spondylitis. Arthritis Care Res 2020; 72: 1029-37.
DOI: https://doi.org/10.1002/acr.23924
Morin M, Frisell T, Stephansson O, Hellgren K. Temporal trends in adverse pregnancy outcomes in axial spondyloarthritis in Sweden: a cohort study. Lancet Rheumatol 2023; 5: e121-9.
DOI: https://doi.org/10.1016/S2665-9913(23)00001-2
Ostensen M, Husby G. A prospective clinical study of the effect of pregnancy on rheumatoid arthritis and ankylosing spondylitis. Arthritis Rheum 1983; 26: 1155-9.
DOI: https://doi.org/10.1002/art.1780260915
Ostensen M, Romberg O, Husby G. Ankylosing spondylitis and motherhood. Arthritis Rheum 1982; 25: 140-3.
DOI: https://doi.org/10.1002/art.1780250204
Timur H, Tokmak A, Türkmen GG, İnal HA, Uygur D, Danışman N. Pregnancy outcome in patients with ankylosing spondylitis. J Matern Fetal Neonatal Med 2016; 29: 2470-4.
DOI: https://doi.org/10.3109/14767058.2015.1089432
Ursin K, Lydersen S, Skomsvoll JF, Wallenius M. Disease activity during and after pregnancy in women with axial spondyloarthritis: a prospective multicentre study. Rheumatology 2018; 57: 1064-71.
DOI: https://doi.org/10.1093/rheumatology/key047
Jakobsson GL, Stephansson O, Askling J, Jacobsson LTH. Pregnancy outcomes in patients with ankylosing spondylitis: a nationwide register study. Ann Rheum Dis 2016; 75: 1838-42.
DOI: https://doi.org/10.1136/annrheumdis-2015-207992
Maguire S, O’Dwyer T, Mockler D, O’Shea F, Wilson F. Pregnancy in axial spondyloarthropathy: a systematic review & meta-analysis. Semin Arthritis Rheum 2020; 50; 1269-79.
DOI: https://doi.org/10.1016/j.semarthrit.2020.08.011
Zhou Q, Bian X, Liu J. Management of pregnancy with ankylosing spondylitis. Chin Med Sci J 2012; 27: 46-9.
DOI: https://doi.org/10.1016/S1001-9294(12)60022-4
Förger F, Ostensen M, Schumacher A, Villiger P. Impact of pregnancy on health related quality of life evaluated prospectively in pregnant women with rheumatic diseases by the SF-36 health survey. Ann Rheum Dis 2005; 64: 1494-9.
DOI: https://doi.org/10.1136/ard.2004.033019
Förger F, Villiger PM, Ostensen M. Pregnancy in patients with ankylosing spondylitis: do regulatory T cells play a role?. Arthritis Rheum 2009; 61: 279-83.
DOI: https://doi.org/10.1002/art.24161
Boerma T, Ronsmans C, Melesse DY, Barros AJD, Barros FC, Juan L, et al. Global epidemiology of use of and disparities in caesarean sections. Lancet 2018; 392: 1341-8.
DOI: https://doi.org/10.1016/S0140-6736(18)31928-7
Rito AI, Buoncristiano M, Spinelli A, Salanave B, Kunešová M, Hejgaard T, et al, Association between characteristics at birth, breastfeeding and obesity in 22 countries: the WHO European Childhood Obesity Surveillance Initiative - COSI 2015/2017. Obes Facts 2019; 12: 226-43.
DOI: https://doi.org/10.1159/000500425
Ibanez G, Martin N, Denantes M, Saurel-Cubizolles MJ, Ringa V, Magnier AM. Prevalence of breastfeeding in industrialized countries. Rev Epidemiol Sante Publique 2012; 60: 305-20.
DOI: https://doi.org/10.1016/j.respe.2012.02.008
Østensen M, Andreoli L, Brucato A, Cetin I, Chambers C, Clowse MEB, et al. State of the art: Reproduction and pregnancy in rheumatic diseases. Autoimmun Rev 2015; 14: 376-86.
DOI: https://doi.org/10.1016/j.autrev.2014.12.011
Clowse MEB, Chakravarty E, Costenbader KH, Chambers C, Michaud K. Effects of infertility, pregnancy loss, and patient concerns on family size of women with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Care Res 2012; 64: 668-74.
DOI: https://doi.org/10.1002/acr.21593
Mokbel A, Lawson DO, Farrokhyar F. Pregnancy outcomes in women with ankylosing spondylitis: a scoping literature and methodological review. Clin Rheumatol 2021; 40: 3465-80.
DOI: https://doi.org/10.1007/s10067-021-05588-9
Keeling SO, Oswald AE. Pregnancy and rheumatic disease: “by the book” or “by the doc”. Clin Rheumatol 2009; 28: 1-9.
DOI: https://doi.org/10.1007/s10067-008-1031-9
Helland Y, Dagfinrud H, Kvien TK. Perceived influence of health status on sexual activity in RA patients: associations with demographic and disease-related variables. Scand J Rheumatol 2008; 37: 194-9.
DOI: https://doi.org/10.1080/03009740701867349
Khnaba D, Rostom S, Lahlou R, Bahiri R, Abouqal R, Hajjaj-Hassouni N. Sexual dysfunction and its determinants in Moroccan women with rheumatoid arthritis. Pan Afr Med J 2016; 24: 16.
DOI: https://doi.org/10.11604/pamj.2016.24.16.9081
Hansen KR, Knowlton NS, Thyer AC, Charleston JS, Soules MR, Klein NA. A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod 2008; 23: 699-708.
DOI: https://doi.org/10.1093/humrep/dem408
Østensen M. Sexual and reproductive health in rheumatic disease. Nat Rev Rheumatol 2017; 13: 485-93.
DOI: https://doi.org/10.1038/nrrheum.2017.102
Eudy AM, Siega-Riz AM, Engel SM, Franceschini N, Green Howard A, Clowse MED, et al. Effect of pregnancy on disease flares in patients with systemic lupus erythematosus. Ann Rheum Dis 2018; 77: 855-60.
DOI: https://doi.org/10.1136/annrheumdis-2017-212535
Mørk S, Voss A, Möller S, Bliddal M. Spondyloarthritis and outcomes in pregnancy and labor: a nationwide register-based cohort study. Arthritis Care Res 2021; 73: 282-8.
DOI: https://doi.org/10.1002/acr.24111
Redeker I, Strangfeld A, Callhoff J, Marschall U, Zink A, Baraliakos X. Maternal and infant outcomes in pregnancies of women with axial spondyloarthritis compared with matched controls: results from nationwide health insurance data. RMD Open 2022; 8: e002146.
DOI: https://doi.org/10.1136/rmdopen-2021-002146
Hamroun S, Hamroun A, Bigna JJ, Allado E, Förger F, Molto A. Fertility and pregnancy outcomes in women with spondyloarthritis: a systematic review and meta-analysis. Rheumatology 2022; 61: 1314-27.
DOI: https://doi.org/10.1093/rheumatology/keab589
Bernardy C, Baillet A, Gaudin P, Romand X. Comment on the article by Maguire et al. pregnancy in axial spondyloarthropathy: a systematic review & meta-analysis. Semin Arthritis Rheum 2022; 52: 151845.
DOI: https://doi.org/10.1016/j.semarthrit.2021.05.005
Unal C, Fadiloglu E, Tanacan A, Zaim OC, Beksac MS. Retrospective evaluation of pregnancies with ankylosing spondylitis in a tertiary center in Turkey. Int J Rheum Dis 2020; 23: 101-5.
DOI: https://doi.org/10.1111/1756-185X.13746
Meissner Y, Strangfeld A, Molto A, Forger F, Wallenius M, Costedoat-Chalumeau N, et al. Pregnancy and neonatal outcomes in women with axial spondyloarthritis: pooled data analysis from the European Network of Pregnancy Registries in Rheumatology (EuNeP). Ann Rheum Dis 2022; 81: 1524-33.
DOI: https://doi.org/10.1136/ard-2022-222641
Fuchs F, Monet B, Ducruet T, Chaillet N, Audibert F. Effect of maternal age on the risk of preterm birth: a large cohort study. PloS One 2018; 13: e0191002.
DOI: https://doi.org/10.1371/journal.pone.0191002
Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371: 75-84.
DOI: https://doi.org/10.1016/S0140-6736(08)60074-4
Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet M, Lumbiganon P. The global epidemiology of preterm birth. Best Pract Res Clin Obstet Gynaecol 2018; 52: 3-12.
DOI: https://doi.org/10.1016/j.bpobgyn.2018.04.003
BrownMA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, et al. Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice. Hypertension 2018; 72: 24-43.
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.117.10803
Mol BWJ, Roberts CT, Thangaratinam S, Magee LA, de Groot CJM, Hofmeyr GJ. Pre-eclampsia. Lancet 2016; 387: 999-1011.
DOI: https://doi.org/10.1016/S0140-6736(15)00070-7
Redman CWG, Sargent IL. Immunology of pre-eclampsia. Am J Reprod Immunol 2010; 63: 534-43.
DOI: https://doi.org/10.1111/j.1600-0897.2010.00831.x
Wadström H, Eriksson JK, Neovius M, Askling J. How good is the coverage and how accurate are exposure data in the Swedish Biologics Register (ARTIS)?. Scand J Rheumatol 2015; 44: 22-8.
DOI: https://doi.org/10.3109/03009742.2014.927918
Ibfelt EH, Jensen DV, Hetland ML. The Danish nationwide clinical register for patients with rheumatoid arthritis: DANBIO. Clin Epidemiol 2016; 8: 737-42.
DOI: https://doi.org/10.2147/CLEP.S99490
Pape Secher AE, Granath F, Glintborg B, Rom A, Hetland ML, Hellgren K. Risk of pre-eclampsia and impact of disease activity and antirheumatic treatment in women with rheumatoid arthritis, axial spondylarthritis and psoriatic arthritis: a collaborative matched cohort study from Sweden and Denmark. RMD Open 2022; 8: e002445.
DOI: https://doi.org/10.1136/rmdopen-2022-002445
Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, Cervera R, Costedoat-Chalumeau N, et al. EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis 2017; 76: 476-85.
DOI: https://doi.org/10.1136/annrheumdis-2016-209770
Onno Teng YK, Bredewold EOW, Rabelink TJ, HuizingaTWJ, Jeroen Eikenboom HC, Limper M. An evidence-based approach to pre-pregnancy counselling for patients with systemic lupus erythematosus. Rheumatology 2018; 57: 1707-20.
DOI: https://doi.org/10.1093/rheumatology/kex374
Espinoza J, Kusanovic JP, Bahado-Singh R, Gervasi MT, Romero R, Lee W, et al. Should bilateral uterine artery notching be used in the risk assessment for preeclampsia, small-for-gestational-age, and gestational hypertension?. J Ultrasound Med 2010; 29: 1103-15.
DOI: https://doi.org/10.7863/jum.2010.29.7.1103
Park EH, Lee JS, Kim Y, Lee SM, Jun JK, Lee EB, et al. Pregnancy outcomes in Korean women with ankylosing spondylitis. Korean J Intern Med 2021; 36: 721-30.
DOI: https://doi.org/10.3904/kjim.2019.144
Skomsvoll JF, Ostensen M, Baste V, Irgens LM. Number of births, interpregnancy interval, and subsequent pregnancy rate after a diagnosis of inflammatory rheumatic disease in Norwegian women. J Rheumatol 2001; 28: 2310-4.
van den Brandt S, Zbinden A, Baeten D, Villiger PM, Østensen M, Förger F. Risk factors for flare and treatment of disease flares during pregnancy in rheumatoid arthritis and axial spondyloarthritis patients. Arthritis Res Ther 2017; 19: 64.
DOI: https://doi.org/10.1186/s13075-017-1269-1
Declercq E, Menacker F, MacDorman M. Maternal risk profiles and the primary cesarean rate in the United States, 1991-2002. Am J Public Health 2006; 96: 867-72.
DOI: https://doi.org/10.2105/AJPH.2004.052381
Thuillier C, Roy S, Peyronnet V, Quibel T, Nlandu A, Rozenberg P. Impact of recommended changes in labor management for prevention of the primary cesarean delivery. Am J Obstet Gynecol 2018; 218: 341.e1-e9.
DOI: https://doi.org/10.1016/j.ajog.2017.12.228
Tsao NW, Rebic N, Lynd LD, De Vera MA. Maternal and neonatal outcomes associated with biologic exposure before and during pregnancy in women with inflammatory systemic diseases: a systematic review and meta-analysis of observational studies. Rheumatology 2020; 59: 1808-17.
DOI: https://doi.org/10.1093/rheumatology/keaa064
Bröms G, Kieler H, Ekbom A, Gissler M, Hellgren K, Leinonen MK. Paediatric infections in the first 3 years of life after maternal anti-TNF treatment during pregnancy. Aliment Pharmacol Ther 2020; 52: 843-54.
DOI: https://doi.org/10.1111/apt.15971
Jethwa H, Lam S, Smith C, Giles I. Does rheumatoid arthritis really improve during pregnancy? A systematic review and metaanalysis. J Rheumatol 2019; 46: 245-50.
DOI: https://doi.org/10.3899/jrheum.180226
Ursin K, Lydersen S, Skomsvoll JF, Wallenius M. Psoriatic arthritis disease activity during and after pregnancy: a prospective multicenter study. Arthritis Care Res 2019; 71: 1092-100.
DOI: https://doi.org/10.1002/acr.23747
Østensen M, Fuhrer L, Mathieu R, Seitz M, Villiger PM. A prospective study of pregnant patients with rheumatoid arthritis and ankylosing spondylitis using validated clinical instruments. Ann Rheum Dis 2004; 63: 1212-7.
DOI: https://doi.org/10.1136/ard.2003.016881
Tham M, Schlör GR, Yerly D, Mueller C, Surbek D, Villiger PM, et al. Reduced pro-inflammatory profile of γδT cells in pregnant patients with rheumatoid arthritis. Arthritis Res Ther 2016; 18: 26.
DOI: https://doi.org/10.1186/s13075-016-0925-1
de Man YA, Dolhain RJEM, van de Geijn FE, Willemsen SP, Hazes JMW. Disease activity of rheumatoid arthritis during pregnancy: results from a nationwide prospective study. Arthritis Rheum 2008; 59: 1241-8.
DOI: https://doi.org/10.1002/art.24003
Lockshin MD, Reinitz E, Druzin ML, Murrman M, Estes D. Lupus pregnancy. Case-control prospective study demonstrating absence of lupus exacerbation during or after pregnancy. Am J Med 1984; 77: 893-8.
DOI: https://doi.org/10.1016/0002-9343(84)90538-2
Ostensen M. The effect of pregnancy on ankylosing spondylitis, psoriatic arthritis, and juvenile rheumatoid arthritis. Am J Reprod Immunol 1992; 28: 235-7.
DOI: https://doi.org/10.1111/j.1600-0897.1992.tb00801.x
Østensen M, Förger F, Nelson JL, Schuhmacher A, Hebisch G, Villiger PM. Pregnancy in patients with rheumatic disease: anti-inflammatory cytokines increase in pregnancy and decrease post partum. Ann Rheum Dis 2005; 64: 839-44.
DOI: https://doi.org/10.1136/ard.2004.029538
Ostensen M. The influence of pregnancy on blood parameters in patients with rheumatic disease. Scand J Rheumatol 1984; 13: 203-8.
DOI: https://doi.org/10.3109/03009748409100388
Nalli C, Manfredi L, Fredi M, Crisafulli F, Bertocchi S, amilya Khizroeva J, et al. Managing puerperium in patients with systemic autoimmune diseases: an update. Expert Rev Clin Immunol 2022; 18; 391-9.
DOI: https://doi.org/10.1080/1744666X.2022.2050216
Hainline B. Low-back pain in pregnancy. Adv Neurol 1994; 64: 65-76.
Andreoli L, Gerardi MC, Fernandes M, Bortoluzzi A, Bellando-Randone S, Brucato A, et al. Disease activity assessment of rheumatic diseases during pregnancy: a comprehensive review of indices used in clinical studies. Autoimmun Rev 2019; 18: 164-76.
DOI: https://doi.org/10.1016/j.autrev.2018.08.008
Russell MD, Dey M, Flint J, Davie P, Allen A, Crossley A, et al. British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids. Rheumatology 2023; 62: e48-88.
DOI: https://doi.org/10.1093/rheumatology/keac686
Schreiber K, Frishman M, Russell MD, Dey M, Flint J, Allen A, et al. British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice. Rheumatology 2023; 62: e89-104.
DOI: https://doi.org/10.1093/rheumatology/keac700
Sammaritano LR, Bermas BL, Chakravarty EE, Chambers C, Clowse MEB, D Lockshin MD, et al. 2020 American College of Rheumatology guideline for the management of reproductive health in rheumatic and musculoskeletal diseases. Arthritis Rheumatol 2020; 72: 529-56.
DOI: https://doi.org/10.1002/art.41191
Skorpen CG, Hoeltzenbein M, Tincani A, Fischer-Betz R, Elefant E, Chambers C, et al. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis 2016; 75: 795-810.
DOI: https://doi.org/10.1136/annrheumdis-2015-208840
SIR. Recommendations of the Italian Society of Rheumatology on the reproductive health of patients with rheumatological diseases, available on the website of the Italian National Institute of Health. Available from: https://www.reumatologia.it/obj/files/lineeguida/LG_C006_SIR_SRMR.pd. [Material in Italian].
Ramiro S, Nikiphorou E, Sepriano A, Ortolan A, Webers C, Baraliakos X, et al. ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update. Ann Rheum Dis 2023; 82: 19-34.
DOI: https://doi.org/10.1136/ard-2022-223296
Lindström U, Olofsson T, Wedrén S, Qirjazo I, Askling J. Biological treatment of ankylosing spondylitis: a nationwide study of treatment trajectories on a patient level in clinical practice», Arthritis Res. Ther., vol. 21, fasc. 1, p. 128, mag. 2019, doi: 10.1186/s13075-019-1908-9.
DOI: https://doi.org/10.1186/s13075-019-1908-9
Komaki F, Komaki Y, Micic D, Ido A, Sakuraba A. Outcome of pregnancy and neonatal complications with anti-tumor necrosis factor-α use in females with immune mediated diseases; a systematic review and meta-analysis. J Autoimmun 2017; 76: 38-52.
DOI: https://doi.org/10.1016/j.jaut.2016.11.004
Binns C, Lee M, Low WY. The long-term public health benefits of breastfeeding. Asia Pac J Public Health 2016; 28: 7-14.
DOI: https://doi.org/10.1177/1010539515624964
How to Cite
Filippini, M., Fontana, G., Bizioli, P., Crisafulli, F., Orabona, R., Zatti, S., … Tincani, A. (2024). Pregnancy in patients affected by axial-spondyloarthritis: a narrative review of disease activity and obstetric outcomes. Reumatismo, 76(3). https://doi.org/10.4081/reumatismo.2024.1697
Copyright (c) 2024 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- Y. Emad, T. Gheita, H. Darweesh, P. Klooster, R. Gamal, H. Fathi, N. El-Shaarawy, M. Gamil, M. Hawass, R.M. El-Refai, H. Al-Hanafi, S. Abd-Ellatif, A. Ismail, J. Rasker, Antibodies to extractable nuclear antigens (ENAS) in systemic lupus erythematosus patients: correlations with clinical manifestations and disease activity , Reumatismo: Vol. 70 No. 2 (2018)
- M. Romano, I. Pontikaki, M. Gattinara, I. Ardoino, C. Donati, P. Boracchi, P.L. Meroni, V. Gerloni, Drug survival and reasons for discontinuation of the first course of biological therapy in 301 juvenile idiopathic arthritis patients , Reumatismo: Vol. 65 No. 6 (2013)
- E. Cipriano, F. Ceccarelli, L. Massaro, F. R. Spinelli, C. Alessandri, C. Perricone, G. Valesini, F. Conti, Joint involvement in patients affected by systemic lupus erythematosus: application of the swollen to tender joint count ratio , Reumatismo: Vol. 67 No. 2 (2015)
- M. Rossini, G. D'Avola, M. Muratore, N. Malavolta, F. Silveri, G. Bianchi, B. Frediani, G. Minisola, M. L. Sorgi, M. Varenna, R. Foti, G. Tartarelli, G. Orsolini, S. Adami, Regional differences of vitamin D deficiency in rheumatoid arthritis patients in Italy , Reumatismo: Vol. 65 No. 3 (2013)
- L. Iaccarino, A. Ghirardello, M. Zen, D. Villalta, A. Tincani, L. Punzi, A. Doria, Polarization of TH2 response is decreased during pregnancy in systemic lupus erythematosus , Reumatismo: Vol. 64 No. 5 (2012)
- A. Bontadi, A. Ruffatti, S Giannini, E. Falcinelli, M. Tonello, A. Hoxha, P. Gresele, L. Punzi, In vitro effect of anti-β2 glycoprotein I antibodies on P-selectin expression, a marker of platelet activation , Reumatismo: Vol. 64 No. 1 (2012)
- F. Atzeni, L. Boccassini, M. Di Franco, A. Alciati, A. Marsico, M. Cazzola, G. Cassisi, P. Sarzi-Puttini, Chronic widespread pain in spondyloarthritis , Reumatismo: Vol. 66 No. 1 (2014)
- S. Stisi, P. Sarzi-Puttini, M. Benucci, G. Biasi, S. Bellissimo, R. Talotta, F. Atzeni, RETRACTED - Pain in systemic sclerosis , Reumatismo: Vol. 66 No. 1 (2014)
- M. Lorenzin, A. Ortolan, P. Frallonardo, S. Vio, C. Lacognata, F. Oliviero, L. Punzi, R. Ramonda, Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study , Reumatismo: Vol. 68 No. 2 (2016)
- I. Bertoldi, L. Cantarini, G. Filippou, B. Frediani, Paget’s disease , Reumatismo: Vol. 66 No. 2 (2014)
You may also start an advanced similarity search for this article.
