https://doi.org/10.4081/reumatismo.2024.1692
Diffuse idiopathic skeletal hyperostosis is associated with greater complexity of coronary artery disease burden on coronary angiography
Submitted: 7 December 2023
Accepted: 12 May 2024
Published: 1 October 2024
Accepted: 12 May 2024
Abstract Views: 569
PDF: 74
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Objective. Diffuse idiopathic skeletal hyperostosis (DISH) is a common disorder characterized by ossification of tendons and ligaments. DISH has been largely associated with an increased risk of metabolic syndrome and type 2 diabetes. The objective of the present study is to investigate the role of DISH on the risk of coronary artery disease (CAD).
Methods. We conducted an observational cross-sectional study of patients without a history of rheumatic musculoskeletal diseases who underwent coronary angiography between March 2016 and April 2021. The SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery (SYNTAX) score was calculated based on coronary angiography images. DISH diagnosis was based on standard X-ray images and computed tomography scans (Resnick criteria). Demographic and clinical characteristics were retrieved from electronic medical records. Multinomial and binary logistic regression models were employed to determine the association between SYNTAX score (dependent variable) and DISH (independent variable).
Results. The study included 187 patients, 82.9% of whom were men, with valid radiological imaging. 83 (44.4%) patients had a confirmed radiological diagnosis of DISH. Diagnosis of DISH was associated with a higher SYNTAX score [adjusted odds ratio (aOR) 34.1, 95% confidence interval (CI) 1.41-79.2 p=0.049], independently from traditional cardiovascular risk factors. In patients aged <70 years, DISH was associated with a 7-fold higher risk of belonging to the highest category of SYNTAX (≥34), compared to non-DISH (aOR 7.23, 95% CI 1.08-48.4; p=0.041). The extension of vertebral calcification was significantly associated with SYNTAX score (r2 0.378, p<0.0001).
Conclusions. DISH diagnosis is common in patients at high risk of cardiovascular disease or with definitive CAD. DISH was independently associated with higher CAD complexity.
Liang H, Liu G, Lu S, Chen S, Jiang D, Shi H, et al. Epidemiology of ossification of the spinal ligaments and associated factors in the Chinese population: a cross-sectional study of 2000 consecutive individuals. BMC Musculoskelet Disord 2019; 20: 253.
DOI: https://doi.org/10.1186/s12891-019-2569-1
Fassio A, Adami G, Idolazzi L, Giollo A, Viapiana O, Bosco E, et al. Diffuse idiopathic skeletal hyperostosis (DISH) in type 2 diabetes: a new imaging possibility and a new biomarker. Calcif Tissue Int 2021; 108: 231-9.
DOI: https://doi.org/10.1007/s00223-020-00768-2
Guiot A, Estublier C, Gaude M, Szulc P, Chapurlat R. Relationship between diffuse idiopathic skeletal hyperostosis and fragility vertebral fracture: a prospective study in older men. Rheumatology 2021; 60: 2197-205.
DOI: https://doi.org/10.1093/rheumatology/keaa517
Mader R, Verlaan JJ, Buskila D. Diffuse idiopathic skeletal hyperostosis: clinical features and pathogenic mechanisms. Nat Rev Rheumatol 2013; 9: 741-50.
DOI: https://doi.org/10.1038/nrrheum.2013.165
Resnick D, Niwayama G. Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology 1976; 119: 559-68.
DOI: https://doi.org/10.1148/119.3.559
Oudkerk SF, Mohamed Hoesein FAA, PThM Mali W, Öner FC, Verlaan JJ, de Jong PA, et al. Subjects with diffuse idiopathic skeletal hyperostosis have an increased burden of coronary artery disease: an evaluation in the COPDGene cohort. Atherosclerosis 2019; 287: 24-9.
DOI: https://doi.org/10.1016/j.atherosclerosis.2019.05.030
Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, et al. 2018 ESC/EACTS guidelines on myocardial revascularization. Eur Heart J 2019; 40: 87-165.
DOI: https://doi.org/10.1093/eurheartj/ehy855
Morice MC, Serruys PW, Kappetein AP, Feldman TE, Ståhle E, Colombo A, et al. Five-year outcomes in patients with left main disease treated with either percutaneous coronary intervention or coronary artery bypass grafting in the synergy between percutaneous coronary intervention with taxus and cardiac surgery trial. Circulation 2014; 129: 2388-94.
DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.006689
Serruys PW, Onuma Y, Garg S, Sarno G, van den Brand M, Kappetein AP, et al. Assessment of the SYNTAX score in the Syntax study. EuroIntervention 2009; 5: 50-6.
DOI: https://doi.org/10.4244/EIJV5I1A9
Chichareon P, Onuma Y, van Klaveren D, Modolo R, Kogame N, Takahashi K, et al. Validation of the updated logistic clinical SYNTAX score for all-cause mortality in the GLOBAL LEADERS trial. EuroIntervention 2019; 15: e539-46.
DOI: https://doi.org/10.4244/EIJ-D-19-00184
Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention 2005; 1: 219-27.
Xu B, Généreux P, Yang Y, Leon MB, Xu L, Qiao S, et al. Validation and comparison of the long-term prognostic capability of the SYNTAX score-II among 1,528 consecutive patients who underwent left main percutaneous coronary intervention. JACC Cardiovasc Interv 2014; 7: 1128-37.
DOI: https://doi.org/10.1016/j.jcin.2014.05.018
Levine GN, Bates ER, Bittl JA, Brindis RG, Fihn SD, Fleisher LA, et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines: an update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention, 2011 ACCF/AHA guideline for coronary artery bypass graft surgery, 2012 ACC/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease, 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction, 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes, and 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery. Circulation 2016; 134: e123-55.
DOI: https://doi.org/10.1161/CIR.0000000000000404
Dan Lantsman C, Brodov Y, Matetzky S, Beigel R, Lidar M, Eshed I, et al. No correlation between diffuse idiopathic skeletal hyperostosis and coronary artery disease on computed tomography using two different scoring systems. Acta Radiol 2023; 64: 508-14.
DOI: https://doi.org/10.1177/02841851221090890
Berthelot JM, Le Goff B, Maugars Y. Pathogenesis of hyperostosis: a key role for mesenchymatous cells? Joint Bone Spine 2013; 80: 592-6.
DOI: https://doi.org/10.1016/j.jbspin.2013.03.013
Xu L, Qian Z, Wang S, Wang R, Pu X, Yang B, et al. Galectin-3 enhances osteogenic differentiation of precursor cells from patients with diffuse idiopathic skeletal hyperostosis via Wnt/β-catenin signaling. J Bone Miner Res 2022; 37: 724-39.
DOI: https://doi.org/10.1002/jbmr.4508
Chiang HY, Chu PH, Chen SC, Lee TH. MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling. Commun Biol 2022; 5: 364.
DOI: https://doi.org/10.1038/s42003-022-03313-z
Gonçalves I, Oduor L, Matthes F, Rakem N, Meryn J, Skenteris NT, et al. Osteomodulin gene expression is associated with plaque calcification, stability, and fewer cardiovascular events in the CPIP cohort. Stroke 2022; 53: e79-84.
DOI: https://doi.org/10.1161/STROKEAHA.121.037223
Niu CC, Lin SS, Yuan LJ, Chen LH, Yang CY, Chung AN, et al. Correlation of blood bone turnover biomarkers and Wnt signaling antagonists with AS, DISH, OPLL, and OYL. BMC Musculoskelet Disord 2017; 18: 61.
DOI: https://doi.org/10.1186/s12891-017-1425-4
Golledge J, Thanigaimani S. Role of sclerostin in cardiovascular disease. Arterioscler Thromb Vasc Biol 2022; 42: e187-202.
DOI: https://doi.org/10.1161/ATVBAHA.122.317635
He J, Pan M, Xu M, Chen R. Circulating miRNA-29b and sclerostin levels correlate with coronary artery calcification and cardiovascular events in maintenance hemodialysis patients. Cardiol Res Pract 2021; 2021: 9208634.
DOI: https://doi.org/10.1155/2021/9208634
Shui X, Dong R, Wu Z, Chen Z, Wen Z, Tang L, et al. Association of serum sclerostin and osteoprotegerin levels with the presence, severity and prognosis in patients with acute myocardial infarction. BMC Cardiovasc Disord 2022; 22: 213.
DOI: https://doi.org/10.1186/s12872-022-02654-1
Zincarelli C, Iervolino S, Di Minno MND, Miniero E, Rengo C, Di Gioia L, et al. Diffuse idiopathic skeletal hyperostosis prevalence in subjects with severe atherosclerotic cardiovascular diseases. Arthritis Care Res 2012; 64: 1765-9.
DOI: https://doi.org/10.1002/acr.21742
How to Cite
Adami, G., Zanon, S., Fassio, A., Pesarini, G., Pighi, M., Scarsini, R., … Ribichini, F. (2024). Diffuse idiopathic skeletal hyperostosis is associated with greater complexity of coronary artery disease burden on coronary angiography. Reumatismo. https://doi.org/10.4081/reumatismo.2024.1692
Copyright (c) 2024 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- F. Atzeni, F. Salaffi, L. Bazzichi, R.H. Gracely, R. Carignola, R. Torta, R. Gorla, A. Marsico, F. Ceccherelli, M. Cazzola, D. Buskila, M. Spath, M. Di Franco, G. Biasi, G. Cassisi, S. Stisi, R. Casale, L. Altomonte, G. Arioli, A. Alciati, G. Leardini, F. Marinangeli, M.A. Giamberardino, P. Sarzi-Puttini, The evaluation of the fibromyalgia patients , Reumatismo: Vol. 60 No. s1 (2008)
- S. Adami, O. Viapiana, Pathophysiology of osteoarthritis: perspectives , Reumatismo: Vol. 53 No. 1 (2001)
- E. Marcucci, E. Bartoloni, A. Alunno, M.C. Leone, G. Cafaro, F. Luccioli, V. Valentini, E. Valentini, G.M.C. La Paglia, A.F. Bonifacio, R. Gerli, Extra-articular rheumatoid arthritis , Reumatismo: Vol. 70 No. 4 (2018)
- Irene Pontikaki, Valeria Gerloni, Maurizio Gattinara, Alfredomaria Lurati, Alessandra Salmaso, Gabriele De Marco, Barbara Teruzzi, Elisabetta Valcamonica, Flavio Fantini, Side effects of anti-TNFa therapy in juvenile idiopathic arthritis , Reumatismo: Vol. 58 No. 1 (2006)
- G. Brambilla, A. Brucato, Y. Adler, M. Bosetti, P. Coppini, A. Caforio, D. Spodick, B. Canesi, Recurrent acute idiopathic pericarditis: rheumatologic therapy, autoantibodies and long term outcome , Reumatismo: Vol. 59 No. 1 (2007)
- S. Vettori, G. Cuomo, G. Abignano, M. Iudici, G. Valentini, Survival and death causes in 251 systemic sclerosis patients from a single Italian center , Reumatismo: Vol. 62 No. 3 (2010)
- N. Belfeki, N. Louarn, I. Chouchane, A. Abbadi, S. Diamantis, The place of 18F FDG PET/CT in the management of patients with eosinophilic fasciitis: a case report , Reumatismo: Vol. 72 No. 4 (2020)
- B. Seriolo, A. Sulli, B. Burroni, M. Cutolo, Rheumatoid arthritis and atherosclerosis , Reumatismo: Vol. 55 No. 3 (2003)
- A. Corrado, F.P. Cantatore, The bisphosponates: chemical characteristics, skeletal biological effects and extra-skeletal effects , Reumatismo: Vol. 57 No. 3 (2005)
- M. Rossini, S. Adami, F. Bertoldo, D. Diacinti, D. Gatti, S. Giannini, A. Giusti, N. Malavolta, S. Minisola, G. Osella, M. Pedrazzoni, L. Sinigaglia, O. Viapiana, G. C. Isaia, Guidelines for the diagnosis, prevention and management of osteoporosis , Reumatismo: Vol. 68 No. 1 (2016)
<< < 22 23 24 25 26 27 28 29 30 31 > >>
You may also start an advanced similarity search for this article.
