https://doi.org/10.4081/reumatismo.2024.1647

Visceral muscle dysmotility syndrome in systemic lupus erythematosus: which is the role of 18 fluorodeoxyglucose-positron emission tomography-computed tomography? A clinical case and literature review

Early Access
Submitted: 13 September 2023
Accepted: 1 May 2024
Published: 24 September 2024
Systemic lupus erythematosus, visceral muscle dysmotility syndrome, generalized megaviscerous of lupus, 18 fluorodeoxyglucose-positron emission tomography-computed tomography
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Authors

S. Scriffignano
https://orcid.org/0000-0001-5774-9643
Academic Rheumatology Unit, Department of Medicine and Health Science “Vincenzo Tiberio,” University of Molise, Campobasso, Italy.
F.M. Perrotta
https://orcid.org/0000-0003-3771-5205
Academic Rheumatology Unit, Department of Medicine and Health Science “Vincenzo Tiberio,” University of Molise, Campobasso, Italy.
M. Ricci
https://orcid.org/0000-0002-9277-6337
Nuclear Medicine Unit, Ospedale Cardarelli, Campobasso, Italy.
B. Carabellese
Nuclear Medicine Unit, Ospedale Cardarelli, Campobasso, Italy.
E. Lubrano
enniolubrano@hotmail.com
https://orcid.org/0000-0001-6189-5328
Academic Rheumatology Unit, Department of Medicine and Health Science “Vincenzo Tiberio,” University of Molise, Campobasso, Italy.

Visceral muscle dysmotility syndrome (VMDS) is a rare syndrome, described in the systemic lupus erythematosus (SLE) clinical course. It is characterized by diffuse thickened intestinal wall and gastrointestinal-genitourinary-hepatobiliary hollow viscera dilatation and dysmotility. Due to the rarity and the heterogeneity of the clinical characteristics of this syndrome, it is not entirely clear which is the best diagnostic imaging technique for the diagnosis and/or follow-up, even if, in all the described cases, computed tomography (CT) was generally used to study visceral involvement. However, there are no cases describing the visceral metabolic activity by 18 fluorodeoxyglucose (18FDG)-positron emission tomography-CT (18FDG-PET-CT). Here, we reported the first clinical case of VMDS studied by 18FDG-PET-CT, characterizing the metabolic activity of this rare syndrome during SLE flare. We found a high intestinal metabolic burden, hyper-fixation in duodenum, and high hepatic metabolic activity. Moreover, we reviewed the literature on VMDS in SLE, focusing on imaging techniques in different anatomical sites (bowel, urinary tract, bile ducts), patients' symptoms, and treatment.

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How to Cite

Scriffignano, S., Perrotta, F., Ricci, M., Carabellese, B., & Lubrano , E. (2024). Visceral muscle dysmotility syndrome in systemic lupus erythematosus: which is the role of 18 fluorodeoxyglucose-positron emission tomography-computed tomography? A clinical case and literature review. Reumatismo. https://doi.org/10.4081/reumatismo.2024.1647
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