https://doi.org/10.4081/reumatismo.2024.1638

Disease activity assessment for juvenile idiopathic arthritis in transitional care

Vol. 76 No. 2 (2024)
Submitted: 22 August 2023
Accepted: 24 March 2024
Published: 24 June 2024
Transition, juvenile idiopathic arthritis, disease activity score, JADAS, SDAI
Abstract Views: 1507
PDF: 478
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Authors

F. La Torre
latorre_francesco@virgilio.it
https://orcid.org/0000-0002-5235-2900
Department of Pediatrics, Pediatric Rheumatology Center, Giovanni XXIII Pediatric Hospital, University of Bari, Italy.
C. Coppola
https://orcid.org/0009-0009-7843-4400
Department of Interdisciplinary Medicine, University of Bari, Italy.
M.G. Anelli
https://orcid.org/0000-0002-1018-1218
Rheumatology Unit, Department of Emergency and Organs Transplantation, University of Bari, Italy.
F. Cacciapaglia
Rheumatology Unit, Department of Emergency and Organs Transplantation, University of Bari, Italy.
G. Lopalco
Rheumatology Unit, Department of Emergency and Organs Transplantation, University of Bari, Italy.
F. Cardinale
Department of Pediatrics, Pediatric Rheumatology Center, Giovanni XXIII Pediatric Hospital, University of Bari, Italy.
F. Iannone
https://orcid.org/0000-0003-0474-5344
Rheumatology Unit, Department of Emergency and Organs Transplantation, University of Bari, Italy.

Objective. The indices to measure disease activity of chronic arthritis in adulthood and childhood are different. Therefore, assessing the status of the disease in young patients with juvenile idiopathic arthritis (JIA) can be tricky, especially when the transition to adult care is ongoing. The aim of our study was to assess the level of correlation between adult and juvenile scores in the measurement of disease activity in JIA patients during transitional care.

Methods. We estimated the disease activity by using the Juvenile Arthritis Disease Activity Score 71 (JADAS71), clinical JADAS, adult Disease Activity Score (DAS28), Simplified Disease Activity Index (SDAI), and Clinical Disease Activity Index (CDAI) in JIA patients in transitional care. We enrolled patients older than 16 years at the time of the first transition visit, and disease activity was assessed at baseline and 12 months. Regression analyses were carried out to estimate the level of agreement among the different indices.

Results. We recruited 26 patients with JIA; 11 patients were polyarticular (42.3%) and 15 patients were oligoarticular (53.1%). The mean age at diagnosis was 7.7±3.9 years and the age at the first evaluation was 20.9±3.7 years. The correlation between JADAS71 and DAS28 was r2=0.69, r2=0.86 between JADAS71 and SDAI, and r2=0.81 between JADAS71 and CDAI.

Conclusions. SDAI and JADAS71 showed the best correlation, but a few patients were not captured at the same level of disease activity. New prospective studies with a larger number of patients will be needed in this field.

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Google Scholar
Europe PMC
Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet 2007; 369: 767-78. DOI: https://doi.org/10.1016/S0140-6736(07)60363-8
Consolaro A, Giancane G, Schiappapietra B, Davì S, Calandra S, Lanni S, et al. Clinical outcome measures in juvenile idiopathic arthritis. Pediatr Rheumatol Online J 2016; 14: 23. DOI: https://doi.org/10.1186/s12969-016-0085-5
Stringer E, Scott R, Mosher D, MacNeill I, Huber AM, Ramsey S, et al. Evaluation of a Rheumatology Transition Clinic. Pediatr Rheumatol Online J 2015; 13: 22. DOI: https://doi.org/10.1186/s12969-015-0016-x
van Pelt PA, Kruize AA, Goren SS, van der Net J, Uiterwaal C, Kuis W, et al. Transition of rheumatologic care, from teenager to adult: which health assessment questionnaire can be best used? Clin Exp Rheumatol 2010; 28: 281-6.
Conti F, Pontikaki I, D’Andrea M, Ravelli A, De Benedetti F. Patients with juvenile idiopathic arthritis become adults: the role of transitional care. Clin Exp Rheumatol 2018; 36: 1086-94.
Ravelli A, Sinigaglia L, Cimaz R, Alessio M, Breda L, Cattalini M, et al. Transitional care of young people with juvenile idiopathic arthritis in Italy: results of a Delphi consensus survey. Clin Exp Rheumatol 2019; 37: 1084-91.
van Pelt PA, Dolhain RJEM, Kruize AA, Ammerlaan JJW, Hazes JW, Bijlsma JWJ, et al. Disease activity and dropout in young persons with juvenile idiopathic arthritis in transition of care: a longitudinal observational study. Clin Exp Rheumatol 2018; 36: 163-8.
Hersh AO, Pang S, Curran ML, Milojevic DS, Von Scheven E. The challenges of transferring chronic illness patients to adult care: reflections from pediatric and adult rheumatology at a US academic center. Pediatr Rheumatol Online J 2009; 7: 13. DOI: https://doi.org/10.1186/1546-0096-7-13
Consolaro A, Ruperto N, Bazso A, Pistorio A, Magni-Manzoni S, Filocamo G, et al. Development and validation of a composite disease activity score for juvenile idiopathic arthritis. Arthritis Rheum 2009; 61: 658-66. DOI: https://doi.org/10.1002/art.24516
Smolen JS, Breedveld FC, Schiff MH, Kalden JR, Emery P, Eberl G, et al. A simplified disease activity index for rheumatoid arthritis for use in clinical practice. Rheumatology (Oxford) 2003; 42: 244-57. DOI: https://doi.org/10.1093/rheumatology/keg072
Aletaha D, Nell VP, Stamm T, Uffmann M, Pflugbeil S, Machold K, et al. Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score. Arthritis Res Ther 2005; 7: R796-806. DOI: https://doi.org/10.1186/ar1740
Consolaro A, Bracciolini G, Ruperto N, Pistorio A, Magni-Manzoni S, Malattia C, et al. Remission, minimal disease activity and acceptable symptom state in juvenile idiopathic arthritis. Arthritis Rheum 2012; 64: 2366-74. DOI: https://doi.org/10.1002/art.34373
Consolaro A, Ruperto N, Bracciolini G, Frisina A, Gallo MC, Pistorio A, et al. Defining criteria for high disease activity in juvenile idiopathic arthritis based on the juvenile arthritis disease activity score. Ann Rheum Dis 2014; 73: 1380-3. DOI: https://doi.org/10.1136/annrheumdis-2013-204186
Wu Q, Chaplin H, Ambrose N, Sen D, Leandro MJ, Wing C, et al. Juvenile arthritis disease activity score is a better reflector of active disease than the disease activity score 28 in adults with polyarticular juvenile idiopathic arthritis. Ann Rheum Dis 2016; 75: 635-6. DOI: https://doi.org/10.1136/annrheumdis-2015-208462

How to Cite

La Torre, F., Coppola, C., Anelli, M., Cacciapaglia, F., Lopalco, G., Cardinale, F., & Iannone, F. (2024). Disease activity assessment for juvenile idiopathic arthritis in transitional care. Reumatismo, 76(2). https://doi.org/10.4081/reumatismo.2024.1638
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