https://doi.org/10.4081/reumatismo.2023.1566
Acute severe gouty arthritis secondary to isotretinoin toxicity in a young male: a case report
Submitted: 11 February 2023
Accepted: 3 August 2023
Published: 18 September 2023
Accepted: 3 August 2023
Abstract Views: 1642
PDF: 526
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Acute gouty arthritis is a recognized complication of hyperuricemia and one of the most common forms of inflammatory arthritis in adults. Drug-induced hyperuricemia is increasingly prevalent in clinical practice. Diuretics, antitubercular medications, and immunosuppressants are the common drugs associated with hyperuricemia. Oral isotretinoin is the drug of choice for different forms of severe acne and is rarely associated with hyperuricemia. We present the case of a 30-year-old male with severe acne vulgaris who was prescribed isotretinoin and later presented with acute gout. The patient developed hyperuricemia and swelling of the right first metatarsophalangeal joint within two months of isotretinoin commencement. There was a second episode of similar joint swelling three months later, parallel to the isotretinoin rechallenge. The dose of isotretinoin was reduced with the addition of febuxostat. The patient did not develop further episodes and remained symptom-free without urate-lowering therapy.
Ragab G, Elshahaly M, Bardin T. Gout: an old disease in new perspective - a review. J Adv Res 2017; 8: 495-511.
DOI: https://doi.org/10.1016/j.jare.2017.04.008
Dalbeth N., Merriman T.R., Stamp L.K. Gout. Lancet 2016; 388: 2039-52.
DOI: https://doi.org/10.1016/S0140-6736(16)00346-9
Ben Salem C, Slim R, Fathallah N, Hmouda H. Drug-induced hyperuricaemia and gout. Rheumatology 2017; 56: 679-88.
DOI: https://doi.org/10.1093/rheumatology/kew293
Pile HD, Sadiq NM. Isotretinoin. Treasure Island (FL): StatPearls Publishing; 2022.
Karaosmanoğlu N, Mülkoğlu C. Analysis of musculoskeletal side effects of oral isotretinoin treatment: a cross-sectional study. BMC Musculoskelet Disord 2020; 21: 631.
DOI: https://doi.org/10.1186/s12891-020-03656-w
Solak B, Erdem T, Solak Y. Isotretinoin use for acne vulgaris is associated with increased serum uric acid levels. J Dermatolog Treat 2017; 28: 82-5.
DOI: https://doi.org/10.1080/09546634.2016.1178374
Choi WJ, Ford ES, Curhan G, Rankin JI, Choi HK. Independent association of serum retinol and β-carotene levels with hyperuricemia: a national population study. Arthritis Care Res 2012; 64: 389-96.
DOI: https://doi.org/10.1002/acr.20692
Vanhooteghem O, Andre J, Pochet JM, Demaubeuge J, Song M. Occurrence of gouty tophi following acitretin therapy. Clin Exp Dermatol 1998; 23: 274-6.
DOI: https://doi.org/10.1046/j.1365-2230.1998.00362.x
Neogi T, Jansen TL, Dalbeth N, Fransen J, Schumacher HR, Berendsen D, et al. 2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheumatol 2015; 67: 2557-68.
DOI: https://doi.org/10.1002/art.39254
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-45.
DOI: https://doi.org/10.1038/clpt.1981.154
Mandal A.K., Mount D.B. The molecular physiology of uric acid homeostasis. Annu Rev Physiol 2015; 77: 323-45.
DOI: https://doi.org/10.1146/annurev-physiol-021113-170343
Taibi G, Nicotra CMA. Xanthine oxidase catalyzes the oxidation of retinol. J Enzyme Inhib Med Chem 2007; 22: 471-6.
DOI: https://doi.org/10.1080/14756360701408739
Li Y, Liu X, Luo Y. Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study. BMC Endocr Disord 2022; 22: 48.
DOI: https://doi.org/10.1186/s12902-022-00966-z
How to Cite
Meena, D., Kumar, D., & Bohra, G. (2023). Acute severe gouty arthritis secondary to isotretinoin toxicity in a young male: a case report. Reumatismo, 75(3). https://doi.org/10.4081/reumatismo.2023.1566
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