https://doi.org/10.4081/reumatismo.2023.1566
Acute severe gouty arthritis secondary to isotretinoin toxicity in a young male: a case report
Submitted: 11 February 2023
Accepted: 3 August 2023
Published: 18 September 2023
Accepted: 3 August 2023
Abstract Views: 1644
PDF: 526
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Acute gouty arthritis is a recognized complication of hyperuricemia and one of the most common forms of inflammatory arthritis in adults. Drug-induced hyperuricemia is increasingly prevalent in clinical practice. Diuretics, antitubercular medications, and immunosuppressants are the common drugs associated with hyperuricemia. Oral isotretinoin is the drug of choice for different forms of severe acne and is rarely associated with hyperuricemia. We present the case of a 30-year-old male with severe acne vulgaris who was prescribed isotretinoin and later presented with acute gout. The patient developed hyperuricemia and swelling of the right first metatarsophalangeal joint within two months of isotretinoin commencement. There was a second episode of similar joint swelling three months later, parallel to the isotretinoin rechallenge. The dose of isotretinoin was reduced with the addition of febuxostat. The patient did not develop further episodes and remained symptom-free without urate-lowering therapy.
Ragab G, Elshahaly M, Bardin T. Gout: an old disease in new perspective - a review. J Adv Res 2017; 8: 495-511.
DOI: https://doi.org/10.1016/j.jare.2017.04.008
Dalbeth N., Merriman T.R., Stamp L.K. Gout. Lancet 2016; 388: 2039-52.
DOI: https://doi.org/10.1016/S0140-6736(16)00346-9
Ben Salem C, Slim R, Fathallah N, Hmouda H. Drug-induced hyperuricaemia and gout. Rheumatology 2017; 56: 679-88.
DOI: https://doi.org/10.1093/rheumatology/kew293
Pile HD, Sadiq NM. Isotretinoin. Treasure Island (FL): StatPearls Publishing; 2022.
Karaosmanoğlu N, Mülkoğlu C. Analysis of musculoskeletal side effects of oral isotretinoin treatment: a cross-sectional study. BMC Musculoskelet Disord 2020; 21: 631.
DOI: https://doi.org/10.1186/s12891-020-03656-w
Solak B, Erdem T, Solak Y. Isotretinoin use for acne vulgaris is associated with increased serum uric acid levels. J Dermatolog Treat 2017; 28: 82-5.
DOI: https://doi.org/10.1080/09546634.2016.1178374
Choi WJ, Ford ES, Curhan G, Rankin JI, Choi HK. Independent association of serum retinol and β-carotene levels with hyperuricemia: a national population study. Arthritis Care Res 2012; 64: 389-96.
DOI: https://doi.org/10.1002/acr.20692
Vanhooteghem O, Andre J, Pochet JM, Demaubeuge J, Song M. Occurrence of gouty tophi following acitretin therapy. Clin Exp Dermatol 1998; 23: 274-6.
DOI: https://doi.org/10.1046/j.1365-2230.1998.00362.x
Neogi T, Jansen TL, Dalbeth N, Fransen J, Schumacher HR, Berendsen D, et al. 2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheumatol 2015; 67: 2557-68.
DOI: https://doi.org/10.1002/art.39254
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-45.
DOI: https://doi.org/10.1038/clpt.1981.154
Mandal A.K., Mount D.B. The molecular physiology of uric acid homeostasis. Annu Rev Physiol 2015; 77: 323-45.
DOI: https://doi.org/10.1146/annurev-physiol-021113-170343
Taibi G, Nicotra CMA. Xanthine oxidase catalyzes the oxidation of retinol. J Enzyme Inhib Med Chem 2007; 22: 471-6.
DOI: https://doi.org/10.1080/14756360701408739
Li Y, Liu X, Luo Y. Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study. BMC Endocr Disord 2022; 22: 48.
DOI: https://doi.org/10.1186/s12902-022-00966-z
How to Cite
Meena, D., Kumar, D., & Bohra, G. (2023). Acute severe gouty arthritis secondary to isotretinoin toxicity in a young male: a case report. Reumatismo, 75(3). https://doi.org/10.4081/reumatismo.2023.1566
Copyright (c) 2023 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- M. Carotti, E. Filippucci, F. Salaffi, Power Doppler sonography and ultrasound contrast agent in assessing rheumatoid synovitis , Reumatismo: Vol. 54 No. 4 (2002)
- A. Antonello, M. Rippa Bonati, A. D'Angelo, G. Gambaro, L. Calò, L. Bonfante, Gout and kidney during XVII and XIX centuries , Reumatismo: Vol. 54 No. 2 (2002)
- D. Mohamadzadeh, S. Assar, F. Farsad, Acquired hemophilia A treated with rituximab in a 62-year-old female with rheumatoid arthritis: a case-based review , Reumatismo: Vol. 75 No. 4 (2023)
- P. Grypiotis, A. Ruffatti, M. Tonello, C. Winzler, C. Radu, S. Zampieri, M. Favaro, A. Calligaro, S. Todesco, Clinical significance of fluoroscopic patterns specific for the mitotic spindle in patients with reumatic diseases , Reumatismo: Vol. 54 No. 3 (2002)
- B. Ruaro, S. Paolino, C. Pizzorni, M. Cutolo, A. Sulli, Assessment of treatment effects on digital ulcer and blood perfusion by laser speckle contrast analysis in a patient affected by systemic sclerosis , Reumatismo: Vol. 69 No. 3 (2017)
- M. Gutierrez, E. Filippucci, R. De Angelis, C. Bertolazzi, A. Becciolini, A. Ariani, W. Grassi, The ultrasound assessment of the psoriatic arthritis: from joint to skin , Reumatismo: Vol. 61 No. 4 (2009)
- C. Palazzi, I. Olivieri, C. Salvarani, E. D'Amico, G. Alleva, P. Vitullo, A. Petricca, Reactive arthritis: advances in diagnosis and treatment , Reumatismo: Vol. 54 No. 2 (2002)
- F.M. Mariani, A. Alunno, F. Carubbi, C. Ferri, A rare case of symptomatic creatine kinase elevation in a patient with rheumatoid arthritis treated with baricitinib , Reumatismo: Vol. 76 No. 2 (2024)
- M. Manara, M. Varenna, A clinical overview of bone marrow edema , Reumatismo: Vol. 66 No. 2 (2014)
- N. Ughi, R. Padoan, C. Crotti, S. Sciascia, G. Carrara, A. Zanetti, D. Rozza, S. Monti, D. Camellino, F. Muratore, G. Emmi, L. Quartuccio, S. Morbelli, K. El Aoufy, S. Tonolo, R. Caporali, S. De Vita, C. Salvarani, M.A. Cimmino, The Italian Society of Rheumatology clinical practice guidelines for the management of large vessel vasculitis , Reumatismo: Vol. 73 No. 4 (2021)
<< < 19 20 21 22 23 24 25 26 27 28 > >>
You may also start an advanced similarity search for this article.
