https://doi.org/10.4081/reumatismo.2023.1557
Can restless legs be a sign of something else? A case report of spondyloarthritis presenting with restless legs syndrome and a review of the literature
Submitted: 21 January 2023
Accepted: 30 August 2023
Published: 19 December 2023
Accepted: 30 August 2023
Abstract Views: 1490
PDF: 396
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Restless legs syndrome (RLS) is a chronic movement disorder characterized by an urge or need to move the limbs, usually associated with uncomfortable sensations in the legs and sleep disorders. In general, two clinical forms of RLS are described: primary and secondary. Although primary RLS has a familial component, the underlying mechanism is still not fully understood but seems to be related to abnormalities in the dopaminergic and glutamatergic pathways of the central nervous system. The secondary forms of the syndrome are associated with iron deficiency, renal failure, pregnancy, diabetes mellitus, peripheral neuropathy, and several rheumatologic disorders such as rheumatoid arthritis and Sjögren’s syndrome. In a few clinical trials, an increased frequency of RLS has been reported in patients with spondyloarthritis. In this report, a case of coexistence of spondyloarthritis and RLS is presented, showing satisfactory improvement with conservative treatment and additionally adding naproxen. Anemia of chronic disease occurring in rheumatic diseases, and associated iron deficiency may contribute to the development of RLS.
Guo S, Huang J, Jiang H, Han C, Li J, Xu X, et al. Restless legs syndrome: from pathophysiology to clinical diagnosis and management. Front Aging Neurosci 2017; 9: 171.
DOI: https://doi.org/10.3389/fnagi.2017.00171
Khan MA. Update on spondyloarthropathies. Ann Int Med 2002; 136: 896-907.
DOI: https://doi.org/10.7326/0003-4819-136-12-200206180-00011
Rudwaleit M. New approaches to diagnosis and classification of axial and peripheral spondyloarthritis. Curr Opin Rheumatol 2010; 22: 375-80.
DOI: https://doi.org/10.1097/BOR.0b013e32833ac5cc
Tekatas A, Pamuk ON. Increased frequency of restless leg syndrome in patients with ankylosing spondylitis. Int J Rheum Dis 2015; 18: 58-62.
DOI: https://doi.org/10.1111/1756-185X.12323
Demirci S, Demirci K, Doğru A, İnal EE, Koyuncuoğlu HR, Şahin M. Restless legs syndrome is associated with poor sleep quality of life in patients with ankylosing spondylitis: a questionnaire-based study. Acta Neurol Belg 2016; 116: 329-36.
DOI: https://doi.org/10.1007/s13760-015-0564-3
Yüksel GA, Kurtuluş D, Tireli H. Sleep quality and restless legs syndrome in patients with ankylosing spondylitis. Haydarpaşa Numune Med J 2019; 59: 78-83.
DOI: https://doi.org/10.14744/hnhj.2018.93723
Zontul S, Altay Z. Evaluation of the relationship between disorder parameters and sleeping quality in ankylosing spondylitis patients. KSU Med J 2021; 16: 311-5. [Article in Turkish].
DOI: https://doi.org/10.17517/ksutfd.803282
Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med 2014; 15: 860-73.
DOI: https://doi.org/10.1016/j.sleep.2014.03.025
Raychaudhuri SP, Deodhar A. The classification and diagnostic criteria of ankylosing spondylitis. J Autoimmun 2014; 48-49: 128-33.
DOI: https://doi.org/10.1016/j.jaut.2014.01.015
Hening WA, Caivano CK. Restless legs syndrome: a common disorder in patients with rheumatologic conditions. Semin Arthritis Rheum 2008; 38: 55-62.
DOI: https://doi.org/10.1016/j.semarthrit.2007.09.001
Gjevre JA, Gjevre RMT. Restless legs syndrome as a comorbidity in rheumatoid arthritis. Autoimmune Dis 2013; 2013: 352782.
DOI: https://doi.org/10.1155/2013/352782
Connor JR, Boyer PJ, Menzies SL, Dellinger B, Allen RP, Ondo WG, et al. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology 2003; 61: 304-9.
DOI: https://doi.org/10.1212/01.WNL.0000078887.16593.12
Weinstock LB, Walters AS, Paueksakon P. Restless legs syndrome - theoretical roles of inflammatory and immune mechanisms. Sleep Med Rev 2012; 16: 341-54.
DOI: https://doi.org/10.1016/j.smrv.2011.09.003
Gemignani F, Vitetta F, Brindani F, Contini M, Negrotti A. Painful polyneuropathy associated with restless legs syndrome. Clinical features and sensory profile. Sleep Med 2013; 14: 79-84.
DOI: https://doi.org/10.1016/j.sleep.2012.08.013
Wali S, Alsafadi S, Abaalkhail B, Ramadan I, Abulhamail B, Kousa M, et al. The association between vitamin D level and restless legs syndrome: a population-based-case-control study. J Clin Sleep Med 2018; 14: 557-64.
DOI: https://doi.org/10.5664/jcsm.7044
Urashima K, Ichinose K, Kondo H, Maeda T, Kawakami A, Ozawa H. The prevalence of insomnia and restless legs syndrome among Japanese outpatients with rheumatic disease: a cross-sectional study. PLoS One 2020; 15: e0230273.
DOI: https://doi.org/10.1371/journal.pone.0230273
How to Cite
Yılmaz, E. (2023). Can restless legs be a sign of something else? A case report of spondyloarthritis presenting with restless legs syndrome and a review of the literature. Reumatismo, 75(4). https://doi.org/10.4081/reumatismo.2023.1557
Copyright (c) 2023 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- F. Dall'Ara, I. Cavazzana, M. Frassi, M. Taraborelli, M. Fredi, F. Franceschini, L. Andreoli, M. Rossi, C. Cattaneo, A. Tincani, P. Airò, Macrophage activation syndrome in adult systemic lupus erythematosus: report of seven adult cases from a single Italian rheumatology center , Reumatismo: Vol. 70 No. 2 (2018)
- M. Lorenzin, A. Ortolan, P. Frallonardo, S. Vio, C. Lacognata, F. Oliviero, L. Punzi, R. Ramonda, Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study , Reumatismo: Vol. 68 No. 2 (2016)
- S. Bello, A. Rinaldi, S. Trabucco, L. Serafino, C. Bonali, G. Lapadula, Erasmus syndrome in a marble worker , Reumatismo: Vol. 67 No. 3 (2015)
- E. Shahi, C. Donati, M. Gattinara, I. Pontikaki, V. Gerloni, Primary Sjögren syndrome: report of a 10 years old girl with local edema and positivity of anti SS-A and anti SS-B autoantibodies , Reumatismo: Vol. 63 No. 2 (2011)
- P. Galozzi, O. Negm, E. Greco, N. Alkhattabi, A. Gava, P. Sfriso, L. Fairclough, I. Todd, P. Tighe, L. Punzi, Ex vivo and in vitro production of pro-inflammatory cytokines in Blau syndrome , Reumatismo: Vol. 66 No. 4 (2014)
- J.B. Pinto Carneiro, T. Pinto de Souza, T.M.L. Antunes de Oliveira, S.L. Euzébio Ribeiro, Coexistence of spondyloarthritis and joint hypermobility syndrome: rare or unknown association? , Reumatismo: Vol. 69 No. 3 (2017)
- M. Aouatef, B. Asma, H. Hajer, A. Charfeddine, B. Lamia, K. Taoufik, Work-related carpal tunnel syndrome treatment: a cross-sectional study among 106 patients , Reumatismo: Vol. 69 No. 2 (2017)
- C. Cosso, F. Rongioletti, G. Zampogna, D. Camellino, M. Cutolo, M. A. Cimmino, Seronegative spondyloarthritis and Darier’s disease: more than a casual association? , Reumatismo: Vol. 65 No. 2 (2013)
- F. Atzeni, L. Boccassini, M. Di Franco, A. Alciati, A. Marsico, M. Cazzola, G. Cassisi, P. Sarzi-Puttini, Chronic widespread pain in spondyloarthritis , Reumatismo: Vol. 66 No. 1 (2014)
- A. Zabotti, P. Della Siega, L. Picco, L. Quartuccio, M. Bassetti, S. De Vita, Gitelman syndrome disclosed by calcium pyrophosphate deposition disease: early diagnosis by ultrasonographic study , Reumatismo: Vol. 68 No. 1 (2016)
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.
