https://doi.org/10.4081/reumatismo.2023.1550
Oxidative stress may be a contributing factor in fibromyalgia patients’ pain mechanisms
Submitted: 8 January 2023
Accepted: 29 June 2023
Published: 18 September 2023
Accepted: 29 June 2023
Abstract Views: 1394
PDF: 471
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Objective. The pathophysiology of fibromyalgia (FM), a continuously painful syndrome with no known origin, has been related to mitochondrial dysfunction, oxidative stress, and inflammation. Recent studies have shown that FM may be associated with an oxidative balance disorder. The objective of this study was to measure the levels of oxidative stress in FM patients and try to understand the association between FM and free radicals.
Methods. This study was performed on 100 volunteers admitted to the University of Health Sciences, Sultan 2, Abdulhamid Han Health Application and Research Center Physical Therapy and Rehabilitation Clinic, including 50 healthy controls and 50 patients with FM. To analyze oxidative stress biomarkers, total oxidant status (TOS) and total antioxidant status (TAS) levels were measured. Total thiol (TT) and native thiol (NT) concentrations were measured to determine the relationship between thiol groups. Disulfide (DIS) and oxidative stress index (OSI) were calculated with mathematical formulas.
Results. While TOS and OSI levels were statistically higher in FM patients, TAS levels were significantly lower compared to the healthy control group (p<0.001). In comparison to the healthy control group, FM patients had considerably decreased TT and NT levels. DIS levels were significantly higher in FM patients than in controls (p<0.001).
Conclusions. Reactive oxygen species have several negative impacts on the human body. As a result of the measurements we analyzed, the relationship between FM and oxidative stress should be studied in terms of disease progression and may help improve the treatment process.
Neumeister MW, Neumeister EL. Fibromyalgia. Clin Plast Surg 2020; 47: 203-13.
DOI: https://doi.org/10.1016/j.cps.2019.12.007
Araújo FM, Melo DeSantana J. Physical therapy modalities for treating fibromyalgia. F1000Res 2019; 8: F1000 Faculty Rev-2030.
DOI: https://doi.org/10.12688/f1000research.17176.1
Kia S, Choy E. Update on treatment guideline in fibromyalgia syndrome with focus on pharmacology. Biomedicines 2017; 5: 20.
DOI: https://doi.org/10.3390/biomedicines5020020
McBeth J, Jones K. Epidemiology of chronic musculoskeletal pain. Best Pract Res Clin Rheumatol 2007; 21: 403-25.
DOI: https://doi.org/10.1016/j.berh.2007.03.003
Clauw DJ. Fibromyalgia: a clinical review. JAMA 2014; 311: 1547-55.
DOI: https://doi.org/10.1001/jama.2014.3266
Phillips K, Clauw DJ. Central pain mechanisms in the rheumatic diseases: future directions. Arthritis Rheum 2013; 65: 291-302.
DOI: https://doi.org/10.1002/art.37739
Wolfe F. Fibromyalgianess. Arthritis Rheum 2009; 61: 715-6.
DOI: https://doi.org/10.1002/art.24553
Wolfe F, Häuser W, Hassett AL, Katz RS, Walitt BT. The development of fibromyalgia - I: examination of rates and predictors in patients with rheumatoid arthritis (RA). Pain 2011; 152: 291-9.
DOI: https://doi.org/10.1016/j.pain.2010.09.027
Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q10 effect on clinical ımprovement. PLoS One 2012; 7: e35677.
DOI: https://doi.org/10.1371/journal.pone.0035677
Ward JPT. From physiological redox signalling to oxidant stress. Adv Exp Med Biol 2017; 967: 335-42.
DOI: https://doi.org/10.1007/978-3-319-63245-2_21
Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, Masini E, et al. A newly ıdentified role for superoxide in ınflammatory pain. J Pharmacol Exp Ther 2004; 309: 869-78.
DOI: https://doi.org/10.1124/jpet.103.064154
Chung CP, Titova D, Oeser A, Randels M, Avalos I, Milne GL, et al. Oxidative stress in fibromyalgia and its relationship to symptoms. Clin Rheumatol 2009; 28: 435-8.
DOI: https://doi.org/10.1007/s10067-008-1072-0
Wolfe F, Häuser W. Fibromyalgia diagnosis and diagnostic criteria. Ann Med 2011; 43: 495-502.
DOI: https://doi.org/10.3109/07853890.2011.595734
Wolfe F, Walitt BT, Rasker JJ, Katz RS, Häuser W. The use of polysymptomatic distress categories in the evaluation of fibromyalgia (FM) and FM severity. J Rheumatol 2015; 42: 1494-501.
DOI: https://doi.org/10.3899/jrheum.141519
Littlejohn GO, Guymer EK. In clinical practice, the term “central sensitivity score” ıs more useful than the term “polysymptomatic distress scale”: comment on the editorial by Wolfe. Arthritis Rheumatol 2015; 67: 2553.
DOI: https://doi.org/10.1002/art.39213
Wolfe F. New American college of rheumatology criteria for fibromyalgia: a twenty-year journey. Arthritis Care Res 2010; 62: 583-4.
DOI: https://doi.org/10.1002/acr.20156
Siracusa R, Di Paola R, Cuzzocrea S, Impellizzeri D. Fibromyalgia: pathogenesis, mechanisms, diagnosis and treatment options update. Int J Mol Sci 2021; 22: 3891.
DOI: https://doi.org/10.3390/ijms22083891
Staud R. Biology and therapy of fibromyalgia: pain in fibromyalgia syndrome. Arthritis Res Ther 2006; 8: 208.
DOI: https://doi.org/10.1186/ar1950
Hendrix J, Nijs J, Ickmans K, Godderis L, Ghosh M, Polli A. The ınterplay between oxidative stress, exercise, and pain in health and disease: potential role of autonomic regulation and epigenetic mechanisms. Antioxidants 2020; 9: 1166.
DOI: https://doi.org/10.3390/antiox9111166
Ito F, Sono Y, Ito T. Measurement and clinical significance of lipid peroxidation as a biomarker of oxidative stress: oxidative stress in diabetes, atherosclerosis, and chronic ınflammation. Antioxidants 2019; 8: 72.
DOI: https://doi.org/10.3390/antiox8030072
Brieger K, Schiavone S, Miller Jr, Krause KH. Reactive oxygen species: from health to disease. Swiss Med Wkly 2012; 142: w13659.
DOI: https://doi.org/10.4414/smw.2012.13659
Singh A, Kukreti R, Saso L, Kukreti S. Oxidative stress: a key modulator in neurodegenerative diseases. Molecules 2019; 24: 1583.
DOI: https://doi.org/10.3390/molecules24081583
Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005; 38: 1103-11.
DOI: https://doi.org/10.1016/j.clinbiochem.2005.08.008
Szarka A, Lőrincz T, Hajdinák P. Friend or foe: the relativity of (anti)oxidative agents and pathways. Int J Mol Sci 2022; 23: 5188.
DOI: https://doi.org/10.3390/ijms23095188
Bagis S, Tamer L, Sahin G, Bilgin R, Guler H, Ercan B, et al. Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? Rheumatol Int 2005; 25: 188-90.
DOI: https://doi.org/10.1007/s00296-003-0427-8
Çetinkaya FN, Koçak FA, Kurt EE, Güçlü K, Tuncay F, Şaş S, et al. The effects of balneotherapy on oxidant/antioxidant status in patients with fibromyalgia: an observational study. Arch Rheumatol 2020; 35: 506-14.
DOI: https://doi.org/10.46497/ArchRheumatol.2020.7857
Karatas G, Gunduz R, Haskul I, Ustun B, Neselioglu S, Karatas F, et al. Dynamic thiol and disulphide homoeostasis in fibromyalgia. Arch Med Sci 2020; 16: 597-602.
DOI: https://doi.org/10.5114/aoms.2019.87052
La Rubia M, Rus A, Molina F, Del Moral ML. Is fibromyalgia-related oxidative stress implicated in the decline of physical and mental health status? Clin Exp Rheumatol 2013; 31: S121-7.
Tuzcu A, Baykara RA, Alışık M, Omma A, Acet GK, Dogan E, et al. Alteration of thiol-disulfide homeostasis in fibromyalgia syndrome. Acta Medica 2019; 62: 12-8.
DOI: https://doi.org/10.14712/18059694.2019.40
Bazzini P, Wermuth CG. Substituent groups. In: Wermuth CG (ed). The practice of medicinal chemistry. Amsterdam, The Netherlands: Elsevier; 2008. pp. 319-57.
DOI: https://doi.org/10.1016/B978-0-12-417205-0.00013-4
Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell 2009; 139: 267-84.
DOI: https://doi.org/10.1016/j.cell.2009.09.028
Cortright DN, Krause JE, Broom DC. TRP channels and pain. Biochim Biophys Acta 2007; 1772: 978-88.
DOI: https://doi.org/10.1016/j.bbadis.2007.03.003
How to Cite
Beyaztas, H., Aktas, S., Guler, E., & Ata, E. (2023). Oxidative stress may be a contributing factor in fibromyalgia patients’ pain mechanisms. Reumatismo, 75(3). https://doi.org/10.4081/reumatismo.2023.1550
Copyright (c) 2023 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- S. Stisi, P. Sarzi-Puttini, M. Benucci, G. Biasi, S. Bellissimo, R. Talotta, F. Atzeni, RETRACTED - Pain in systemic sclerosis , Reumatismo: Vol. 66 No. 1 (2014)
- M. Radin, G. El Hasbani, A. Barinotti, D. Roccatello, I. Uthman, A. Taher, S. Sciascia, Quality of life measures in systemic lupus erythematosus: a systematic review , Reumatismo: Vol. 73 No. 4 (2021)
- R. Ramonda, P. Frallonardo, F. Oliviero, M.G. Lorenzin, A. Ortolan, A. Scanu, L. Punzi, Pain and microcrystalline arthritis , Reumatismo: Vol. 66 No. 1 (2014)
- S. Chandrashekara, V. Shobha, B.G. Dharmanand, R. Jois, S. Kumar, K.M. Mahendranath, V. Haridas, S. Prasad, Y. Singh, M.A. Daware, A. Swamy, R. Subramanian, S.A. Somashekar, A.M. Shanthappa, K.R. Anupama, Comorbidities and related factors in rheumatoid arthritis patients of south India- Karnataka Rheumatoid Arthritis Comorbidity (KRAC) study , Reumatismo: Vol. 69 No. 2 (2017)
- L. Punzi, M. Chia, S. Cipolletta, C. Dolcetti, P. Galozzi, O. Giovinazzi, S. Tonolo, R. Zava, F. Pazzaglia, The role of architectural design for rheumatic patients’ wellbeing: the point of view of Environmental Psychology , Reumatismo: Vol. 72 No. 1 (2020)
- F. Atzeni, L. Boccassini, M. Di Franco, A. Alciati, A. Marsico, M. Cazzola, G. Cassisi, P. Sarzi-Puttini, Chronic widespread pain in spondyloarthritis , Reumatismo: Vol. 66 No. 1 (2014)
- M. Varenna, F. Bertoldo, M. Di Monaco, A. Giusti, G. Martini, M. Rossini, On behalf of SIOMMMS, Endorsed by SIR, Safety profile of drugs used in the treatment of osteoporosis: a systematical review of the literature , Reumatismo: Vol. 65 No. 4 (2013)
- K.R. Ambrose, R.H. Gracely, J.M. Glass, Fibromyalgia dyscognition: concepts and issues , Reumatismo: Vol. 64 No. 4 (2012)
- M. Di Franco, M.P. Guzzo, F.R. Spinelli, F. Atzeni, P. Sarzi-Puttini, F. Conti, C. Iannuccelli, Pain and systemic lupus erythematosus , Reumatismo: Vol. 66 No. 1 (2014)
- F. Ginanneschi, G. Filippou, A. Adinolfi, V. Di Sabatino, B. Frediani, A. Rossi, Spasmophilia and entrapment nerve syndrome comorbidities in fibromyalgic patients: a possible neuromuscular pain generator , Reumatismo: Vol. 70 No. 4 (2018)
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.
