https://doi.org/10.4081/reumatismo.2023.1540
Adherence to treatment and associated factors in rheumatoid arthritis patients: a cross-sectional study from Iran
Submitted: 4 December 2022
Accepted: 27 March 2023
Published: 8 May 2023
Accepted: 27 March 2023
Abstract Views: 1214
PDF: 527
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The aim of this study is to evaluate adherence to treatment and its related risk factors among a sample of rheumatoid arthritis patients (RA) attending the rheumatology outpatient clinic of Kermanshah university of medical sciences. In this cross-sectional study, RA patients were asked to complete the Morisky questionnaire and 19-item compliance questionnaire for rheumatology (CQR). Patients were divided into two groups: adherent and non-adherent to treatment, based on the CQR questionnaire results. Demographic and clinical characteristics (age, sex, marital status, education level, economical condition, occupational status, place of residence, underlying diseases, type, and number of drugs) were compared between the two groups to investigate possible risk associations for poor adherence. 257 patients completed the questionnaires (mean age: 43.22, 80.2% female). 78.6% were married, 54.9% were housekeepers, 37.7% had tertiary education, 61.9% had moderate economic status, and 73.2% were residents of an urban area with a large population. Prednisolone was the most commonly used drug followed by non-steroidal anti-inflammatory drugs, sulfasalazine, hydroxychloroquine, and methotrexate. The mean score of the Morisky questionnaire was 5.528 (standard deviation=1.79). 105 patients (40.9%) were adherent to treatment based on the CQR questionnaire. High education level (college or university) was correlated with non-adherence to treatment [27 (25.71%) vs 70 (46.05%), p=0.004]. We concluded that the prevalence of non-adherence to treatment is 59.1% in rheumatoid arthritis patients in Kermanshah, Iran. Having a higher education level is a risk factor for poor treatment adherence. Other variables could not predict treatment adherence.
Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res. 2012; 64: 625-39.
DOI: https://doi.org/10.1002/acr.21641
Singh JA, Saag KG, Bridges Jr SL, Akl EA, Bannuru RR, Sullivan MC, et al. 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol. 2016; 68: 1-26.
DOI: https://doi.org/10.1002/art.39480
Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005; 353: 487-97.
DOI: https://doi.org/10.1056/NEJMra050100
Aletaha D, Smolen JS. Diagnosis and management of rheumatoid arthritis: a review. JAMA. 2018; 320: 1360-72.
DOI: https://doi.org/10.1001/jama.2018.13103
Kay J, Upchurch KS. ACR/EULAR 2010 rheumatoid arthritis classification criteria. Rheumatology. 2012; 51: vi5-9.
DOI: https://doi.org/10.1093/rheumatology/kes279
Balsa A, de Yébenes MJG, Carmona L. Multilevel factors predict medication adherence in rheumatoid arthritis: a 6-month cohort study. Ann Rheum Dis. 2022; 81: 327-34.
DOI: https://doi.org/10.1136/annrheumdis-2021-221163
Pombo-Suarez M, Fernandez JRM, Gomez-Reino JJ. Adherence to treatment in patients with rheumatoid arthritis from Spain. Patient Prefer Adherence. 2021; 15: 111-7.
DOI: https://doi.org/10.2147/PPA.S291983
Omair MA, Alshehri MM, Altokhais NA, Aljanobi GA, El Dessougi MI, AlHarthi A, et al. Exploring factors influencing medication compliance in saudi rheumatoid arthritis patients: a nationwide cross-sectional survey–results from the COPARA study. Patient Prefer Adherence. 2022; 16: 1105-14.
DOI: https://doi.org/10.2147/PPA.S363477
Kim D, Choi JY, Cho SK, Choi CB, Bang SY, Cha HS, et al. Prevalence and associated factors for non-adherence in patients with rheumatoid arthritis. J Rheum Dis. 2018; 25: 47-57.
DOI: https://doi.org/10.4078/jrd.2018.25.1.47
Salt E, Frazier S. Adherence to disease modifying anti-rheumatic drugs in rheumatoid arthritis patients: a narrative review of the literature. Orthop Nurs. 2010; 29: 260-75.
DOI: https://doi.org/10.1097/NOR.0b013e3181e5c2c9
Smolen JS, Gladman D, McNeil HP, Mease PJ, Sieper J, Hojnik M, et al. Predicting adherence to therapy in rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis: a large cross-sectional study. RMD Open. 2019; 5: e000585.
DOI: https://doi.org/10.1136/rmdopen-2017-000585
Michetti P, Weinman J, Mrowietz U, Smolen J, Peyrin-Biroulet L, Louis E, et al. Impact of treatment-related beliefs on medication adherence in immune-mediated inflammatory diseases: results of the global ALIGN study. Adv Ther. 2017; 34: 91-108.
DOI: https://doi.org/10.1007/s12325-016-0441-3
Turcu-Stiolica A, Subtirelu M-S, Ciurea PL, Stefan Cristian D, Bogdan M, Barbulescu AL, et al. The influence of socio-demographic factors, lifestyle and psychiatric indicators on adherence to treatment of patients with rheumatoid arthritis: a cross-sectional study. Medicina. 2020; 56: 178.
DOI: https://doi.org/10.3390/medicina56040178
van den Bemt BJF, van den Hoogen FHJ, Benraad B, Hekster YA, van Riel PLCM, van Lankveld W. Adherence rates and associations with nonadherence in patients with rheumatoid arthritis using disease modifying antirheumatic drugs. J Rheumatol. 2009; 36: 2164-70.
DOI: https://doi.org/10.3899/jrheum.081204
Moon SJ, Lee WY, Hwang JS, Hong YP, Morisky DE. Accuracy of a screening tool for medication adherence: a systematic review and meta-analysis of the Morisky medication adherence scale-8. PloS one. 2017; 12: e0187139.
DOI: https://doi.org/10.1371/journal.pone.0187139
Van Den Bemt BJ, Zwikker HE, Van Den Ende CH. Medication adherence in patients with rheumatoid arthritis: a critical appraisal of the existing literature. Expert Rev Clin Immunol. 2012; 8: 337-51.
DOI: https://doi.org/10.1586/eci.12.23
How to Cite
Mohamadzadeh, D., Assar, S., Pournazari, M., Soufivand, P., & Soleymani, M. (2023). Adherence to treatment and associated factors in rheumatoid arthritis patients: a cross-sectional study from Iran. Reumatismo, 75(1). https://doi.org/10.4081/reumatismo.2023.1540
Copyright (c) 2023 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- L. Fioravante da Silveira, A. Zago, D. Zanchet, D. Chemello, Macrophage activation syndrome in a patient with systemic lupus erythematosus undergoing cyclophosphamide treatment: a case report , Reumatismo: Vol. 75 No. 2 (2023)
- S. Manganelli, E. Selvi, M. Catenaccio, S. Cucini, R. De Stefano, E. Frati, M. Hammoud, R. Marcolongo, Diff-Quik® staining method for detection and identification of monosodium urate and calcium pyrophosphate crystals in synovial fluids , Reumatismo: Vol. 53 No. 4 (2001)
- P. Frallonardo, R. Ramonda, A. Lo Nigro, V. Modesti, C. Campana, L. Punzi, The natural history of ankylosing spondylitis in the 21st century , Reumatismo: Vol. 63 No. 1 (2011)
- V. Riccieri, A. Spadaro, E. Taccari, A. Zoppini, I. Markus, M. Sesztak, J. Ortutay, E. Koo, Immunohistochemical analysis of the expression of main adhesion molecules and tumor necrosis factors in the synovial membrane of psoriatic arthritis , Reumatismo: Vol. 55 No. 3 (2003)
- E. Marasco, M. Mussa, F. Motta, F. Bobbio-Pallavicini, R. Maserati, C. Montecucco, L. Bogliolo, Denosumab for the treatment of HIV-associated osteoporosis with fractures in a premenopausal woman , Reumatismo: Vol. 73 No. 1 (2021)
- N. Ughi, R. Padoan, C. Crotti, S. Sciascia, G. Carrara, A. Zanetti, D. Rozza, S. Monti, D. Camellino, F. Muratore, G. Emmi, L. Quartuccio, S. Morbelli, K. El Aoufy, S. Tonolo, R. Caporali, S. De Vita, C. Salvarani, M.A. Cimmino, The Italian Society of Rheumatology clinical practice guidelines for the management of large vessel vasculitis , Reumatismo: Vol. 73 No. 4 (2021)
- F.I. Gorial, N.I. Awadh, N.W. Shaheen, A. Dheyaa, Z.H. Ali, N. Wajdi, Emergence of acute promyelocytic leukemia in a patient with granulomatosis with polyangiitis during treatment with cyclophosphamide: a rare case report , Reumatismo: Vol. 75 No. 4 (2023)
- L. Punzi, B. Canesi, M. Carrabba, M.A. Cimmino, L. Frizziero, G. Lapadula, G. Arioli, M. Chevallard, F. Cozzi, C. Cricelli, A. Fioravanti, S. Giannini, F. Iannone, G. Leardini, A. Mannoni, R. Meliconi, V. Modena, L. Molfetta, V. Monteleone, T. Nava, L. Parente, E. Paresce, P. Patrignani, R. Ramonda, F. Salaffi, A. Spadaro, R. Marcolongo, Italian consensus on Eular 2003 recommendations for the treatment of knee osteoarthritis , Reumatismo: Vol. 56 No. 3 (2004)
- M. Ruggiero, A. Conforti, A. Culcasi, C. Mazzanti, G. Sibahi, N. Rani, S. Sartini, A focus on melorheostosis disease: a literature review and case report of femoral-acetabular impingement due to melorheostosis treated with surgical hip osteoplasty , Reumatismo: Vol. 76 No. 1 (2024)
- R. Ramonda, P. Zucchetta, C. Contessa, L. Punzi, The psoriatic great toe or the psoriatic onycho-pachydermo-periostitis of great toe (OP3gt) , Reumatismo: Vol. 56 No. 4 (2004)
<< < 37 38 39 40 41 42 43 44 45 46 > >>
You may also start an advanced similarity search for this article.
