https://doi.org/10.4081/reumatismo.2022.1508
Nailfold capillaroscopy in the rheumatological current clinical practice in Italy: results of a national survey
Submitted: 3 July 2022
Accepted: 27 September 2022
Published: 29 December 2022
Accepted: 27 September 2022
Abstract Views: 776
PDF: 318
Appendix: 753
Appendix: 753
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
This cross-sectional online study was designed by the study group on Capillaroscopy and Microcirculation in Rheumatic Diseases (CAP) of the Italian Society of Rheumatology (SIR) to provide an overview of the management of nailfold capillaroscopy in Italian rheumatology centers. Therefore, SIR distributed the survey to its members in July 2021, and each center’s physician with the most expertise in capillaroscopy completed the questionnaire. The survey was completed by 102 centers, with at least one representative from each Italian region. Ninety-three centers perform capillaroscopy, and 52 (56) conduct more than 200 investigations annually. Seventy-eight (84%) of respondents have more than five years of experience with the technique, and 75 centers (80.6%) have received certification from specific national or international training courses. In 85 centers, a videocapillaroscope with 200x magnification is employed (91.4%). The average waiting period for the examination is 2.4 months, and less than 3 months in 64 of the locations (68.8%). The study demonstrates that capillaroscopy is an integral part of both the diagnostic phase of Raynaud’s phenomenon and the monitoring of autoimmune connective tissue diseases (CTDs). However, the reporting methods and timing of patient followup are heterogeneous.
National Institute for Health and Care Excellence (NICE). The NICE Clinical Knowledge Summaries (CKS) site is only available to users in the UK, Crown Dependencies and British Overseas Territories; 2021. Available from. https://cks.nice.org.uk/topics/raynaudsphenomenon/management/management/
Cutolo M, Smith V. Detection of microvascular changes in systemic sclerosis and other rheumatic diseases. Nat Rev Rheumatol. 2021; 17:665-77.
DOI: https://doi.org/10.1038/s41584-021-00685-0
Pizzorni C, Cutolo M, Sulli A, et al. Long-term follow-up of nailfold videocapillaroscopic changes in dermatomyositis versus systemic sclerosis patients. Clin Rheumatol 2018; 37:2723-9.
DOI: https://doi.org/10.1007/s10067-018-4211-2
Bernero E, Sulli A, Ferrari G, et al. Prospective capillaroscopy-based study on transition fro primary to secondary Raynaud’s phenomenon: preliminary results. Reumatismo. 2013; 65:186-91.
DOI: https://doi.org/10.4081/reumatismo.2013.186
van den Hoogen F, Khanna D, Fransen J, et al. 2013 Classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. Ann Rheum Dis. 2013; 72: 1747-55.
DOI: https://doi.org/10.1136/annrheumdis-2013-204424
LeRoy EC, Medsger TA, Jr. Criteria for the classification of early systemic sclerosis. J Rheumatol. 2001; 28: 1573-6.
Bellando-Randone S, Del Galdo F, Lepri G, et al. Progression of patients with Raynaud’s phenomenon to systemic sclerosis: a five-year analysis of the European Scleroderma Trial and Research group multicenter, longitudinal registry study for Very Early Diagnosis of Systemic Sclerosis (VEDOSS). Lancet Rheumatol. 2021; 3: e834-e43.
DOI: https://doi.org/10.1016/S2665-9913(21)00244-7
Cutolo M. History of capillaroscopy. In: Cutolo M, editor. Atlas of capillaroscopy in rheumatic diseases. Milano: Elsevier; 2015.
DOI: https://doi.org/10.1007/978-1-4939-1526-2_12
Maricq HR, LeRoy EC. Patterns of finger capillary abnormalities in connective tissue disease by ‘wide-field’ microscopy. Arthritis Rheum. 1973; 16: 619-28.
DOI: https://doi.org/10.1002/art.1780160506
Cutolo M, Pizzorni C, Tuccio M, et al. Nailfold videocapillaroscopic patterns and serum autoantibodies in systemic sclerosis. Rheumatology (Oxford). 2004; 43: 719-26.
DOI: https://doi.org/10.1093/rheumatology/keh156
Cutolo M, Sulli A, Pizzorni C, Accardo S. Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis. J Rheumatol. 2000; 27: 155-60.
Ingegnoli F, Ughi N, Dinsdale G, et al. An international SUrvey on non-iNvaSive tecHniques to assess the mIcrocirculation in patients with RayNaud’s phEnomenon (SUNSHINE survey). Rheumatol Int. 2017; 37: 1879-90.
DOI: https://doi.org/10.1007/s00296-017-3808-0
Smith V, Herrick AL, Ingegnoli F, et al. Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud’s phenomenon and systemic sclerosis. Autoimmun Rev. 2020; 19: 102458.
DOI: https://doi.org/10.1016/j.autrev.2020.102458
Smith V, Vanhaecke A, Herrick AL, et al. Fast track algorithm: How to differentiate a ‘scleroderma pattern’ from a ‘non-scleroderma pattern’. Autoimmun Rev. 2019; 18: 102394.
DOI: https://doi.org/10.1016/j.autrev.2019.102394
Ingegnoli F, Herrick AL, Schioppo T, et al. Reporting items for capillaroscopy in clinical research on musculoskeletal diseases: a systematic review and international Delphi consensus. Rheumatology (Oxford). 2021; 60: 1410-8.
DOI: https://doi.org/10.1093/rheumatology/keaa457
Eden M, Wilkinson S, Murray A, et al. Nailfold capillaroscopy: a survey of current UK practice and ‘next steps’ to increase uptake amongst rheumatologists. Rheumatology (Oxford). 2022 [In press].
DOI: https://doi.org/10.1093/rheumatology/keac133.116
How to Cite
Ingegnoli, F., Cornalba, M., De Angelis, R., Guiducci, S., Giuggioli, D., Pizzorni, C., … Cutolo, M. (2022). Nailfold capillaroscopy in the rheumatological current clinical practice in Italy: results of a national survey. Reumatismo, 74(3). https://doi.org/10.4081/reumatismo.2022.1508
Copyright (c) 2022 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- Y. Emad, T. Gheita, H. Darweesh, P. Klooster, R. Gamal, H. Fathi, N. El-Shaarawy, M. Gamil, M. Hawass, R.M. El-Refai, H. Al-Hanafi, S. Abd-Ellatif, A. Ismail, J. Rasker, Antibodies to extractable nuclear antigens (ENAS) in systemic lupus erythematosus patients: correlations with clinical manifestations and disease activity , Reumatismo: Vol. 70 No. 2 (2018)
- T. Borges, J. Vilaça, S. Ferreira, I. Chora, S. Silva, C. Dias, Systemic sclerosis sine scleroderma: a case report of anterior uveitis , Reumatismo: Vol. 67 No. 1 (2015)
- S. Casigliani Rabl, A. Della Rossa, P. Pepe, A. D'Ascanio, M. Mosca, A. Di Vita, S. Bombardieri, Long-term cyclic intravenous iloprost in systemic sclerosis: clinical experience from a single center , Reumatismo: Vol. 64 No. 3 (2012)
- S. Parisi, M. Bruzzone, C. Centanaro Di Vittorio, A. Laganà, C.L. Peroni, E. Fusaro, Efficacy of bosentan in the treatment of Raynaud’s phenomenon in patients with systemic sclerosis never treated with prostanoids , Reumatismo: Vol. 65 No. 6 (2013)
- S. Soldano, P. Montagna, R. Brizzolara, C. Ferrone, A. Parodio, A. Sulli, B. Seriolo, B. Villaggio, M. Cutolo, Endothelin receptor antagonists: effects on extracellular matrix synthesis in primary cultures of skin fibroblasts from systemic sclerosis patients , Reumatismo: Vol. 64 No. 5 (2012)
- K. Stefanantoni, I. Sciarra, M. Vasile, R. Badagliacca, R. Poscia, M. Pendolino, C. Alessandri, C.D. Vizza, G. Valesini, V. Riccieri, Elevated serum levels of macrophage migration inhibitory factor and stem cell growth factor β in patients with idiopathic and systemic sclerosis associated pulmonary arterial hypertension , Reumatismo: Vol. 66 No. 4 (2014)
- M.A. Cimmino, RETRACTION: Pain in systemic sclerosis , Reumatismo: Vol. 70 No. 2 (2018)
- C. Bruni, S. Bellando-Randone, L. Gargani, E. Picano, A. Pingitore, M. Matucci-Cerinic, S. Guiducci, Critical finger ischemia and myocardial fibrosis development after sudden interruption of sildenafil treatment in a systemic sclerosis patient , Reumatismo: Vol. 68 No. 2 (2016)
- S. Bello, A. Rinaldi, S. Trabucco, L. Serafino, C. Bonali, G. Lapadula, Erasmus syndrome in a marble worker , Reumatismo: Vol. 67 No. 3 (2015)
- E. Bernero, A. Sulli, G. Ferrari, F. Ravera, C. Pizzorni, B. Ruaro, G. Zampogna, E. Alessandri, M. Cutolo, Prospective capillaroscopy-based study on transition from primary to secondary Raynaud’s phenomenon: preliminary results , Reumatismo: Vol. 65 No. 4 (2013)
You may also start an advanced similarity search for this article.
