https://doi.org/10.4081/reumatismo.2022.1507
Association of positive psychological variables with disease activity, functional disability and erythrocyte sedimentation rate in patients with rheumatoid arthritis: a preliminary study
Submitted: 26 June 2022
Accepted: 20 December 2022
Published: 21 March 2023
Accepted: 20 December 2022
Abstract Views: 555
PDF: 318
Supplementary file: 72
Supplementary file: 72
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Rheumatoid arthritis (RA) is a chronic autoimmune disease which has shown positive correlations between negative psychological variables and disease activity in transversal studies and in the follow-up. However, the association of positive psychological variables with disease parameters including disease activity (DAS-28), functional disability (HAQ) and erythrocyte sedimentation rate (ESR) has not been investigated. Patients with RA attending the external consultation of a third level hospital were invited to participate and fill in a questionnaire with personal, disease and psychological variables; body mass index was also obtained as well as ESR. A total of 49 patients were included. The three dependent variables correlated among them, with the highest correlation for DAS-28 and HAQ (r=0.645, p<0.01), followed by somatization and HAQ (r=0.614, p<0.01) or DAS-28 (r=0.537, P<0.01). In addition, HAQ showed negative correlations with environmental mastery (r=- 0.366, p<0.01), personal growth (r=-0.292, p<0.05) and monthly extra money (r=-0.328, p<0.05), and borderline negative correlations with emotion perception (r=-0.279, p=0.053) and self-acceptance (r=-0.250, p=0.08). ESR showed a significant negative correlation with emotion perception (r=-0.475, p<0.01). In conclusion, we observed important correlations of positive psychological variables with disease activity, functional disability and ESR that could be addressed in order to prevent or treat these disease features.
Kojima M, Kojima T, Suzuki S, Oguchi T, Oba M, Tsuchiya H, et al. Depression, inflammation, and pain in patients with rheumatoid arthritis. Arthritis Rheum 2009; 61:1018–24.
DOI: https://doi.org/10.1002/art.24647
Yilmaz V, Umay E, Gündoğdu I, Özgür Karaahmet Z, Öztürk AE. Rheumatoid Arthritis: are psychological factors effective in disease flare? Eur J Rheumatol 2017;4:127–32.
DOI: https://doi.org/10.5152/eurjrheum.2017.16100
Kekow J, Moots R, Khandker R, Melin J, Freundlich B, Singh A. Improvements in patient-reported outcomes, symptoms of depression and anxiety, and their association with clinical remission among patients with moderate-to-severe active early rheumatoid arthritis. Rheumatology 2010; 50:401–9.
DOI: https://doi.org/10.1093/rheumatology/keq327
Michelsen B, Kristianslund EK, Sexton J, Hammer HB, Fagerli KM, Lie E, et al. Do depression and anxiety reduce the likelihood of remission in rheumatoid arthritis and psoriatic arthritis? Data from the prospective multicentre NOR-DMARD study. Ann Rheum Dis 2017;76:1906–10.
DOI: https://doi.org/10.1136/annrheumdis-2017-211284
Overman CL, Bossema ER, van Middendorp H, Wijngaards-de Meij L, Verstappen SMM, Bulder M, et al. The prospective association between psychological distress and disease activity in rheumatoid arthritis: a multilevel regression analysis. Ann Rheum Dis 2015;71:192–7.
DOI: https://doi.org/10.1136/annrheumdis-2011-200338
Low CA, Cunningham, AL, Kao AH, Krishnaswami S, Kuller LH, Wasko MCM. Association between C-reactive protein and depressive symptoms in women with rheumatoid arthritis. Biol Psychol 2009;81:131–4.
DOI: https://doi.org/10.1016/j.biopsycho.2009.02.003
Krol B, Sanderman R, Suurmeijer T, Doeglas D, van Rijswijk M, van Leeuwen M. Disease characteristics, level of self-esteem and psychological well-being in rheumatoid arthritis patients. Scand J Rheumatol 1994;23:8–12.
DOI: https://doi.org/10.3109/03009749409102127
Steptoe A, O’Donnell K, Badrick E, Kumari M, Marmot M. Neuroendocrine and inflammatory factors associated with positive affect in healthy men and women: the whitehall II Study. Am J Epidemiol 2007;167:96–102.
DOI: https://doi.org/10.1093/aje/kwm252
Moreno PI, Moskowitz AL, Ganz PA, Bower JE. Positive affect and inflammatory activity in breast cancer survivors: examining the role of affective arousal. Psychosom Med 2016;78:532–41.
DOI: https://doi.org/10.1097/PSY.0000000000000300
Ironson G, Banerjee N, Fitch C, Krause N. Positive emotional well-being, health Behaviors, and inflammation measured by C-Reactive protein. Soc Sci Med 2018;197:235–43.
DOI: https://doi.org/10.1016/j.socscimed.2017.06.020
Jones DR, Graham-Engeland JE. Positive affect and peripheral inflammatory markers among adults: a narrative review. Psychoneuroendocrinology 2021;123:104892.
DOI: https://doi.org/10.1016/j.psyneuen.2020.104892
Brambila-Tapia AJL, Saldaña-Cruz AM, Meléndez-Monreal KC, Esparza-Guerrero Y, Martínez-Hernández A, Guadalupe Rosales-Torres B, et al. Association of personal, behavioral and positive psychological variables with somatization and number of diseases in Mexican general population: the influence of gender. Psychol Health Med 2021:1-9.
DOI: https://doi.org/10.1080/13548506.2021.1985150
Brambila-Tapia AJL, Macías-Espinoza F, Reyes-Domínguez YA, Ramírez-García ML, Miranda-Lavastida AJ, Ríos-González BE, et al. Association of depression, anxiety, stress and stress-coping strategies with somatization and number of diseases according to sex in the mexican general population. Healthcare (Basel) 2022;10:1048.
DOI: https://doi.org/10.3390/healthcare10061048
Durán J, Domínguez A, Espinoza M. Evaluation of the health assessment questionnaire disability index in chilean patients with rheumatoid arthritis. Rev Méd Chil 2019;147:612–7.
DOI: https://doi.org/10.4067/S0034-98872019000500612
Prevoo MLL, Van’T Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum1995;38:44–8.
DOI: https://doi.org/10.1002/art.1780380107
Beyhaghi H, Reeve BB, Rodgers JE, Stearns SC. Psychometric properties of the four-item morisky green levine medication adherence scale among atherosclerosis risk in communities (ARIC) study participants. Value Health 2016;19:996–1001.
DOI: https://doi.org/10.1016/j.jval.2016.07.001
Ros-Montalbán S, Comas Vives A, Garcia-Garcia M. Validation of the Spanish version of the PHQ-15 questionnaire for the evaluation of physical symptoms in patients with depression and/or anxiety disorders: DEPRE-SOMA study. Actas Esp Psiquiatr 2010;38:345-57.
Radloff L. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1977;1:385-401.
DOI: https://doi.org/10.1177/014662167700100306
Bojorquez-Chapela L, Salgado de Snyder N. Características psicométricas de la escala center for epidemiological studies-depression (CES-D), versiones de 20 y 10 reactivos en mujeres de una zona rural mexicana. Salud Ment 2009;32:297-307.
Garcia-Campayo J, Zamorano E, Ruiz MA, Pardo A, Pérez-Páramo M, López-Gómez V, et al. Cultural adaptation into Spanish of the generalized anxiety disorder-7 (GAD-7) scale as a screening tool. Health Qual Life Outcomes 2010;8:8.
DOI: https://doi.org/10.1186/1477-7525-8-8
Cortina-Guzmán LG, Berenzon-Gom S. Traducción al español y propiedades picométricas del instrumento “positivity self test”. Psicología Iberoamericana 2013;21:53-64.
DOI: https://doi.org/10.48102/pi.v21i1.166
Diaz D., Rodriguez-Carvajal R., Blanco A, Moreno-Jiménez B, Gallardo I, Valle C, et al. Adaptación española de las escalas de bienestar psicológico de Ryff. Psicothema 2006,18:572-7.
Ferrando PJ, Chico E, Tous JM. Propiedades psicométricas del test de optimismo life orientation test. Psicothema 2002;14:673-80.
Chirumbolo A, Picconi L, Morelli M, Petrides KV. The assessment of trait emotional intelligence: psychometric characteristics of the TEIQue-full form in a large italian adult sample. Front Psychol 2019;9:2786.
DOI: https://doi.org/10.3389/fpsyg.2018.02786
Ryff CD. Psychological well-being revisited: advances in science and practice of eudaimonia. Psychother Psychosom 2014;83:10-28.
DOI: https://doi.org/10.1159/000353263
How to Cite
Meléndez-Monreal, K., Brambila-Tapia, A. ., González-Díaz, V., Cerpa-Cruz, S., Gutiérrez-Ureña, S., Yeo-Ayala, M., … Martínez-Bonilla, G. (2023). Association of positive psychological variables with disease activity, functional disability and erythrocyte sedimentation rate in patients with rheumatoid arthritis: a preliminary study. Reumatismo, 74(4). https://doi.org/10.4081/reumatismo.2022.1507
Copyright (c) 2023 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- Y. Emad, T. Gheita, H. Darweesh, P. Klooster, R. Gamal, H. Fathi, N. El-Shaarawy, M. Gamil, M. Hawass, R.M. El-Refai, H. Al-Hanafi, S. Abd-Ellatif, A. Ismail, J. Rasker, Antibodies to extractable nuclear antigens (ENAS) in systemic lupus erythematosus patients: correlations with clinical manifestations and disease activity , Reumatismo: Vol. 70 No. 2 (2018)
- M. Rossini, G. D'Avola, M. Muratore, N. Malavolta, F. Silveri, G. Bianchi, B. Frediani, G. Minisola, M. L. Sorgi, M. Varenna, R. Foti, G. Tartarelli, G. Orsolini, S. Adami, Regional differences of vitamin D deficiency in rheumatoid arthritis patients in Italy , Reumatismo: Vol. 65 No. 3 (2013)
- S. Canestri, M.C. Totaro, E. Serone, B. Tolusso, D. Frezza, E. Gremese, G. Ferraccioli, Association between the response to B cell depletion therapy and the allele*2 of the HS1,2A enhancer in seropositive rheumatoid arthritis patients , Reumatismo: Vol. 64 No. 6 (2012)
- M. Romano, I. Pontikaki, M. Gattinara, I. Ardoino, C. Donati, P. Boracchi, P.L. Meroni, V. Gerloni, Drug survival and reasons for discontinuation of the first course of biological therapy in 301 juvenile idiopathic arthritis patients , Reumatismo: Vol. 65 No. 6 (2013)
- E. Cipriano, F. Ceccarelli, L. Massaro, F. R. Spinelli, C. Alessandri, C. Perricone, G. Valesini, F. Conti, Joint involvement in patients affected by systemic lupus erythematosus: application of the swollen to tender joint count ratio , Reumatismo: Vol. 67 No. 2 (2015)
- A. Marino, I. Pagnini, S. Savelli, D. Moretti, G. Simonini, R. Cimaz, Elbow monoarthritis: an atypical onset of juvenile idiopathic arthritis , Reumatismo: Vol. 64 No. 3 (2012)
- S.L. Bello, L. Serafino, C. Bonali, N. Terlizzi, C. Fanizza, C. Anecchino, G. Lapaldula, Incidence of influenza-like illness into a cohort of patients affected by chronic inflammatory rheumatism and treated with biological agents , Reumatismo: Vol. 64 No. 5 (2012)
- S.M. Gamal, A.K. Alkemary, M.A. Abdo, A.H.M. El Dakrony, Low body mass index in long standing rheumatoid arthritis: relation to RA disease activity and functional indices , Reumatismo: Vol. 70 No. 2 (2018)
- S.M. Günay, Z. Tuna, D. Oskay, Relationship between patient-reported and objective measurements of hand function in patients with rheumatoid arthritis , Reumatismo: Vol. 68 No. 4 (2016)
- G. Lapadula, A. Marchesoni, F. Salaffi, R. Ramonda, C. Salvarani, L. Punzi, L. Costa, F. Caso, D. Simone, G. Baiocchi, C. Scioscia, M. Di Carlo, R. Scarpa, G. Ferraccioli, Evidence-based algorithm for diagnosis and assessment in psoriatic arthritis: results by Italian DElphi in psoriatic Arthritis (IDEA) , Reumatismo: Vol. 68 No. 3 (2016)
You may also start an advanced similarity search for this article.
