https://doi.org/10.4081/reumatismo.2022.1489

Disseminated cutaneous herpes simplex infection after COVID-19 vaccination in a rheumatoid arthritis patient: a case report and review

Vol. 74 No. 2 (2022)
Submitted: 16 March 2022
Accepted: 7 May 2022
Published: 13 September 2022
COVID-19 vaccination, herpes simplex, rheumatologic disorder, autoimmune disorder.
Abstract Views: 1596
PDF: 828
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Authors

D. Mohamadzadeh
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran, Islamic Republic of.
S. Assar
sh758us@yahoo.com
https://orcid.org/0000-0002-7278-492X
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran, Islamic Republic of.
M. Pournazari
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran, Islamic Republic of.
P. Soufivand
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran, Islamic Republic of.
S. Danaei
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran, Islamic Republic of.

Since COVID-19 vaccination started in December 2020, different side effects were reported. This case report describes the possibility of developing disseminated herpes simplex infection after COVID-19 vaccine in a patient with rheumatoid arthritis. In this case report, we describe a 63-year-old Iranian female. She was a known case of seronegative rheumatoid arthritis and presented with generalized papulo-pustular itchy and painful skin lesions which appeared about seven days after the second dose of Sinopharm BIBP COVID-19 vaccine (BIBP-CorV). A biopsy of the skin lesions revealed acantholysis, neutrophils, and enlarged keratinocytes with eosinophilic intra-nuclear inclusions. Findings were consistent with herpes simplex infection. She was successfully treated by acyclovir. Disseminated cutaneous herpes simplex infection may have been triggered by COVID-19 vaccination. Reactivation of herpes virus after COVID-19 vaccines was reported in both rheumatic patients and other individuals. Whether having an underlying autoimmune inflammatory disorder could be an additional risk factor is still unknown.

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How to Cite

Mohamadzadeh, D., Assar, S., Pournazari, M., Soufivand, P., & Danaei, S. (2022). Disseminated cutaneous herpes simplex infection after COVID-19 vaccination in a rheumatoid arthritis patient: a case report and review. Reumatismo, 74(2). https://doi.org/10.4081/reumatismo.2022.1489
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