https://doi.org/10.4081/reumatismo.2022.1483
Clinical profile of patients with lupus psychosis in a Colombian cohort
Submitted: 7 February 2022
Accepted: 15 May 2022
Published: 13 September 2022
Accepted: 15 May 2022
Abstract Views: 1190
PDF: 597
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The objective of this study is to describe the frequency and the clinical, paraclinical, and treatment profile of patients with lupus psychosis in a Colombian cohort of patients with systemic lupus erythematosus (SLE). This retrospective cohort study evaluated epidemiological and clinical characteristics, results of neuroimaging, analysis of the cerebrospinal fluid, treatment, and disease evolution in patients with lupus psychosis. Among 2,479 patients with SLE, six female patients aged between 20 and 50 years with a diagnosis of lupus psychosis were identified. In two patients, psychosis was present at disease onset and in the other four, SLE was already present, although the majority of them were diagnosed less than two years prior to the onset of psychosis. The entire cohort had high disease activity as measured by SLEDAI-2K. We found concomitant cutaneous, joint, and hematological alterations. Cerebrospinal fluid data were obtained in half of the patients and were normal. We performed brain tomography on most of our patients, which was almost always described as normal. In 5 out of 6 patients, the induction therapy to treat psychosis was based on steroids, and in the majority of them, a resolution of psychiatric symptoms was observed after initiating treatment. Lupus psychosis is a rare event that usually occurs early in the course of the disease and is associated with other manifestations of SLE. This investigation mainly found concomitant cutaneous, joint, and hematological manifestations, with a favorable outcome after treatment, as described in the literature.
Hanly JG, Li Q, Su L, Urowitz MB, Gordon C, Bae SC, et al. Psychosis in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study. Arthritis Rheumatol. 2019; 71: 281-89.
DOI: https://doi.org/10.1002/art.40764
Pego-Reigosa JM, Isenberg DA. Psychosis due to systemic lupus erythematosus: Characteristics and long-term outcome of this rare disease manifestation. Rheumatology. 2008; 47: 1498-502.
DOI: https://doi.org/10.1093/rheumatology/ken260
The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum. 1999; 42: 599-608.
Bertsias GK, Ioannidis JP, Aringer M, et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Ann Rheum Dis. 2010; 69: 2074-82.
DOI: https://doi.org/10.1136/ard.2010.130476
Hanly JG, Urowitz MB, Sanchez-Guerrero J, et al. Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: an international inception cohort study. Arthritis Rheum. 2007; 56: 265-73.
DOI: https://doi.org/10.1002/art.22305
Hanly JG, Urowitz MB, Su L, et al. Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study. Arthritis Rheum. 2008; 59: 721-29.
DOI: https://doi.org/10.1002/art.23566
Gladman DD, Ibañez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol. 2002; 29: 288-91.
Appenzeller S, Cendes F, Costallat LTL. Acute psychosis in systemic lupus erythematosus. Rheumatol Int. 2008; 28: 237-43.
DOI: https://doi.org/10.1007/s00296-007-0410-x
Kumar P, Kumar A, Thakur V, et al. Acute psychosis as the presenting manifestation of lupus. J Fam Med Prim Care. 2021; 10: 1050-3.
DOI: https://doi.org/10.4103/jfmpc.jfmpc_1475_20
[No authors listed]. Acute adverse reactions to prednisone in relation to dosage. Clin Pharmacol Ther. 1972; 13: 694-98.
DOI: https://doi.org/10.1002/cpt1972135part1694
Warrington TP, Bostwick JM. Psychiatric adverse effects of corticosteroids. Mayo Clin Proc. 2006; 81: 1361-67.
DOI: https://doi.org/10.4065/81.10.1361
Bonfa E, Golombek SJ, Kaufman LD, et al. Association between lupus psychosis and anti-ribosomal P protein antibodies. N Engl J Med. 1987; 317: 265-71.
DOI: https://doi.org/10.1056/NEJM198707303170503
Hirohata S, Kanai Y, Mitsuo A, et al. Differential characteristics of lupus psychosis and steroid psychosis. Proceedings of the 2018 ACR/ARHP Annual Meeting; 2018 Oct 21; Chicago (IL). Arthritis Rheumatol. 2018; 70 (suppl 10).
DOI: https://doi.org/10.1002/art.40700
Viana VT, Durcan L, Bonfa E, Elkon KB. Ribosomal P antibody: 30 years on the road. Lupus. 2017; 26: 453-62.
DOI: https://doi.org/10.1177/0961203317690243
Hanly JG. Avoiding diagnostic pitfalls in neuropsychiatric lupus: The importance of attribution. Lupus. 2017; 26: 497-503.
DOI: https://doi.org/10.1177/0961203317690244
Nayak RB, Bhogale GS, Patil NM, Chate SS. Psychosis in patients with systemic lupus erythematosus. Indian J Psychol Med. 2012; 34: 90-3.
DOI: https://doi.org/10.4103/0253-7176.96170
Lieberman JA, Stroup TS, McEvoy JP, et al; Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 2005; 353: 1209-23.
DOI: https://doi.org/10.1056/NEJMoa051688
How to Cite
Muñoz-Urbano, M., Sánchez-Bautista, J., Ramirez, A., Quintero-González, D. ., Santamaria-Alza, Y., & Vanegas-García, A. (2022). Clinical profile of patients with lupus psychosis in a Colombian cohort. Reumatismo, 74(2). https://doi.org/10.4081/reumatismo.2022.1483
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