https://doi.org/10.4081/reumatismo.2021.1448
Multisystemic inflammatory syndrome related to COVID-19, with latent tuberculosis in bone marrow, and satisfactory response to tocilizumab, in a 7-year-old boy
Submitted: 15 August 2021
Accepted: 11 November 2021
Published: 7 February 2022
Accepted: 11 November 2021
Abstract Views: 5940
PDF: 626
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) or multisystem inflammatory syndrome in children (MIS-C) is a new acute-onset systemic inflammatory disease, which mainly affects children. Latent tuberculosis infection (LTBI) is characterized by the presence of immune sensitization to Mycobacterium tuberculosis (MTB) in the absence of any clinical or radiological evidence of active disease. We present a child with MIS-C related to COVID-19, with latent TB in the bone marrow, and satisfactory response to tocilizumab. It is important to pay attention in the investigation of TB cases in countries with a high prevalence of tuberculosis, especially when opting for immunusuppression.
OPS (Organización Panamericana de la Salud). La OMS declara que el nuevo brote de coronavirus es una emergencia de salud pública de importancia internacional; 30 Jan 2020. Available from: https://www.paho.org/es/noticias/30-1-2020-oms-declara-que-nuevo-brote-coronavirus-es-emergencia-salud-publica-importancia
Samudrala PK, Kumar P, Choudhary K, et al. Virology, pathogenesis, diagnosis and in-line treatment of COVID-19. Eur J Pharmacol. 2020; 883: 173375.
DOI: https://doi.org/10.1016/j.ejphar.2020.173375
World Health Organization. Multisystem inflammatory syndrome in children and adolescents with COVID-19: Scientific Brief. 2020. Available from: https://www.who.int/publications/i/item/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19
Royal College of Paediatrics and Child Health. Guidance: Paediatric multisystem inflammatory syndrome temporally associated with COVID-19. https://www.rcpch.ac.uk/sites/default/files/2020-05/COVID-19-Paediatric-multisystem-%20inflammatory%20syndrome-20200501.pdf
Centers for Disease Control and Prevention. Information for Healthcare Providers about Multisystem Inflammatory Syndrome in Children (MIS-C). Available from: https://www.cdc.gov/mis/hcp/index.html
Fernández-Sarmiento J, De Souza D, Jabornisky R, et al. Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): a narrative review and the viewpoint of the Latin American Society of Pediatric Intensive Care (SLACIP) Sepsis Committee BMJ Paediatrics Open 2021;5:e000894.
DOI: https://doi.org/10.1136/bmjpo-2020-000894
Henderson LA, Canna SW, Friedman KG, et al. American College of Rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and hyperinflammation in pediatric COVID-19: Version 2. Arthritis Rheumatol. 2021; 73: e13-e29.
DOI: https://doi.org/10.1002/art.41616
McArdle AJ, Vito O, Patel H, et al. BATS Consortium. Treatment of multisystem inflammatory syndrome in children. N Engl J Med. 2021 [Epub ahead of print].
DOI: https://doi.org/10.1056/NEJMoa2102968
Mayito J, Andia I, Belay M, et al. Anatomic and cellular niches for mycobacterium tuberculosis in latent tuberculosis infection. J Infect Dis. 2019; 219: 685-94.
Bandyopadhyay A, Palepu S, Bandyopadhyay K, Handu S. COVID-19 and tuberculosis co-infection: a neglected paradigm. Monaldi Arch Chest Dis. 2020; 90(3).
DOI: https://doi.org/10.4081/monaldi.2020.1437
Thomas TA. Tuberculosis in children. Pediatr Clin North Am. 2017; 64: 893-909.
DOI: https://doi.org/10.1016/j.pcl.2017.03.010
Carvalho I, Goletti D, Manga S, et al. Managing latent tuberculosis infection and tuberculosis in children. Pulmonology. 2018; 24: 106-14.
DOI: https://doi.org/10.1016/j.rppnen.2017.10.007
Godfred-Cato S, Bryant B, Leung J, et al. California MIS-C Response Team. COVID-19-associated multisystem inflammatory syndrome in children - United States, March-July 2020. MMWR Morb Mortal Wkly Rep. 2020; 69: 1074-80.
DOI: https://doi.org/10.15585/mmwr.mm6932e2
Cattalini M, Taddio A, Bracaglia C, et al. Childhood multisystem inflammatory syndrome associated with COVID-19 (MIS-C): a diagnostic and treatment guidance from the Rheumatology Study Group of the Italian Society of Pediatrics. Ital J Pediatr. 2021; 47: 24.
DOI: https://doi.org/10.1186/s13052-021-00980-2
Hoste L, Van Paemel R, Haerynck F. Multisystem inflammatory syndrome in children related to COVID-19: a systematic review. Eur J Pediatr. 2021; 18: 1-16.
DOI: https://doi.org/10.1101/2020.08.17.20173641
Jonat B, Gorelik M, Boneparth A, et al. Multisystem inflammatory syndrome in children associated with coronavirus disease 2019 in a children’s hospital in New York City: patient characteristics and an institutional protocol for evaluation, management, and follow-up. Pediatr Crit Care Med. 2021; 22: e178-91.
DOI: https://doi.org/10.1097/PCC.0000000000002598
McIntosh AM, Tong S, Deakyne SJ, et al. Validation of the vasoactive-inotropic score in pediatric sepsis. Pediatr Crit Care Med. 2017; 18: 750-7.
DOI: https://doi.org/10.1097/PCC.0000000000001191
World Health Organization. Global tuberculosis report; 2019. Available from: https://apps.who.int/iris/bitstream/handle/10665/329368/9789241565714-eng.pdf
World Health Organization. Global tuberculosis report; 2020. Available from: https://apps.who.int/iris/bitstream/handle/10665/336069/9789240013131-eng.pdf
Tadolini M, Codecasa LR, García-García JM, et al. Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases. Eur Resp J. 2020; 2001398.
DOI: https://doi.org/10.1183/13993003.02328-2020
Mayito J, Andia I, Belay M, et al. Anatomic and Cellular Niches for Mycobacterium tuberculosis in latent tuberculosis infection. J Infect Dis. 2019; 219: 685-94.
DOI: https://doi.org/10.1093/infdis/jiy579
Batu ED, Özen S. Implications of COVID-19 in pediatric rheumatology. Rheumatol Int. 2020; 40: 1193-213.
DOI: https://doi.org/10.1007/s00296-020-04612-6
Lobo N, Brooks NA, Zlotta AR, et al. 100 years of Bacillus Calmette-Guérin immunotherapy: from cattle to COVID-19. Nat Rev Urol. 2021; 18: 611-22.
DOI: https://doi.org/10.1038/s41585-021-00481-1
Miller A, Reandelar MJ, Fasciglione K, et al. Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study. medRxiv. 2020. [Epub ahead of print].
DOI: https://doi.org/10.1101/2020.03.24.20042937
Torun S, Ozkaya S, Şen N, et al. The Relationship between COVID-19 severity and Bacillus Calmette-Guérin (BCG)/Mycobacterium tuberculosis exposure history in healthcare workers: a multi-center study. Pathog Glob Health. 2021: 1-7. [Epub ahead of print].
DOI: https://doi.org/10.1080/20477724.2021.1927605
Chaisemartin C, de Chaisemartin L. Bacille Calmette-Guérin vaccination in infancy does not protect against coronavirus disease 2019 (COVID-19): evidence from a natural experiment in Sweden. Clin Infect Dis. 2021; 72: e501-5.
DOI: https://doi.org/10.1093/cid/ciaa1223
Patella V, Delfino G, Bruzzese D, et al. The bacillus Calmette-Guérin vaccination allows the innate immune system to provide protection from severe COVID-19 infection. Proc Natl Acad Sci U S A. 2020; 117: 25205-6.
DOI: https://doi.org/10.1073/pnas.2015234117
How to Cite
Morel, Z., Suarez, R., Avalos, E., Velázquez, S., Martínez, F., Lezcano, V., … Samudio, G. (2022). Multisystemic inflammatory syndrome related to COVID-19, with latent tuberculosis in bone marrow, and satisfactory response to tocilizumab, in a 7-year-old boy. Reumatismo, 73(4). https://doi.org/10.4081/reumatismo.2021.1448
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