https://doi.org/10.4081/reumatismo.2021.1368
Voriconazole-induced periostitis
Submitted: 11 November 2020
Accepted: 23 January 2021
Published: 19 April 2021
Accepted: 23 January 2021
Abstract Views: 3734
PDF: 727
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Voriconazole is a fluorinated drug from the triazole group that is widely used in the prophylaxis and treatment of fungal infections in immunosuppressed patients. Chronic use of this medication can generate, as an adverse effect, a multifocal, asymmetric, diffuse and nodular periosteal reaction, associated with severe and disabling skeletal pain and elevated alkaline phosphatase and serum fluoride. Radiography is the imaging technique of choice for periostitis diagnosis. In general, clinical manifestations and radiographic findings disappear, when the drug is discontinued. We report the clinical case of a 44 year-old woman diagnosed with acute myeloid leukemia, who developed an invasive fungal infection treated with voriconazole after a stem cell transplant. Nine months after starting antifungal treatment, she manifested symptoms and radiological signs compatible with periostitis. Due to clinical suspicion, we decided to suspend voriconazole, with consequent resolution of clinical manifestations and radiological findings.
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DOI: https://doi.org/10.2214/AJR.18.19991
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DOI: https://doi.org/10.1093/cid/ciu513
Elmore S, Wisse A, Chapin RW, Whelan TP, Silver RM. Voriconazole-associated periostitis presenting as hypertrophic osteoarthropathy following lung transplantation report of two cases and review of the literature. Semin Arthritis Rheum. 2019; 49: 319-23.
DOI: https://doi.org/10.1016/j.semarthrit.2019.04.003
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How to Cite
Fernández Ávila, D., Diehl, M., Degrave, A., Buttazzoni, M., Pereira, T., Aguirre, M., … Scolnik, M. (2021). Voriconazole-induced periostitis. Reumatismo, 73(1), 44–47. https://doi.org/10.4081/reumatismo.2021.1368
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