https://doi.org/10.4081/reumatismo.2020.1267
Different fracture risk profile in patients treated with anti-osteoporotic drugs in real-life
Accepted: 15 April 2020
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
In this retrospective study, we intended to investigate the baseline fracture risk profile in patients who started treatment with different anti-osteoporotic medications. We analyzed retrospectively the fracture risk calculated with DeFRA, a validated FRAX derived tool, in women who started an anti-osteoporotic treatment from 2010 to 2017. We analyzed baseline data of 12,024 post-menopausal women aged over 50 years. Teriparatide initiators had a baseline 10-year risk of major osteoporotic fracture of 82.1% with a Standard Deviation (SD) of 66.5%. Denosumab initiators and zoledronic acid initiators had a greater 10-year baseline risk of fracture (54.3%, SD 46.5% and 47.0%, SD 42.0 respectively) than patients initiated on alendronate (24.9%, SD 34.6%) and patients initiated on risedronate (23.9%, SD 24.1%). Using DeFRA, a FRAX™ derived tool, we showed significantly different fracture risk profiles in women who were started on various therapeutic agents for the treatment of osteoporosis in routine clinical practice.
How to Cite
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- D.J. Manzella, L. Vicente, A.A. Pérez de la Hoz, R.J. Zamora, G. De Rosa, A.A. Pisarevsky, Catastrophic antiphospholipid syndrome as a complication of systemic sclerosis , Reumatismo: Vol. 71 No. 2 (2019)
- M. Sebastiani, A. Manfredi, M. Colaci, D. Giuggioli, R. La Sala, N. Elkhaldi, A. Antonelli, C. Ferri, Correlation of a quantitative videocapillaroscopic score with the development of digital skin ulcers in scleroderma patients , Reumatismo: Vol. 60 No. 3 (2008)
- M.A. Cimmino, F. Salaffi, I. Olivieri, F. Trotta, P. Sarzi Puttini, W. Grassi, V. Modena, F.P. Cantatore, S. Bombardieri, S. Adami, L. Punzi, G. Lapadula, Gruppo MI.D.A., Pain patterns in italian patients with osteoarthritis: preliminary results of the MI.D.A. Study (Misurazione del Dolore nell’Artrosi) , Reumatismo: Vol. 56 No. 4 (2004)
- M. Cutolo, IL-1Ra: its role in rheumatoid arthritis , Reumatismo: Vol. 56 No. s1 (2004)
- E. Bartoloni Bocci, S. Marchesi, F. Delle Monache, G. Vaudo, A. Giordano, F. Ragni Alunni, C. Angrisani, E. Mannarino, Y. Shoenfeld, R. Gerli, Subclinical atherosclerosis in young patients with rheumatoid arthritis and low disease activity , Reumatismo: Vol. 57 No. 1 (2005)
- B. Marasini, M. Massarotti, R. Cossutta, L. Massironi, A. Mantero, Pulmonary hypertension in autoimmune rheumatic diseases , Reumatismo: Vol. 57 No. 2 (2005)
- P. Ostuni, M.E.C. Battista, A. Furlan, Efficacy of Carbopol 974P (Siccafluid) in the treatment of severe to moderate keratoconjunctivitis sicca (KCS) in patients with primary Sjögren’s syndrome (SS) not responding to standard treatment with artificial tears , Reumatismo: Vol. 57 No. 2 (2005)
- A.R. Carone, S. D'Amore, L. Albanese, F. Craig, P. Scagliusi, M. D'Amore, Hospital anxiety and depression , Reumatismo: Vol. 59 No. 4 (2007)
You may also start an advanced similarity search for this article.
