https://doi.org/10.4081/reumatismo.2020.1243
Association between red cell distribution width and response to methotrexate in rheumatoid arthritis
Accepted: 6 December 2019
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Red cell distribution width (RDW) is an unconventional biomarker of inflammation. We aimed to explore its role as a predictor of treatment response in rheumatoid arthritis (RA). Eighty-two RA patients (55 females), median age [interquartile range] 63 years [52-69], were selected by scanning the medical records of a rheumatology clinic, to analyze the associations between baseline RDW, disease activity scores and inflammatory markers, as well as the relationship between RDW changes following methotrexate (MTX) and treatment response. The lower the median baseline RDW, the greater were the chances of a positive EULAR response at three months, 13.5% [13.0-14.4] being among those with good response, vs 14.0% [13.2-14.7] and 14.2% [13.5- 16.0] (p=0.009) among those with moderate and poor response, respectively. MTX treatment was followed by a significant RDW increase (p<0.0001). The increase of RDW was greater among patients with good EULAR response, becoming progressively smaller in cases with moderate and poor response (1.0% [0.4-1.4] vs. 0.7 [0.1-2.0] vs. 0.3 [-0.1-0.8]; p=0.03). RDW is a strong predictor of early response to MTX in RA. RDW significantly increases after MTX initiation in parallel to treatment response, suggesting a role as a marker of MTX effectiveness.
How to Cite
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- M. Covelli, P. Sarzi-Puttini, F. Atzeni, P. Macchioni, Safety of rituximab in rheumatoid arthritis , Reumatismo: Vol. 62 No. 2 (2010)
- M. Fabris, E. Di Poi, S. Sacco, G. Damante, L. Sinigaglia, G. Ferraccioli, TNF-α gene polymorphisms in rheumatoid arthritis patients treated with anti-TNF-α agents: preliminary results , Reumatismo: Vol. 54 No. 1 (2002)
- S. Alivernini, A.L. Fedele, I. Cuoghi, B. Tolusso, G. Ferraccioli, Citrullination: the loss of tolerance and development of autoimmunity in rheumatoid arthritis , Reumatismo: Vol. 60 No. 2 (2008)
- G. Pasero, P. Marson, short history of anti-rheumatic therapy. IV. Corticosteroids , Reumatismo: Vol. 62 No. 4 (2010)
- D. Filippini, F. Colombo, S. Jann, R. Corneo, B. Canesi, Central nervous system involvement in patients with HCV-related cryoglobulinemia: review and a case report , Reumatismo: Vol. 54 No. 2 (2002)
- M. Fabris, B. Tolusso, E. Gremese, P. Tomietto, G. Ferraccioli, Analysis of the kinetic of expression of tristetraprolin and HuR by rheumatoid arthritis patients pheripheral blood mononuclear cells stimulated with lipopolysaccharide , Reumatismo: Vol. 56 No. 2 (2004)
- G. Ferraccioli, Reconstructing the pyramid as a therapeutic approach to rheumatoid arthritis , Reumatismo: Vol. 56 No. s1 (2004)
- W. Troise Rioda, A. Nervetti, G. Ugolotti, G. Adorni, Knee radiosynovectomy with Y90 in patients with rheumatoid arthritis: our experiences , Reumatismo: Vol. 60 No. 3 (2008)
- F. Pasqui, L. Mastrodonato, F. Ceccarelli, R. Scrivo, L. Magrini, V. Riccieri, M. Di Franco, M. Gentili, G. Valesini, A. Spadaro, Occupational therapy in rheumatoid arthritis: short term prospective study in patients treated with anti-TNF-alpha drugs , Reumatismo: Vol. 58 No. 3 (2006)
- P. Sarzi- Puttini, M. Antivalle, A. Marchesoni, E.G. Favalli, R. Gorla, M. Filippini, R. Caporali, F. Bobbio-Pallavicini, C. Montecucco, F. Atzeni, Efficacy and safety of anti-TNF agents in the Lombardy rheumatoid arthritis network (LORHEN) , Reumatismo: Vol. 60 No. 4 (2008)
<< < 15 16 17 18 19 20 21 22 23 24 > >>
You may also start an advanced similarity search for this article.
