https://doi.org/10.4081/reumatismo.2019.1200
Spa therapy induces clinical improvement and protein changes in patients with chronic back pain
Accepted: 13 February 2019
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
This study is primarily aimed at assessing serum changes on a large panel of proteins in patients with chronic back pain following spa therapy, as well as evaluating different spa therapy regimens as a preliminary exploratory clinical study. Sixty-six patients with chronic back pain secondary to osteoarthritis were randomly enrolled and treated with daily mud packs and bicarbonate-alkaline mineral water baths, or a thermal hydrotherapy rehabilitation scheme, the combination of the two regimens or usual medication only (control group), for two weeks. Clinical variables were evaluated at baseline, after 2 and 12 weeks. One thousand serum proteins were tested before and after a two-week mud bath therapy. All spa treatment groups showed clinical benefit as determined by improvements in VAS pain, Roland Morris disability questionnaire and neck disability index at both time points. The following serum proteins were found greatly increased (≥2.5 fold) after spa treatment: inhibin beta A subunit (INHBA), activin A receptor type 2B (ACVR2B), angiopoietin-1 (ANGPT1), beta-2-microglobulin (B2M), growth differentiation factor 10 (GDF10), C-X-C motif chemokine ligand 5 (CXCL5), fibroblast growth factor 2 (FGF2), fibroblast growth factor 12 (FGF12), oxidized low density lipoprotein receptor 1 (OLR1), matrix metallopeptidase 13 (MMP13). Three proteins were found greatly decreased (≤0.65 fold): apolipoprotein C-III (Apoc3), interleukin 23 alpha subunit p19 (IL23A) and syndecan-1 (SDC1). Spa therapy was confirmed as beneficial for chronic back pain and proved to induce changes in proteins involved in functions such as gene expression modulation, differentiation, angiogenesis, tissue repair, acute and chronic inflammatory response.
How to Cite
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- F. Oliviero, R. Ramonda, A. Hoxha, A. Scanu, P. Galozzi, M. Favero, P. Frallonardo, L. Punzi, Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study , Reumatismo: Vol. 72 No. 3 (2020)
- M. Rossini, F. Bertoldo, R. Lovato, R. Bortolotti, D. Gatti, S. Adami, Use of nonsteroidal anti-inflammatory drugs in patients with vertebral osteoporotic fractures , Reumatismo: Vol. 54 No. 4 (2002)
- M.A. Cimmino, A. Zampogna, S. Murroni, S. Baruffi, G. Alessio, T. Maio, G.S. Mela, Prevalence studies in rheumatology: the methodology of the Chiavari study , Reumatismo: Vol. 54 No. 1 (2002)
- C.G.V. de Carvalho, B. Bayeh, F.H.C. de Souza, R. Miossi, P.T. Inaoka, T. Matsushita, N. Mugii, S.K. Shinjo, Patients with anti-small ubiquitin-like modifier activating enzyme-positive dermatomyositis resembling antisynthetase syndrome with poor prognosis: a bicentric international retrospective study and literature review , Reumatismo: Early Access
- G. Frosi, A. Sulli, M. Testa, M. Cutolo, The sterno-clavicular joint: anatomy, biomechanic, clinical features and aspects of manual therapy , Reumatismo: Vol. 56 No. 2 (2004)
- A. Migliore, S. Tormenta, C. Valente, U. Massafra, L.S. Martin Martin, E. Carmenini, A. Bernardini, A. Alimonti, Intra-articulaar treatment with Hylan G-F 20 under ultrasound guidance in hip osteoarthritis. Clinical results after 12 months follow-up , Reumatismo: Vol. 57 No. 1 (2005)
- A. Migliore, S. Tormenta, F. Iannesi, E. Mascheroni, E. Barbati, A. Capuano, M. Diaco, U. Massafra, C. Padalino, F. Vacca, A. Alimonti, L.S. Martin, M. Granata, Correlation between radiologic and ultrasonographic patterns and clinical manifestations in symptomatic hip osteoarthritis , Reumatismo: Vol. 59 No. 1 (2007)
- G. Arioli, S. Maddali Bongi, N. Pappone, The rehabilitative approach in rheumatoid arthritis , Reumatismo: Vol. 60 No. 4 (2008)
- M.T. Riccardi, A. Chialà, F. Iannone, V. Grattagliano, M. Covelli, G. Lapadula, Treatment of digital ulcers in systemtic sclerosis with endothelin-1 receptor antagonist (bosentan) , Reumatismo: Vol. 59 No. 2 (2007)
- F. Pasqui, L. Mastrodonato, F. Ceccarelli, R. Scrivo, L. Magrini, V. Riccieri, M. Di Franco, M. Gentili, G. Valesini, A. Spadaro, Occupational therapy in rheumatoid arthritis: short term prospective study in patients treated with anti-TNF-alpha drugs , Reumatismo: Vol. 58 No. 3 (2006)
<< < 13 14 15 16 17 18 19 20 21 22 > >>
You may also start an advanced similarity search for this article.
