https://doi.org/10.4081/reumatismo.2019.1102

Novel autoantibodies in rheumatoid arthritis

Vol. 71 No. 1 (2019)
Submitted: 28 November 2017
Accepted: 6 September 2018
Published: 1 April 2019
Rheumatoid arthritis, Autoantibodies, Citrullination.
Abstract Views: 2855
PDF: 1649
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

A.F. Bonifacio
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
A. Alunno
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
G.M.C. La Paglia
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
E. Valentini
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
M.C. Leone
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
E. Bartoloni
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Roberto Gerli
roberto.gerli@unipg.it
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.

Rheumatoid factor and antibodies against cyclic citrullinated peptides represent a diagnostic hallmark in rheumatoid arthritis (RA). However, over the last decades many other autoantibodies have been identified. Several proteins can trigger an aberrant autoimmune response in their native form while others acquire this feature after post-translational modifications such as citrullination, carbamylation or acetylation. It is of interest that also the enzymes catalyzing such post-translational modifications (e.g. the protein arginine deiminases) can transform themselves into autoantibodies in RA. The purpose of this review article is to provide an overview of relevant literature published over the last years regarding novel autoantibodies and their possible diagnostic and prognostic significance in RA.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

Bonifacio, A., Alunno, A., La Paglia, G., Valentini, E., Leone, M., Bartoloni, E., & Gerli, R. (2019). Novel autoantibodies in rheumatoid arthritis. Reumatismo, 71(1), 1–12. https://doi.org/10.4081/reumatismo.2019.1102

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Similar Articles

<< < 1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.