https://doi.org/10.4081/reumatismo.2019.1102

Novel autoantibodies in rheumatoid arthritis

Vol. 71 No. 1 (2019)
Submitted: 28 November 2017
Accepted: 6 September 2018
Published: 1 April 2019
Rheumatoid arthritis, Autoantibodies, Citrullination.
Abstract Views: 2859
PDF: 1650
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Authors

A.F. Bonifacio
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
A. Alunno
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
G.M.C. La Paglia
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
E. Valentini
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
M.C. Leone
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
E. Bartoloni
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Roberto Gerli
roberto.gerli@unipg.it
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.

Rheumatoid factor and antibodies against cyclic citrullinated peptides represent a diagnostic hallmark in rheumatoid arthritis (RA). However, over the last decades many other autoantibodies have been identified. Several proteins can trigger an aberrant autoimmune response in their native form while others acquire this feature after post-translational modifications such as citrullination, carbamylation or acetylation. It is of interest that also the enzymes catalyzing such post-translational modifications (e.g. the protein arginine deiminases) can transform themselves into autoantibodies in RA. The purpose of this review article is to provide an overview of relevant literature published over the last years regarding novel autoantibodies and their possible diagnostic and prognostic significance in RA.

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How to Cite

Bonifacio, A., Alunno, A., La Paglia, G., Valentini, E., Leone, M., Bartoloni, E., & Gerli, R. (2019). Novel autoantibodies in rheumatoid arthritis. Reumatismo, 71(1), 1–12. https://doi.org/10.4081/reumatismo.2019.1102

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