https://doi.org/10.4081/reumatismo.2019.1095
Catastrophic antiphospholipid syndrome as a complication of systemic sclerosis
Accepted: 17 December 2018
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
A 62-year-old man with a history of systemic sclerosis was admitted with diffuse alveolar hemorrhage and acute kidney injury without clinical data suggestive of glomerulonephritis. Laboratory tests showed anemia, leukocytosis with neutrophilia, thrombocytopenia, elevated serum creatinine and metabolic acidosis. Antinuclear antibodies were positive at a titer of 1/640 (speckled, 1/160; nucleolar, 1/320) while rheumatoid factor, anti Scl-70, anti-centromere, anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibodies were negative and serum complement levels were within normal range. During the following days, the patient developed multiple organ failure and, eventually, died. Lupus anticoagulant was revealed positive after the patient’s death, suggesting a catastrophic antiphospholipid syndrome. Clinical data and autopsy were consistent with this diagnosis.
How to Cite
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Similar Articles
- W. Grassi, C. Montecucco, Approved indications and other possible utilizations of anti-TNFa biologic drugs , Reumatismo: Vol. 57 No. s4 (2005)
- M. Cazzola, P. Sarzi-Puttini, S. Stisi, M. Di Franco, L. Bazzichi, R. Carignola, R.H Gracely, F. Salaffi, F. Marinangeli, R. Torta, M.A. Giamberardino, D. Buskila, M. Spath, G. Biasi, G. Cassisi, R. Casale, L. Altomonte, G. Arioli, A. Alciati, A. Marsico, F. Ceccherelli, G. Leardini, R. Gorla, F. Atzeni, Fibromyalgia syndrome: definition and diagnostic aspects , Reumatismo: Vol. 60 No. s1 (2008)
- D.H.S. Attia, R.A. Abdel Noor, Severe Behçet’s disease equally affects both genders in Egyptian patients: A multicentre retrospective follow-up study , Reumatismo: Vol. 71 No. 4 (2019)
- M.A. Cimmino, A. Zampogna, S. Murroni, S. Baruffi, G. Alessio, T. Maio, G.S. Mela, Prevalence studies in rheumatology: the methodology of the Chiavari study , Reumatismo: Vol. 54 No. 1 (2002)
- L.J. Dominguez, M. Muratore, E. Quarta, G. Zagone, M. Barbagallo, Osteoporosis and diabetes , Reumatismo: Vol. 56 No. 4 (2004)
- M. Parodi, L. Bensi, T. Maio, G.S. Mela, M.A. Cimmino, Comorbidities in rheumatoid arthritis: analysis of hospital discharge records , Reumatismo: Vol. 57 No. 3 (2005)
- C. Botsios, P. Sfriso, A. Furlan, P. Ostuni, M. Biscaro, U. Fiocco, S. Todesco, L. Punzi, Anakinra, a recombinant human IL-1 receptor antagonist, in clinical practice. Outcome in 60 patients with severe rheumatoid arthritis , Reumatismo: Vol. 59 No. 1 (2007)
- M. Cazzola, P. Sarzi-Puttini, D. Buskila, F. Atzeni, Pharmacological treatment of fibromyalgia , Reumatismo: Vol. 59 No. 4 (2007)
- R. Ramírez-Sandoval, M. Vázquez-del-Mercado, A. Daneri-Navarro, E. López-Robles, J.J. Bollain-y-Goitia, E. Avalos-Diaz, R. Herrera-Esparza, Intracellular antigens released from Balb/c mice kidneys under chemically induced apoptosis and/or necrosis , Reumatismo: Vol. 60 No. 2 (2008)
- A.R. Giardina, A. Accardo-Palumbo, F. Ciccia, A. Ferrante, A. Principato, R. Impastato, G. Triolo, Blocking TNF in vitro with infliximab determines the inhibition of expansion and interferon gamma production of Vγ9/Vδ2 T lymphocytes from patients with active rheumatoid arthritis. A role in the susceptibility to tuberculosis? , Reumatismo: Vol. 61 No. 1 (2009)
<< < 36 37 38 39 40 41 42 43 44 > >>
You may also start an advanced similarity search for this article.
