https://doi.org/10.4081/reumatismo.2019.1095
Catastrophic antiphospholipid syndrome as a complication of systemic sclerosis
Submitted: 7 February 2018
Accepted: 17 December 2018
Published: 9 July 2019
Accepted: 17 December 2018
Abstract Views: 1228
PDF: 932
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
A 62-year-old man with a history of systemic sclerosis was admitted with diffuse alveolar hemorrhage and acute kidney injury without clinical data suggestive of glomerulonephritis. Laboratory tests showed anemia, leukocytosis with neutrophilia, thrombocytopenia, elevated serum creatinine and metabolic acidosis. Antinuclear antibodies were positive at a titer of 1/640 (speckled, 1/160; nucleolar, 1/320) while rheumatoid factor, anti Scl-70, anti-centromere, anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibodies were negative and serum complement levels were within normal range. During the following days, the patient developed multiple organ failure and, eventually, died. Lupus anticoagulant was revealed positive after the patient’s death, suggesting a catastrophic antiphospholipid syndrome. Clinical data and autopsy were consistent with this diagnosis.
How to Cite
Manzella, D., Vicente, L., Pérez de la Hoz, A., Zamora, R., De Rosa, G., & Pisarevsky, A. (2019). Catastrophic antiphospholipid syndrome as a complication of systemic sclerosis. Reumatismo, 71(2), 92–98. https://doi.org/10.4081/reumatismo.2019.1095
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