https://doi.org/10.4081/reumatismo.2018.1084

Histopathology of the gut in rheumatic diseases

Vol. 70 No. 3 (2018): Monographic issue on Histopathology in Rheumatic Diseases
Submitted: 7 October 2017
Accepted: 27 June 2018
Published: 3 October 2018
Intestinal inflammation, Symbiosis, Ankylosing spondylitis, Rheumatoid arthritis, Behçet’s disease, Systemic lupus erythematosus, Systemic sclerosis.
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Authors

F. Macaluso
Rheumatology Unit, University of Palermo, Italy.
G. Guggino
Rheumatology Unit, University of Palermo, Italy.
A. Rizzo
Pathology Unit, Azienda Ospedaliera Villa Sofia Cervello, Palermo, Italy.
A. Ferrante
Rheumatology Unit, University of Palermo, Italy.
F. Ciccia
francesco.ciccia@unipa.it
Rheumatology Unit, University of Palermo, Italy.

The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity to non-self-antigens. Various evidence indicates that intestinal inflammation occurs in patients with rheumatic diseases. In many rheumatic diseases intestinal inflammation appears to be linked to dysbiosis and possibly represents the common denominator in the pathogenesis of different rheumatic diseases. The continuative interaction between dysbiosis and the intestinal immune system may lead to the aberrant activation of immune cells that can re-circulate from the gut to the sites of extraintestinal inflammation as observed in patients with ankylosing spondylitis. The exact contribution of genetic factors in the development of intestinal inflammation in rheumatic diseases needs to be clarified.

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How to Cite

Macaluso, F., Guggino, G., Rizzo, A., Ferrante, A., & Ciccia, F. (2018). Histopathology of the gut in rheumatic diseases. Reumatismo, 70(3), 178–186. https://doi.org/10.4081/reumatismo.2018.1084

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