https://doi.org/10.4081/reumatismo.2018.1053

Histopathology of salivary glands

Vol. 70 No. 3 (2018): Monographic issue on Histopathology in Rheumatic Diseases
Submitted: 3 August 2017
Accepted: 5 November 2017
Published: 3 October 2018
Primary Sjögren’s syndrome, IgG4, Amyloidosis, Sarcoidosis.
Abstract Views: 3384
PDF: 2195
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

F. Carubbi
francescocarubbi@libero.it
Department of Medicine, ASL1 Avezzano Sulmona L’Aquila; Rheumatology Unit, Department of Biotechnological and Applied Clinical Science, University of L’Aquila, Italy.
A. Alunno
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
R. Gerli
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
R. Giacomelli
Rheumatology Unit, Department of Biotechnological and Applied Clinical Science, University of L’Aquila, Italy.

Salivary gland (SG) biopsy is a technique broadly applied for the diagnosis of primary Sjögren’s syndrome (pSS), lymphoma accompanying SS, sarcoidosis, amyloidosis, and IgG4-related disease The most peculiar feature of pSS on biopsy is focal lymphocytic sialadenitis. In the past, several histological scores have been reported in the literature to describe glandular involvement during pSS. However, the variability among centres in reporting glandular scores is one of the rationales behind the development of standardised consensus guidance. SGs as well as lacrimal glands are involved in up to 50% of patients with IgG4-related disease with 3 histopathological hallmarks such as dense lymphoplasmacytic infiltration, storiform fibrosis and obliterative phlebitis. SGs can be also affected by amyloidosis with MSG biopsy being more sensitive than that of rectal mucosa or subcutaneous fat. SG involvement is a rare manifestation during sarcoidosis, and the presence of non-caseating granulomas needs to be differentiated from granulomas of other etiology. This review article provides an overview of normal and pathological SGs in the context of rheumatic diseases, identifying key elements in the tissue as diagnostic and prognostic biomarkers, useful in the current clinical practice.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

Carubbi, F., Alunno, A., Gerli, R., & Giacomelli, R. (2018). Histopathology of salivary glands. Reumatismo, 70(3), 146–154. https://doi.org/10.4081/reumatismo.2018.1053

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Similar Articles

<< < 18 19 20 21 22 23 24 25 26 27 > >> 

You may also start an advanced similarity search for this article.