https://doi.org/10.4081/reumatismo.2018.1027

Antibodies to extractable nuclear antigens (ENAS) in systemic lupus erythematosus patients: correlations with clinical manifestations and disease activity

Vol. 70 No. 2 (2018)
Submitted: 3 June 2017
Accepted: 28 December 2017
Published: 6 July 2018
Extractable nuclear antigens (ENA), Systemic lupus erythematosus (SLE), Disease activity, SLEDAI, BILAG.
Abstract Views: 2515
PDF: 1258
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Authors

Y. Emad
yasseremad68@gmail.com
Rhumatology Department, Faculty of Medicine, Cairo University Cairo, Egypt.
T. Gheita
Rhumatology Department, Faculty of Medicine, Cairo University Cairo, Egypt.
H. Darweesh
Rhumatology Department, Faculty of Medicine, Cairo University Cairo, Egypt.
P. Klooster
Faculty of Behavioral, Management and Social sciences, Department Psychology, Health and Technology, University of Twente, Enschede, Netherlands.
R. Gamal
Rheumatology and rehabilitation Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
H. Fathi
Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
N. El-Shaarawy
Rheumatology and Rehabilitation Department, Suez Canal University, Ismailia, Egypt.
M. Gamil
Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
M. Hawass
Nephrology Department, Al-Shorta Hospital, Cairo, Egypt.
R.M. El-Refai
Rhumatology Department, Faculty of Medicine, Cairo University Cairo, Egypt.
H. Al-Hanafi
Clinical and chemical pathology department Faculty of Medicine, Cairo University, Cairo, Egypt.
S. Abd-Ellatif
Department of Rheumatology and Rehabilitation at Al-Azhar University, Cairo, Egypt.
A. Ismail
Dermatology department, Al-Azhar University, Cairo, Egypt.
J. Rasker
Faculty of Behavioral, Management and Social sciences, Department Psychology, Health and Technology, University of Twente, Enschede, Netherlands.
The aim was to explore possible correlations of antibodies to extractable nuclear antigens (ENA) with clinical manifestations and disease activity indices in systemic lupus erythematosus (SLE) patients. A total of 70 consecutive SLE patients (64 females) were included. Disease activity was assessed by SLE activity index (SLEDAI), and British Isles Lupus Assessment Group (BILAG). Anti-Ro/SSA correlated positively with, headache (r=0.24, p=0.04), blurring of vision (r=0.25, p=0.03) and SLEDAI (r=0.25, p=0.04) and negatively with C3 (r=–0.35, p=0.003). Anti-Ro/SSA correlated with anti La/SSB antibodies (r=0.69, p<0.001), but not with anti-DNA, anti-RNP and anti-Sm antibodies. Anti-La/SSB antibodies correlated with headache (r=0.26, p=0.03), SLEDAI (r=0.25, p=0.03) and negatively with C3 (r=–0.34, p=0.004). Anti-La/SSB did not correlate with anti-RNP or anti-Sm antibodies. Anti-Sm antibodies correlated with disease duration (r=0.34, p=0.003), 24 hours urinary proteins (r=0.31, p=0.008), SLEDAI (r=0.31, p=0.009), BILAG renal score (r=0.29, p=0.02) and negatively with age at onset (r=–0.27, p=0.02), WBCs (r=–0.29, p=0.014) and C4 (r=–0.25, p=0.049). In multivariate analyses, anti-Ro/SSA antibodies remained associated with headache, blurring of vision and C3 and anti-La/SSB antibodies remained associated with C3 and with headache. Anti-Sm antibodies were independently associated with disease duration and total SLEDAI scores, while anti-RNP antibodies remained significantly associated with BILAG mucocutaneous scores only. Antibodies to ENAs are associated with clinical aspects of SLE and may play a role in the assessment of disease activity. Insight into these ENAs may lead to new approaches to diagnostic testing, accurate evaluation of disease activity and lead to target approach for SLE.

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None to declare

How to Cite

Emad, Y., Gheita, T., Darweesh, H., Klooster, P., Gamal, R., Fathi, H., … Rasker, J. (2018). Antibodies to extractable nuclear antigens (ENAS) in systemic lupus erythematosus patients: correlations with clinical manifestations and disease activity. Reumatismo, 70(2), 85–91. https://doi.org/10.4081/reumatismo.2018.1027

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