https://doi.org/10.4081/reumatismo.2017.1007

Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series

Vol. 69 No. 4 (2017)
Submitted: 5 May 2017
Accepted: 4 August 2017
Published: 21 December 2017
Systemic lupus erythematosus, Demyelinating syndrome, Neuropsychiatric lupus, Magnetic resonance.
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Authors

E. Chessa
elis.chessa@gmail.com
Rheumatology Unit, University Clinic AOU of Cagliari, Italy.
M. Piga
Rheumatology Unit, University Clinic AOU of Cagliari, Italy.
A. Floris
Rheumatology Unit, University Clinic AOU of Cagliari, Italy.
A. Mathieu
Rheumatology Unit, University Clinic AOU of Cagliari, Italy.
A. Cauli
Rheumatology Unit, University Clinic AOU of Cagliari, Italy.
Demyelinating syndrome (DS) is a rare manifestation of systemic lupus erythematosus (SLE) (1%) with high clinical heterogeneity and potentially severe prognosis. It can represent a diagnostic and therapeutic challenge for clinicians. A recent study described 5 different patterns of demyelinating disease presentation, characterised by specific clinical, laboratory and brain and spine magnetic resonance imaging abnormalities: 1) neuromyelitis optica; 2) neuromyelitis optica spectrum disorders; 3) DS prevalently involving the brain; 4) DS prevalently involving the brainstem; 5) clinically isolated syndrome. In this review we briefly discuss typical characteristics of each DS presentation in SLE and we describe 5 illustrative clinical cases, one for each subset of DS, considering both diagnostic and therapeutic options.

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How to Cite

Chessa, E., Piga, M., Floris, A., Mathieu, A., & Cauli, A. (2017). Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series. Reumatismo, 69(4), 175–183. https://doi.org/10.4081/reumatismo.2017.1007

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