Disease activity assessment in large vessel vasculitis

  • L. Magnani Struttura Complessa di Reumatologia, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
  • A. Versari Medicina Nucleare, ASMN, Reggio Emilia, Italy.
  • D. Salvo Medicina Nucleare, ASMN, Reggio Emilia, Italy.
  • M. Casali Medicina Nucleare, ASMN, Reggio Emilia, Italy.
  • G. Germanò Struttura Complessa di Reumatologia, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
  • R. Meliconi Modulo di Reumatologia, Istituto Ortopedico Rizzoli (IOR) e Università di Bologna, Bologna, Italy.
  • L. Pulsatelli Laboratorio di Immunoreumatologia e genetica, IOR, Bologna, Italy.
  • D. Formisano Epidemiologia e statistica, ASMN, Reggio Emilia, Italy.
  • G. Bajocchi Struttura Complessa di Reumatologia, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
  • N. Pipitone Struttura Complessa di Reumatologia, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
  • L. Boiardi Struttura Complessa di Reumatologia, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
  • C. Salvarani | Salvarani.carlo@asmn.re.it Struttura Complessa di Reumatologia, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.

Abstract

Disease activity assessment in large vessel vasculitis (LVV) is often challenging for physicians. In this study, we compared the assessment of disease activity based on inflammatory markers, clinical indices (Indian Takayasu Activity Score [ITAS] and the Kerr/National Institute of Health indices [Kerr/NIH]), and 18F-Fluorodesossiglucose (FGD) vascular uptake at positron emission tomography (Pet). We found that Pet results did not statistically correlate with the clinical indices ITAS and Kerr/NIH, because FDG uptake was increased (grade>2 on a 0-3 scale in at least one evaluated vascular segment) in many patients with inactive disease according to clinical and laboratory parameters (i.e., negative ITAS and Kerr/NIH indices as well as normal erythrocyte sedimentation rate (ESR) and C-reactive protein (PCR)). Similarly, interleukin- 6 and its soluble receptor did not statistically correlate with disease activity. In contrast, clinical indices showed a significant correlation between each other and with inflammatory markers (VES and PCR). These data suggest that while clinical indices and inflammatory markers may be useful to assess disease activity, Pet may be more sensitive.

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Keywords:
Takayasu arteritis, large vessel vasculitis, GCA, Pet, interleukine 6, disease assessment
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How to Cite
Magnani, L., Versari, A., Salvo, D., Casali, M., Germanò, G., Meliconi, R., Pulsatelli, L., Formisano, D., Bajocchi, G., Pipitone, N., Boiardi, L., & Salvarani, C. (1). Disease activity assessment in large vessel vasculitis. Reumatismo, 63(2), 86-90. https://doi.org/10.4081/reumatismo.2011.86