Jaccoud’s arthropathy, an unusual manifestation of idiopathic retroperitoneal fibrosis: rapid improvement of symptoms after tocilizumab treatment

  • M. Benucci | maurizio.benucci@uslcentro.toscana.it Rheumatology Unit, San Giovanni di Dio Hospital, Florence, Italy.
  • A. Damiani Rheumatology Unit, San Giovanni di Dio Hospital, Florence, Italy.
  • F. Li Gobbi Rheumatology Unit, San Giovanni di Dio Hospital, Florence, Italy.
  • V. Grossi Immunology and Allergology Laboratory, San Giovanni di Dio Hospital, Florence, Italy.
  • M. Infantino Immunology and Allergology Laboratory, San Giovanni di Dio Hospital, Florence, Italy.
  • A. Arena Nuclear Medicine, New Hospital, Prato, Italy.
  • M. Manfredi Immunology and Allergology Laboratory, San Giovanni di Dio Hospital, Florence, Italy.

Abstract

Jaccoud’s arthropathy (JA) is a chronic, non erosive, rheumatoid-like deformity associated with rheumatic fever (RF) and systemic lupus erythematosus and with other diseases such as psoriatic arthritis, connective tissue diseases, hypocomplementemic urticarial vasculitis, infections, sarcoidosis and neoplasia. We described a case of JA in a patient with cutaneous psoriasis but with a particular disease evolution associated with idiopathic retropritoneal fibrosis (IRF), evaluated with computed tomography, magnetic resonance and 18F-FDG PET/ CT. The patient, following failure with steroids, methotrexate and etanercept, was treated with tocilizumab (8 mg/kg) once every 4 weeks for 6 months. A rapid improvement of symptoms and disappearance of 18F-FDG uptake was shown. We describe a review of literature of rheumatic manifestations of IRF and the possible role of interleukin-6 in the pathway of JA and IRF.

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Published
2017-08-03
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Section
Case Reports
Keywords:
Jaccoud’s arthropathy, Idiopathic Retroperitoneal fibrosis, Tocilizumab.
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How to Cite
Benucci, M., Damiani, A., Li Gobbi, F., Grossi, V., Infantino, M., Arena, A., & Manfredi, M. (2017). Jaccoud’s arthropathy, an unusual manifestation of idiopathic retroperitoneal fibrosis: rapid improvement of symptoms after tocilizumab treatment. Reumatismo, 69(2), 88-91. https://doi.org/10.4081/reumatismo.2017.968

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