Predictive value of isolated DLCO reduction in systemic sclerosis patients without cardio-pulmonary involvement at baseline

  • M. Colaci | michelecolaci@virgilio.it Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, University Hospital of Modena, Italy.
  • D. Giuggioli Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, University Hospital of Modena, Italy.
  • M. Sebastiani Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, University Hospital of Modena, Italy.
  • A. Manfredi Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, University Hospital of Modena, Italy.
  • F. Lumetti Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, University Hospital of Modena, Italy.
  • F. Luppi Respiratory Disease Unit, University of Modena and Reggio Emilia, Medical School, University Hospital of Modena, Italy.
  • S. Cerri Respiratory Disease Unit, University of Modena and Reggio Emilia, Medical School, University Hospital of Modena, Italy.
  • C. Ferri Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, University Hospital of Modena, Italy.

Abstract

Impaired diffusing capacity of the lung for carbon monoxide (DLCO) was frequently observed in systemic sclerosis (SSc) patients, generally related to the presence of interstitial lung disease (ILD) and/or pulmonary arterial hypertension (PAH). However, in clinical practice abnormally low DLCO values may be found also in the absence of these SSc complications. The objective was to investigate the prospective clinical relevance of isolated DLCO reduction at baseline in SSc patients. Ninety-seven SSc female patients (age at the diagnosis: 51.3±14.5 years; disease duration: 10.4±6.6 years; limited/diffuse skin subsets: 92/5), without any clinical, radiological (high resolution computed tomography), and echocardiographic manifestations of ILD or PAH at baseline, nor other lung or heart diseases able to affect DLCO, were recruited at our Rheumatology Centre. Patients with DLCO <55% (15 patients; group A) were compared with those with normal DLCO (82 patients; group B), at baseline and at the end of follow-up. At baseline, patients of group A showed significantly higher percentage of anticentromere autoantibodies compared to group B (13/15, 86.6% vs 48/82, 58.5%; p=0.044). More interestingly, at the end of long-lasting clinical follow-up (11.6±6.7 years), pre-capillary PAH (right heart catheterization) solely developed in some patients of group A (3/15, 20% vs 0/82; p=0.003). In SSc patients, the presence at baseline of isolated, marked DLCO reduction (<55% of predicted) and serum anticentromere autoantibodies might characterize a peculiar SSc subset that may precede the development of PAH. Therefore, careful clinical follow-up of patients with isolated moderate-severe DLCO reduction should be mandatory.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2016-05-23
Info
Issue
Section
Articles
Keywords:
Scleroderma, systemic sclerosis, DLCO, pulmonary arterial hypertension, lung fibrosis.
Statistics
  • Abstract views: 1189

  • PDF: 725
How to Cite
Colaci, M., Giuggioli, D., Sebastiani, M., Manfredi, A., Lumetti, F., Luppi, F., Cerri, S., & Ferri, C. (2016). Predictive value of isolated DLCO reduction in systemic sclerosis patients without cardio-pulmonary involvement at baseline. Reumatismo, 67(4), 149-155. https://doi.org/10.4081/reumatismo.2015.837