Inflammatory optic neuropathy in Behçet’s disease

  • M. S. Khanfir | smitimonia@yahoo.fr Department of Internal Medicine, La Rabta University Hospital, Tunis; Faculty of Medicine of Tunis, University of Tunis-El Manar, Tunisia.
  • N. Belfeki Department of Internal Medicine, La Rabta University Hospital, Tunis; Faculty of Medicine of Tunis, University of Tunis-El Manar, Tunisia.
  • F. Said Department of Internal Medicine, La Rabta University Hospital, Tunis; Faculty of Medicine of Tunis, University of Tunis-El Manar, Tunisia.
  • T. Ben Salem Department of Internal Medicine, La Rabta University Hospital, Tunis; Faculty of Medicine of Tunis, University of Tunis-El Manar, Tunisia.
  • I. Ben Ghorbel Department of Internal Medicine, La Rabta University Hospital, Tunis; Faculty of Medicine of Tunis, University of Tunis-El Manar, Tunisia.
  • M. Lamloum Department of Internal Medicine, La Rabta University Hospital, Tunis; Faculty of Medicine of Tunis, University of Tunis-El Manar, Tunisia.
  • A. Hamzaoui Department of Internal Medicine, La Rabta University Hospital, Tunis; Faculty of Medicine of Tunis, University of Tunis-El Manar, Tunisia.
  • M. H. Houman Department of Internal Medicine, La Rabta University Hospital, Tunis; Faculty of Medicine of Tunis, University of Tunis-El Manar, Tunisia.

Abstract

Inflammatory optic neuropathy (ON) is a rare event in Behçet’s disease (BD). We report herein a series of ten BD Tunisian patients with ON and describe its clinical features among them. A retrospective review of BD patients (International Study Group for BD criteria) was performed. The patients were divided into two groups: those presenting an inflammatory ON, and those none. The diagnosis of inflammatory ON was based on the clinical examination, visual field and visual evoked potentials. We analyzed the characteristics of the two groups. Ten patients (2.3%) presented an inflammatory ON among our 440 patients. Inflammatory ON was inaugural in 8 cases. Clinical manifestations were as follows: blurred vision (7 cases) and periorbital pain (3 cases). In two cases, the patients did not complain from ophthalmological symptoms. The fundus revealed a papilledema (2 cases), papillary pallor (4 cases), and was normal in 5 cases. Visual field realized in only three patients showed a scotoma in all cases. Visual evoked potentials revealed increased latency in all cases. All patients received corticosteroids associated to an immunosuppressive agent. The comparative study between the two groups revealed that inflammatory ON was significantly more associated to neurological involvement (p<0.0001) and that the disease was more severe in the ON group (p<0.0001). Inflammatory ON in BD is rare and may occur at an early stage of the clinical course of the disease. Its prevalence is certainly underestimated. A systematic visual evoked potential may be interesting as a screening tool.

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Author Biography

M. S. Khanfir, Department of Internal Medicine, La Rabta University Hospital, Tunis; Faculty of Medicine of Tunis, University of Tunis-El Manar
Department of Internal Medicine
Published
2016-05-23
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Keywords:
Optic neuropathy, Behçet’s disease, inflammation.
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How to Cite
Khanfir, M. S., Belfeki, N., Said, F., Ben Salem, T., Ben Ghorbel, I., Lamloum, M., Hamzaoui, A., & Houman, M. H. (2016). Inflammatory optic neuropathy in Behçet’s disease. Reumatismo, 67(4), 156-160. https://doi.org/10.4081/reumatismo.2015.835