Efficacy of gluten-free diet in patients with rheumatoid arthritis

Abstract

Recent research has increasingly shown that depending on the foods we eat, gut flora may be affected by an inflammatory or anti-inflammatory response, thus playing an important role in inflammatory autoimmune diseases, such as rheumatoid arthritis or gastroenterological disorders. Gluten seems to be a glycoprotein with a clinically relevant inflammatory effect. Several observational studies and anecdotal cases reported a correlation between gluten and various diseases, including autoimmune diseases, such as rheumatoid arthritis. This study aimed to evaluate whether gluten-free diet could be effective in controlling inflammation and ongoing rheumatoid arthritis symptoms. We report 4 cases of patients with long-standing rheumatoid arthritis with no response to several conventional and biotechnological drugs, treated with a gluten-free diet concurrently with the drug therapy. Our patients presented different degrees of response to the diet, in terms of disease remission and improvement of symptoms. Our cases confirm that a gluten-free diet may improve symptoms of rheumatoid arthritis, even in patients resistant to conventional drug therapies.

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Published
2021-01-18
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Articles
Keywords:
Gluten-free diet, rheumatoid arthritis, celiac disease, non-celiac gluten sensitivity.
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How to Cite
Bruzzese, V., Scolieri, P., & Pepe, J. (2021). Efficacy of gluten-free diet in patients with rheumatoid arthritis. Reumatismo, 72(4), 213-217. https://doi.org/10.4081/reumatismo.2020.1296