https://doi.org/10.4081/reumatismo.2017.1032

The clinical spectrum of primary Sjögren’s syndrome: beyond exocrine glands

Vol. 69 No. 3 (2017)
Submitted: 20 June 2017
Accepted: 28 July 2017
Published: 21 September 2017
Sjögren’s syndrome, Extra-glandular manifestations, Cardiovascular risk.
Abstract Views: 2974
PDF: 1518
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Authors

M.C. Leone
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
A. Alunno
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
G. Cafaro
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
V. Valentini
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
E. Marcucci
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
E. Bartoloni
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
R. Gerli
roberto.gerli@unipg.it
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Although primary Sjögren’s syndrome (pSS) is a mild indolent chronic disease mainly characterized by mucosal dryness in the majority of cases, a consistent subgroup of patients display extra-glandular manifestations. Virtually any organs and systems can be affected, leading to a more serious disease prognosis. Therefore, the prompt identification of patients at higher risk of extra-glandular manifestations is necessary to start a thorough follow up and an aggressive treatment. The aim of this review article is to provide an overview of epidemiological, clinical and serological features of extra-glandular manifestations in pSS as well as current knowledge about putative biomarkers useful in clinical practice.

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How to Cite

Leone, M., Alunno, A., Cafaro, G., Valentini, V., Marcucci, E., Bartoloni, E., & Gerli, R. (2017). The clinical spectrum of primary Sjögren’s syndrome: beyond exocrine glands. Reumatismo, 69(3), 93–100. https://doi.org/10.4081/reumatismo.2017.1032

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